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Protein

Uracil nucleotide/cysteinyl leukotriene receptor

Gene

Gpr17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.1 Publication

Miscellaneous

Administration of an antisense oligonucleotide specific for GPR17 significantly reduced brain damage following ischemia.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GO_Central
  • receptor serine/threonine kinase binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906 Leukotriene receptors
R-RNO-416476 G alpha (q) signalling events
R-RNO-417957 P2Y receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil nucleotide/cysteinyl leukotriene receptor
Short name:
UDP/CysLT receptor
Alternative name(s):
G-protein coupled receptor 17
Gene namesi
Name:Gpr17Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1589785 Gpr17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 64CytoplasmicSequence analysis7
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 105ExtracellularSequence analysisAdd BLAST20
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 147CytoplasmicSequence analysisAdd BLAST21
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 195ExtracellularSequence analysisAdd BLAST27
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 232CytoplasmicSequence analysisAdd BLAST16
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 280ExtracellularSequence analysisAdd BLAST27
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 339CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002781721 – 339Uracil nucleotide/cysteinyl leukotriene receptorAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ09QM4

PTM databases

PhosphoSitePlusiQ09QM4

Expressioni

Tissue specificityi

Expressed in brain, kidney, and heart. Highest level in brain.1 Publication

Inductioni

In brain areas affected by ischemia.1 Publication

Gene expression databases

BgeeiENSRNOG00000025745

Interactioni

GO - Molecular functioni

  • receptor serine/threonine kinase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032046

Structurei

3D structure databases

ProteinModelPortaliQ09QM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZC Eukaryota
ENOG41110RZ LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG102010
InParanoidiQ09QM4
KOiK08404
OMAiFSGNHWP
OrthoDBiEOG091G0A8K
PhylomeDBiQ09QM4
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q09QM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGLETALPS LTDNASLAYS EQCGQETPLE NMLFACFYLL DFILAFVGNA
60 70 80 90 100
LALWLFIWDH KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG
110 120 130 140 150
EIPCRLTGFL FYLNMYASIY FLTCISADRF LAIVHPVKSL KLRRPLYAHL
160 170 180 190 200
ACAFLWIVVA VAMAPLLVSP QTVQTNHTVV CLQLYREKAS HHALASLAVA
210 220 230 240 250
FTFPFITTVT CYLLIIRSLR QGPRIEKHLK NKAVRMIAMV LAIFLICFVP
260 270 280 290 300
YHIHRSVYVL HYRGGGTSCS AQRALALGNR ITSCLTSLNG ALDPVMYFFV
310 320 330
AEKFRHALCN LLCSKRLTGP PPSFEGKTNE SSLSARSEL
Length:339
Mass (Da):37,870
Last modified:October 17, 2006 - v1
Checksum:i19239CC3EE0C11D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ777767 mRNA Translation: ABG75921.1
RefSeqiNP_001065245.1, NM_001071777.1
XP_006254666.1, XM_006254604.3
UniGeneiRn.212749

Genome annotation databases

EnsembliENSRNOT00000036537; ENSRNOP00000032046; ENSRNOG00000025745
GeneIDi767613
KEGGirno:767613
UCSCiRGD:1589785 rat

Similar proteinsi

Entry informationi

Entry nameiGPR17_RAT
AccessioniPrimary (citable) accession number: Q09QM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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