UniProtKB - Q0AVM4 (BCD1_SYNWW)
Protein
Butyryl-CoA dehydrogenase Swol_1933
Gene
Swol_1933
Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Functioni
Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Catalyzes the oxidation of butanoyl-CoA to crotonyl-CoA. Probably passes the electrons released by this reaction on to electron-transfer flavoproteins (EtfAB) to finally generate hydrogen and/or formate.1 Publication1 Publication
Catalytic activityi
- butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]1 PublicationEC:1.3.8.11 Publication
- a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]1 PublicationEC:1.3.8.11 Publication
Cofactori
FADBy similarity1 Publication
: butanoate metabolism Pathwayi
This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.2 PublicationsView all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 451 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
- flavin adenine dinucleotide binding Source: InterPro
GO - Biological processi
- butyrate metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BioCyci | SWOL335541:G1G78-2011-MONOMER |
UniPathwayi | UPA00863 |
Names & Taxonomyi
Protein namesi | Recommended name: Butyryl-CoA dehydrogenase Swol_19332 Publications (EC:1.3.8.11 Publication)Short name: BCD2 Publications |
Gene namesi | Ordered Locus Names:Swol_1933Imported |
Organismi | Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) |
Taxonomic identifieri | 335541 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophomonas › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm 1 Publication
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000442211 | 1 – 610 | Butyryl-CoA dehydrogenase Swol_1933Add BLAST | 610 |
Expressioni
Inductioni
Family & Domainsi
Sequence similaritiesi
Belongs to the acyl-CoA dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1960, Bacteria |
HOGENOMi | CLU_018204_12_2_9 |
OrthoDBi | 357522at2 |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR025878, Acyl-CoA_dh-like_C_dom IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF12806, Acyl-CoA_dh_C, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0AVM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHENYLYQM RDIKFAVKEW LDMNKLLSCD AYKDYYGIDD IDAFLDVNFK
60 70 80 90 100
VCRDVLCPAN KEADDPGCKF VGGDTQAVIT PEVFKNAYNT VCEAGLGPQF
110 120 130 140 150
SDRSAEGRMP LVWEAPILEM QSGASPSIVM FWCLTAGACT VIQHNASEEL
160 170 180 190 200
KERFLPKMYS GEWGGTMGLT EPGAGSEVGA VATKCFPTDT PGLYKIKGQK
210 220 230 240 250
CFITSGDHDL ASNIIHLVLA KTPDAKPGTS GINCLIVPKF WVNEDGTQGA
260 270 280 290 300
WNDVTSTGIE HKMGIHGSST LSLSFGENDN CYGWMIGDGP VDGRGKGMAQ
310 320 330 340 350
MFQMMNEERL NTGTFAQGCI GSAYYAALDY CKMRVQSPKF TDPKGPSVRI
360 370 380 390 400
IEHEDVRRML LFQKSIMEAC RALLYTTYFY QDLSHDAADP AEREYYDDMT
410 420 430 440 450
MIQIPLCKAY VSDMAWISTE QAIQCLGGYG FIEEYAPAEL ARDCKIYSLW
460 470 480 490 500
EGTNFIQAQD FNNRKTTMKK GEPMKKWVAQ IADFLATKKD PAFADEFAMM
510 520 530 540 550
DDAFSAYNEI LSTKEAWRAS NPQLVQLFAT RMLHAASMMI CGKLMLDQAL
560 570 580 590 600
LAAKKLAELG EDHFDAMFYK GKIATARFYV MNVVPGVFGT LKAMKVADTS
610
AIDMPEEAFM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000448 Genomic DNA Translation: ABI69230.1 |
RefSeqi | WP_011641323.1, NC_008346.1 |
Genome annotation databases
EnsemblBacteriai | ABI69230; ABI69230; Swol_1933 |
KEGGi | swo:Swol_1933 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000448 Genomic DNA Translation: ABI69230.1 |
RefSeqi | WP_011641323.1, NC_008346.1 |
3D structure databases
SMRi | Q0AVM4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 335541.Swol_1933 |
Genome annotation databases
EnsemblBacteriai | ABI69230; ABI69230; Swol_1933 |
KEGGi | swo:Swol_1933 |
Phylogenomic databases
eggNOGi | COG1960, Bacteria |
HOGENOMi | CLU_018204_12_2_9 |
OrthoDBi | 357522at2 |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
BioCyci | SWOL335541:G1G78-2011-MONOMER |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR025878, Acyl-CoA_dh-like_C_dom IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF12806, Acyl-CoA_dh_C, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCD1_SYNWW | |
Accessioni | Q0AVM4Primary (citable) accession number: Q0AVM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2017 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families