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Entry version 133 (02 Jun 2021)
Sequence version 1 (17 Oct 2006)
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Protein

Chromodomain-helicase-DNA-binding protein 8

Gene

Chd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

UniRule annotation2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi838 – 845ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3769402, Deactivation of the beta-catenin transactivating complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 8UniRule annotation (EC:3.6.4.12UniRule annotation)
Short name:
CHD-8UniRule annotation
Alternative name(s):
ATP-dependent helicase CHD8UniRule annotation
Axis duplication inhibitor
Short name:
Duplin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chd8UniRule annotation
Synonyms:Kiaa1564
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915022, Chd8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death during early embryogenesis due to widespread apoptosis. Embryos manifest growth retardation from 5.5 dpc and developmental arrest accompanied by massive apoptosis at 7.5 dpc. They develop into an egg cylinder but do not form a primitive streak or mesoderm. Mice lacking both Tp53 and Chd8 ameliorate this developmental arrest.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003673101 – 2582Chromodomain-helicase-DNA-binding protein 8Add BLAST2582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei434PhosphoserineBy similarity1
Modified residuei555PhosphoserineCombined sources1
Modified residuei564PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)UniRule annotation
Modified residuei1422PhosphoserineCombined sources1
Modified residuei1426PhosphoserineCombined sources1
Modified residuei1978PhosphoserineBy similarity1
Modified residuei1980PhosphoserineBy similarity1
Modified residuei1995PhosphothreonineBy similarity1
Modified residuei1997PhosphoserineBy similarity1
Modified residuei1999PhosphoserineCombined sources1
Modified residuei2010PhosphoserineBy similarity1
Cross-linki2027Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2040PhosphoserineCombined sources1
Modified residuei2070PhosphoserineBy similarity1
Modified residuei2072PhosphoserineBy similarity1
Modified residuei2184PhosphoserineBy similarity1
Modified residuei2202PhosphoserineCombined sources1
Modified residuei2204PhosphoserineCombined sources1
Modified residuei2206PhosphothreonineCombined sources1
Modified residuei2213PhosphoserineCombined sources1
Modified residuei2217PhosphothreonineCombined sources1
Modified residuei2225PhosphoserineBy similarity1
Cross-linki2258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2520PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.UniRule annotation

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q09XV5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q09XV5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q09XV5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09XV5

PeptideAtlas

More...
PeptideAtlasi
Q09XV5

PRoteomics IDEntifications database

More...
PRIDEi
Q09XV5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281607 [Q09XV5-1]
281608 [Q09XV5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q09XV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q09XV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed predominantly from early- to mid-stage mouse embryogenesis. Detected throughout embryos from 7.5 to 9.5 dpc but localizes predominantly in the brain, faces, branchial arches, limb buds, and tail buds of embryos at 10.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053754, Expressed in embryonic post-anal tail and 324 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q09XV5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q09XV5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1 and PIAS3.

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

Interacts with CHD7.

Interacts with FAM124B (By similarity).

Interacts with p53/TP53 and histone H1 (PubMed:19151705).

Interacts with CTCF (PubMed:16949368).

UniRule annotation2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212432, 17 interactors

Protein interaction database and analysis system

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IntActi
Q09XV5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000087184

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q09XV5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09XV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini644 – 711Chromo 1UniRule annotationAdd BLAST68
Domaini726 – 792Chromo 2UniRule annotationAdd BLAST67
Domaini825 – 999Helicase ATP-bindingUniRule annotationAdd BLAST175
Domaini1139 – 1290Helicase C-terminalUniRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 111DisorderedSequence analysisAdd BLAST90
Regioni136 – 155DisorderedSequence analysisAdd BLAST20
Regioni253 – 283DisorderedSequence analysisAdd BLAST31
Regioni349 – 377DisorderedSequence analysisAdd BLAST29
Regioni475 – 585DisorderedSequence analysisAdd BLAST111
Regioni598 – 617DisorderedSequence analysisAdd BLAST20
Regioni1694 – 1715DisorderedSequence analysisAdd BLAST22
Regioni1791 – 2304Interaction with FAM124BUniRule annotationAdd BLAST514
Regioni1990 – 2019DisorderedSequence analysisAdd BLAST30
Regioni2045 – 2120DisorderedSequence analysisAdd BLAST76
Regioni2187 – 2233DisorderedSequence analysisAdd BLAST47
Regioni2486 – 2582DisorderedSequence analysisAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi950 – 953DEAH boxUniRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 58Polar residuesSequence analysisAdd BLAST16
Compositional biasi89 – 111Polar residuesSequence analysisAdd BLAST23
Compositional biasi357 – 373Pro residuesSequence analysisAdd BLAST17
Compositional biasi490 – 523Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi562 – 585Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1694 – 1712Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2076 – 2095Polar residuesSequence analysisAdd BLAST20
Compositional biasi2096 – 2118Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi2492 – 2512Basic residuesSequence analysisAdd BLAST21
Compositional biasi2516 – 2532Polar residuesSequence analysisAdd BLAST17
Compositional biasi2537 – 2554Acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0384, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153649

