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Protein

Acetate kinase

Gene

ackA

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei148Proton donor/acceptorUniRule annotation1
Sitei180Transition state stabilizerUniRule annotation1
Sitei241Transition state stabilizerUniRule annotation1
Metal bindingi384MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 212ATPUniRule annotation5
Nucleotide bindingi283 – 285ATPUniRule annotation3
Nucleotide bindingi331 – 335ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOL335541:G1G78-784-MONOMER
UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Swol_0768
OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Taxonomic identifieri335541 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
Proteomesi
  • UP000001968 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022801 – 397Acetate kinaseAdd BLAST397

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi335541.Swol_0768

Structurei

3D structure databases

ProteinModelPortaliQ0AYW5
SMRiQ0AYW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiFMMQKEN
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0AYW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLVVNAGS SSIKYQVVDM TDESVLAVGL VDRVGIPGTT LDHSPLGKDK
60 70 80 90 100
VTIKKDLPDH TAGMELVLQV LVNEEYGCIK SMDEIGAVGH RVVHGGEGFA
110 120 130 140 150
ESVVIDDEVK RVIKECFEIA PLHNPPNMMG IEACQRLMPN VKHVAVFDTA
160 170 180 190 200
FHQTMGPANF MYALPYDVYE KFRVRRYGFH GTSHFYVAHR AAEMLGKPYE
210 220 230 240 250
ECKIITLHLG NGASMAAIKD GKVIDTSMGF TPLEGLVMGT RSGDIDPAIV
260 270 280 290 300
FFLMDKLGMN SSEANNYFNK KSGMLGLSGV SNDLRDILEA AGSGNERAKI
310 320 330 340 350
ALDVYYNKVK GYIGNYIAKL NGVDCLVFTA GVGENAIDIR ENVCANLDYL
360 370 380 390
GIKMDVEKNK VRGKEVDVAT ADSKVRIFLI PTNEELVIAR DTFNLAK
Length:397
Mass (Da):43,420
Last modified:October 17, 2006 - v1
Checksum:i3C79B256CD3096B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000448 Genomic DNA Translation: ABI68089.1
RefSeqiWP_011640194.1, NC_008346.1

Genome annotation databases

EnsemblBacteriaiABI68089; ABI68089; Swol_0768
KEGGiswo:Swol_0768

Similar proteinsi

Entry informationi

Entry nameiACKA_SYNWW
AccessioniPrimary (citable) accession number: Q0AYW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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