UniProtKB - Q0AVA8 (BCD2_SYNWW)
Protein
Butyryl-CoA dehydrogenase Swol_2052
Gene
Swol_2052
Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Functioni
Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Catalyzes the oxidation of butanoyl-CoA to crotonyl-CoA. Probably passes the electrons released by this reaction on to electron-transfer flavoproteins (EtfAB) to finally generate hydrogen and/or formate.1 Publication1 Publication
Catalytic activityi
- butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]1 PublicationEC:1.3.8.11 Publication
- a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]1 PublicationEC:1.3.8.11 Publication
Cofactori
FADBy similarity1 Publication
: butanoate metabolism Pathwayi
This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.2 PublicationsView all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 451 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- butyrate metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BioCyci | SWOL335541:G1G78-2140-MONOMER |
UniPathwayi | UPA00863 |
Names & Taxonomyi
Protein namesi | Recommended name: Butyryl-CoA dehydrogenase Swol_20522 Publications (EC:1.3.8.11 Publication)Short name: BCD2 Publications |
Gene namesi | Ordered Locus Names:Swol_2052Imported |
Organismi | Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) |
Taxonomic identifieri | 335541 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophomonas › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm 1 Publication
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000442212 | 1 – 610 | Butyryl-CoA dehydrogenase Swol_2052Add BLAST | 610 |
Expressioni
Inductioni
Family & Domainsi
Sequence similaritiesi
Belongs to the acyl-CoA dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1960, Bacteria |
HOGENOMi | CLU_018204_12_2_9 |
OMAi | NTCEMTF |
OrthoDBi | 433393at2 |
Family and domain databases
InterProi | View protein in InterPro IPR025878, Acyl-CoA_dh-like_C_dom IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF12806, Acyl-CoA_dh_C, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0AVA8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPHNNYLYQT RDIKFQIKEW LDINKILSLD AYKDYYGADD FDAICDVNFK
60 70 80 90 100
ICRDVICPAN KESDEIGMKH VGGNEKAVIS PDVFKTVYNT VIEAGMGPQF
110 120 130 140 150
GDRQVEGRMP LYWYAPILEM QTGASPAMVM LWCLTQGATT VLQYNLSKEL
160 170 180 190 200
QERFLPKMYS GEWGGSMCLT EPGAGSEVGA VSTKCFPTDT PGLWKVKGQK
210 220 230 240 250
CFITTGDWDG VDNIIHLVLA KDPDAKPGTA GISCLVVPKF WVNEDGSMGA
260 270 280 290 300
WNDVTTTGIE HKLGIHGSAT CSLAFGENDN CYGWMIGDGP VDGRGQGMAQ
310 320 330 340 350
MFQMMNEERI NTGIFSLGAF GAAYYAALEY SKARVQSKKS TDPKGPSVRI
360 370 380 390 400
IEHEDVRRML LLQKSVMEAC RALLYSSYYY IDMSKEAATE EEREYAEDMF
410 420 430 440 450
MIQNPLCKAY VSDMAWVMCA EAIQVHGGYG FMEEYAPASL ARDCKIYTLW
460 470 480 490 500
EGTNFIQSQD FTGRKFTMKK GEPFKKWLAE IGDFIANKKT PEFAAEFAMM
510 520 530 540 550
EKAFAAFNSI IDMNAAWTTT NKQLKQLFAT RIMHAAARVI CGKLMLDQGL
560 570 580 590 600
LAAGKLAELG DSHFDANFYK GKLASVKFYV MNVVPEIFGT EEAMKAADTS
610
AIDCPEEAIM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000448 Genomic DNA Translation: ABI69346.1 |
RefSeqi | WP_011641438.1, NC_008346.1 |
Genome annotation databases
EnsemblBacteriai | ABI69346; ABI69346; Swol_2052 |
KEGGi | swo:Swol_2052 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000448 Genomic DNA Translation: ABI69346.1 |
RefSeqi | WP_011641438.1, NC_008346.1 |
3D structure databases
SMRi | Q0AVA8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 335541.Swol_2052 |
Genome annotation databases
EnsemblBacteriai | ABI69346; ABI69346; Swol_2052 |
KEGGi | swo:Swol_2052 |
Phylogenomic databases
eggNOGi | COG1960, Bacteria |
HOGENOMi | CLU_018204_12_2_9 |
OMAi | NTCEMTF |
OrthoDBi | 433393at2 |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
BioCyci | SWOL335541:G1G78-2140-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR025878, Acyl-CoA_dh-like_C_dom IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF12806, Acyl-CoA_dh_C, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCD2_SYNWW | |
Accessioni | Q0AVA8Primary (citable) accession number: Q0AVA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2017 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families