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q09XV5

Identification of Orthologs from Complete Genome Data

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OMAi
QANAWKK

Database of Orthologous Groups

More...
OrthoDBi
7181at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.130, 1 hit
3.40.50.10810, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03071, CHD8, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006576, BRK_domain
IPR037259, BRK_sf
IPR034724, CHD8
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07533, BRK, 1 hit
PF00385, Chromo, 2 hits
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592, BRK, 2 hits
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF160481, SSF160481, 1 hit
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50013, CHROMO_2, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q09XV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN
60 70 80 90 100
QDGGGGDVGN SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT
110 120 130 140 150
SQEQPAQPVL QTSTPTAGLL QVSKSQEILS QGNPFMGVSA TGVSPSNTGG
160 170 180 190 200
QPSQSAPKIV ILKAPPNSSV TGTHVAQIQA QGITSTAQPL VAGTANGGKV
210 220 230 240 250
TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ PSRPVKQLVL
260 270 280 290 300
QPVKGSAPAG NPGAAGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
310 320 330 340 350
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK
360 370 380 390 400
IQIVPQPPSS QPQPQPQPPP SAQPLTLSSV QQAQIMGPGQ NPGQRLSVPL
410 420 430 440 450
KMVLQPQAGS SQGASSGLSV VKVLSASEVA ALSSPASCAP HTAGKTGMEE
460 470 480 490 500
NRRLEHQKKQ EKANRIVAEA IARARARGEQ NIPRVLNEDE LPSVRPEEEG
510 520 530 540 550
EKKRRKKSSG ERLKEEKPKK SKTAAASKTK GKSKLNTITP VVGKKRKRNT
560 570 580 590 600
SSDNSDVEVM PAQSPREDEE SSIQKRRSNR QVKRKKYTED LDIKITDDEE
610 620 630 640 650
EEEVDVTGPI KPEPILPEPV QEPDGETLPS MQFFVENPSE EDAAIVDKVL
660 670 680 690 700
SMRVVKKELP SGQYTEAEEF FVKYKNYSYL HCEWATISQL EKDKRIHQKL
710 720 730 740 750
KRFKTKMAQM RHFFHEDEEP FNPDYVEVDR ILDESHSVDK DNGEPVIYYL
760 770 780 790 800
VKWCSLPYED STWELKEDVD EGKIREFKRI QSRHPELRRV NRPQANAWKK
810 820 830 840 850
LELSHEYKNR NQLREYQLEG VNWLLFNWYN RQNCILADEM GLGKTIQSIA
860 870 880 890 900
FLQEVYNVGI HGPFLVIAPL STITNWEREF NTWTEMNTIV YHGSLASRQM
910 920 930 940 950
IQQYEMYCKD SRGRLIPGAY KFDALITTFE MILSDCPELR EIEWRCVIID
960 970 980 990 1000
EAHRLKNRNC KLLDSLKHMD LEHKVLLTGT PLQNTVEELF SLLHFLEPSQ
1010 1020 1030 1040 1050
FPSESEFLKD FGDLKTEEQV QKLQAILKPM MLRRLKEDVE KNLAPKQETI
1060 1070 1080 1090 1100
IEVELTNIQK KYYRAILEKN FSFLSKGAGH TNMPNLLNTM MELRKCCNHP
1110 1120 1130 1140 1150
