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Entry version 62 (16 Oct 2019)
Sequence version 1 (17 Oct 2006)
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Protein

Cortactin-binding protein 2

Gene

CTTNBP2

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTTNBP2
Synonyms:CORTBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002604141 – 1641Cortactin-binding protein 2Add BLAST1641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei491Asymmetric dimethylarginineBy similarity1
Modified residuei1512PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q09YI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q09YI1 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTTN/cortactin SH3 domain.

Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000010942

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09YI1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati702 – 732ANK 1Add BLAST31
Repeati736 – 765ANK 2Add BLAST30
Repeati769 – 798ANK 3Add BLAST30
Repeati802 – 831ANK 4Add BLAST30
Repeati835 – 864ANK 5Add BLAST30
Repeati903 – 933ANK 6Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 276Sequence analysisAdd BLAST158

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158293

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSCRPCD

Database of Orthologous Groups

More...
OrthoDBi
264951at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF09727 CortBP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q09YI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDGASCEP DFSRAPEDAA GAPAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGASDKEK
110 120 130 140 150
KPVCTNPLSI LEAVMAHCRK MQERMSTQLA AAESRQKKLE MEKLQLQALE
160 170 180 190 200
QEHKKLAARL EEERGKNKHV VLMLVKECKQ LSGKVLEEAQ KLEEVMAKLE
210 220 230 240 250
EEKKKTSALE EELATEKRRS AEMEAQMEKQ LSEFDTEREQ LRAKLHREEA
260 270 280 290 300
HTTDLKEEID KMKKMIEQLK RGNDSKPSLS LPRKTKDRRL VSISVATEGP
310 320 330 340 350
MTRSVACQTD LVTETAEPLK KLPLTVPVKP AAGSPLVSAS AKGNACASAA
360 370 380 390 400
SVRPGIERQV SHGDLIGSSL PTVPPPSTDR IEENGPSTGS TPDLTSSPTA
410 420 430 440 450
LPSTVSPASG HTPTPPPHSL HSPCANAPLH PGLNPRIQAA RFRFQGSNAN
460 470 480 490 500
DPDQNGNTTQ SPPSRDVSPT SRDTLVAKQL ARNTVTQALS RFTSPPAGAP
510 520 530 540 550
PRPGAPPTGD VGTYPPVGRT SLKTPGGARV DRGNPPPIPP KKPGLSQTPS
560 570 580 590 600
PPHPQLKVIM DSSRASSTGI KADNKTVASS PSSLPQGNRV INEENLSKSS
610 620 630 640 650
SPQLPPKPSI DLTVAPAGCA VSALATSQVG AWPAETPGLN QPACSESSLV
660 670 680 690 700
IPTTTAFRSS INPVSASSRR AGASDSLLVT ASGWSPSLTP LLMSGGPAPL
710 720 730 740 750
AGRPTLLQQA AAQGNVTLLS MLLNEEGLDI NYSCEDGHSA LYSAAKNGHT
760 770 780 790 800
DCVRLLLNAE AQVNAADKNG FTPLCAAAAQ GHFKCVELLI AYDANINHAA
810 820 830 840 850
DGGQTPLYLA CKNGNKECIK LLLEAGTDRS VKTRDGWTPI HAAVDTGNVD
860 870 880 890 900
SLKLLMYHGA PAHGNKLQEE PGLAIFDLDQ EEHHEGTSKP VVPADLINHA
910 920 930 940 950
DSEGWTAAHI AASKGFKNCL EVLCRHGGLE PERRDKCNRT AHDVATDDCK
960 970 980 990 1000
HLLENLNALK IPLRISVGEI EPGNYGADDF ECENTICALN IRKQTSWDDF
1010 1020 1030 1040 1050
SKAVSQALTN HFQAISSDGW WSLEDMTFNS TTDSSIGLSA SSVRSITLGS
1060 1070 1080 1090 1100
VPWSAGQSFT QSPWDFMRTN KAEQVTVLLS GPQEGCLSSV TYASMIPLQM
1110 1120 1130 1140 1150
LQNYLRLVEQ YHNVIFHGPE GSLQDYIAHQ LALCLKHRQM AAGFPCEIVR
1160 1170 1180 1190 1200
AEVDADFSKE QLVDLFISSA CLIPVKQSPA NKKIIIILEN LEKSSLSELL
1210 1220 1230 1240 1250
GDFLGPLENH STESPCTFQK GNGMSECYYF HENCFLMGTI AKACLQGSDL
1260 1270 1280 1290 1300
LVQQHFRWVQ LRWDSEPMQG LLQRFLRRKV VNKFRGQVPS PCDPVCKTVD
1310 1320 1330 1340 1350
WALAVWRQLN SCLARLGTPE ALLGPKYFLS CPVIPGHAQA TVKWMSKLWN
1360 1370 1380 1390 1400
AVIAPRVQEA ILSRASVKRQ PGLGQTTKNP SQGQQAVVRA ALSILLNKAV
1410 1420 1430 1440 1450
LHGCPLQRAE LDQHTADFKG GSFPLSIVSS YSSCSKKRES GAWRKVSTSP
1460 1470 1480 1490 1500
RKKSGRFSSP TWNKPDLSEE GIKSNTILQL NCNRNASLSN QKSLENDLSL
1510 1520 1530 1540 1550
TLNLDQRLSL GSDDEADLVK ELQSMCSSKS ESDISKIADS RDDLRRFDSS
1560 1570 1580 1590 1600
GNNPVFSATV NNPRMPVSQK EVSPLSSHQM TERSNSKSKT ESGVSRVKSF
1610 1620 1630 1640
LPVPRSKVTQ CSQNTKRSSS SSNTRQIEIN NNSRDLEPTQ K
Length:1,641
Mass (Da):178,220
Last modified:October 17, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C1A5C3CE6F216C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W5PKG7W5PKG7_SHEEP
Cortactin-binding protein 2
CTTNBP2
1,546Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DP000179 Genomic DNA Translation: ABI75299.1

NCBI Reference Sequences

More...
RefSeqi
NP_001182240.1, NM_001195311.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOART00000011100; ENSOARP00000010942; ENSOARG00000010183

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100126575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
oas:100126575

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000179 Genomic DNA Translation: ABI75299.1
RefSeqiNP_001182240.1, NM_001195311.1

3D structure databases

SMRiQ09YI1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000010942

Proteomic databases

PRIDEiQ09YI1

Genome annotation databases

EnsembliENSOART00000011100; ENSOARP00000010942; ENSOARG00000010183
GeneIDi100126575
KEGGioas:100126575

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83992

Phylogenomic databases

GeneTreeiENSGT00940000158293
OMAiSSCRPCD
OrthoDBi264951at2759

Gene expression databases

ExpressionAtlasiQ09YI1 baseline

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF09727 CortBP2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTTB2_SHEEP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09YI1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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