YLINGAEEKI LMEFREACHI IPQDFHLQAM VRSAGKLVLI DKLLPKLKAG
1160 1170 1180 1190 1200
GHKVLIFSQM VRCLDILEDY LIQRRYLYER IDGRVRGNLR QAAIDRFSKP
1210 1220 1230 1240 1250
DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ AQARCHRIGQ
1260 1270 1280 1290 1300
SKAVKVYRLI TRNSYEREMF DKASLKLGLD KAVLQSMSGR DGNITGIQQF
1310 1320 1330 1340 1350
SKKEIEDLLR KGAYAAIMEE DDEGSKFCEE DIDQILLRRT TTITIESEGK
1360 1370 1380 1390 1400
GSTFAKASFV ASENRTDISL DDPNFWQKWA KKADLDMDLL NSKNNLVIDT
1410 1420 1430 1440 1450
PRVRKQTRHF STLKDDDLVE FSDLESEDDE RPRSRRHDRH HTYGRTDCFR
1460 1470 1480 1490 1500
VEKHLLVYGW GRWRDILSHG RFKRRMTERD VETICRAILV YCLLHYRGDE
1510 1520 1530 1540 1550
NIKSFIWDLI SPAENGKTKE LQNHSGLSIP VPRGRKGKKV KSQSTFDIHK
1560 1570 1580 1590 1600
ADWIRKYNPD TLFQDESYKK HLKHQCNKVL LRVRMLYYLR QEVIGDQAEK
1610 1620 1630 1640 1650
VLGGAIASEI DIWFPVVDQL EVPTTWWDSE ADKSLLIGVF KHGYEKYNTM
1660 1670 1680 1690 1700
RADPALCFLE KAGRPDDKAI AAEHRVLDNF SDLVEGIDFD KDCEDPEYKP
1710 1720 1730 1740 1750
LQGPPKDPDD EGDPLMMMDE EISVIDGEEA QVTQQPGHLF WPPGSALTAR
1760 1770 1780 1790 1800
LRRLVTAYQR SYKREQMKME AAERGDRRRR RCEAAFKLKE IARREKQQRW
1810 1820 1830 1840 1850
TRREQTDFYR VVSTFGVEYD PDNMQFHWDR FRTFARLDKK TDESLTKYFH
1860 1870 1880 1890 1900
GFVAMCRQVC RLPPAAGDEP PDPNLFIEPI TEERASRTLY RIELLRRLRE
1910 1920 1930 1940 1950
QVLCHPLLED RLALCQPPGL ELPKWWEPVR HDGELLRGAA RHGVSQTDCN
1960 1970 1980 1990 2000
IMQDPDFSFL AARMNYMQNH QAGASAASLS RCSTPLLHQQ CTSRTASPSP
2010 2020 2030 2040 2050
LRPDAPVEKS PEESTVQVPN LESLTLKLED EVVARSRLTS QDYEVRVGSS
2060 2070 2080 2090 2100
DTAPLSRSVP PVKLEDEDDS DSELDLSKLS PSSSSSSSSS SSSSSTDESE
2110 2120 2130 2140 2150
DEKEEKLTAD RSRPKLYDEE SLLSLTMSQD GFPNEDGEQM TPELLLLQER
2160 2170 2180 2190 2200
QRASEWPKDR VLINRIDLVC QAVLSGKWPS NRRSQEVTAG GILGPGNHLL
2210 2220 2230 2240 2250
DSPSLTPGED GDSPVPTPRS GSAASMAEEE ASAVTTAAAQ FTKLRRGMDE
2260 2270 2280 2290 2300
KEFTVQIKDE EGLKLTFQKH RLMANGVMGD GHPLFHKKKG NRKKLVELEV
2310 2320 2330 2340 2350
ECMEEPNHLD LDLETRIPVI NKVDGTLLVG DEAPRRAELE MWLQGHPEFA
2360 2370 2380 2390 2400
VDPRFLAYME ERRKQKWQRC KKNNKAELNC LGMEPVQPAN SRNGKKGHYA
2410 2420 2430 2440 2450
ETAFNRVLPG PVAPENSKKR VRRTRPDLSK MMALMQGGST GSLSLHNTFQ
2460 2470 2480 2490 2500
HSSSNLQSVS SLGHSSTTSA SLPFMPFVMG AAAPPHVDSS TMLHHHHHHP
2510 2520 2530 2540 2550
HPHHHHHHHP GLRTTGYPSS PATTTSGTAL RLPTLQPEDD DEEEDEEDDD
2560 2570 2580
LSQGYDSSER DFSLIDDPMM PANSDSSEDA DD
Length:2,582
Mass (Da):290,847
Last modified:October 17, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9432500F6A8C329
GO
Isoform 2 (identifier: Q09XV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-751: PVIYYLV → VSWARRT
     752-2582: Missing.

Show »
Length:751
Mass (Da):80,950
Checksum:i23F272C1595F2A90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AL76F7AL76_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd8
1,031Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRI1A0A2I3BRI1_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd8
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BR97A0A2I3BR97_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd8
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98203 differs from that shown. Partially unspliced pre-RNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21T → A in AAW56421 (PubMed:15367660).Curated1
Sequence conflicti2020N → S in BAC98203 (PubMed:14621295).Curated1
Sequence conflicti2298L → V in BAC98203 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036676745 – 751PVIYYLV → VSWARRT in isoform 2. 1 Publication7
Alternative sequenceiVSP_036677752 – 2582Missing in isoform 2. 1 PublicationAdd BLAST1831

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ190419 mRNA Translation: ABB02259.1
AY863219 mRNA Translation: AAW56421.1
AK129393 Transcribed RNA Translation: BAC98203.2 Sequence problems.
AK160299 mRNA Translation: BAE35730.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36919.1 [Q09XV5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_963999.2, NM_201637.2 [Q09XV5-1]
XP_006519539.1, XM_006519476.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000089752; ENSMUSP00000087184; ENSMUSG00000053754 [Q09XV5-1]
ENSMUST00000200169; ENSMUSP00000142890; ENSMUSG00000053754 [Q09XV5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67772

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67772

UCSC genome browser

More...
UCSCi
uc007tot.1, mouse [Q09XV5-1]
uc007tov.1, mouse [Q09XV5-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ190419 mRNA Translation: ABB02259.1
AY863219 mRNA Translation: AAW56421.1
AK129393 Transcribed RNA Translation: BAC98203.2 Sequence problems.
AK160299 mRNA Translation: BAE35730.1
CCDSiCCDS36919.1 [Q09XV5-1]
RefSeqiNP_963999.2, NM_201637.2 [Q09XV5-1]
XP_006519539.1, XM_006519476.3

3D structure databases

SMRiQ09XV5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212432, 17 interactors
IntActiQ09XV5, 4 interactors
STRINGi10090.ENSMUSP00000087184

PTM databases

iPTMnetiQ09XV5
PhosphoSitePlusiQ09XV5

Proteomic databases

EPDiQ09XV5
jPOSTiQ09XV5
MaxQBiQ09XV5
PaxDbiQ09XV5
PeptideAtlasiQ09XV5
PRIDEiQ09XV5
ProteomicsDBi281607 [Q09XV5-1]
281608 [Q09XV5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
73, 121 antibodies

Genome annotation databases

EnsembliENSMUST00000089752; ENSMUSP00000087184; ENSMUSG00000053754 [Q09XV5-1]
ENSMUST00000200169; ENSMUSP00000142890; ENSMUSG00000053754 [Q09XV5-1]
GeneIDi67772
KEGGimmu:67772
UCSCiuc007tot.1, mouse [Q09XV5-1]
uc007tov.1, mouse [Q09XV5-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57680
MGIiMGI:1915022, Chd8

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0384, Eukaryota
GeneTreeiENSGT00940000153649
InParanoidiQ09XV5
OMAiQANAWKK
OrthoDBi7181at2759
TreeFamiTF313572

Enzyme and pathway databases

ReactomeiR-MMU-3769402, Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67772, 15 hits in 56 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Chd8, mouse

Protein Ontology

More...
PROi
PR:Q09XV5
RNActiQ09XV5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053754, Expressed in embryonic post-anal tail and 324 other tissues
ExpressionAtlasiQ09XV5, baseline and differential
GenevisibleiQ09XV5, MM

Family and domain databases

Gene3Di2.20.28.130, 1 hit
3.40.50.10810, 1 hit
HAMAPiMF_03071, CHD8, 1 hit
InterProiView protein in InterPro
IPR006576, BRK_domain
IPR037259, BRK_sf
IPR034724, CHD8
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF07533, BRK, 1 hit
PF00385, Chromo, 2 hits
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592, BRK, 2 hits
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF160481, SSF160481, 1 hit
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013, CHROMO_2, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09XV5
Secondary accession number(s): Q3TV89, Q5I1Z2, Q6ZPM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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