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Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF-alpha

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNF-alphaImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 187TNF_2InterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Phylogenomic databases

eggNOGiENOG410ISAN Eukaryota
ENOG410YQC4 LUCA
HOVERGENiHBG012516

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q09H04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LSLFSFLLVA GATTLFCLLH FGVIGPQREE FPKDPSLISP LAQAVRSSSR
60 70 80 90 100
TPSDKPVAHV VANPQAEGQL QWLNRRANAL LANGVELTDN QLVVPSEGLY
110 120 130 140 150
LIYSQVLFKG QGCPSNHVLL THTISRIAVS YQTKVNLLSA IKSPCQRETP
160 170 180
EGAEAKPWYE PIYLGGVFQL EKGDRLSAEI NLPDYLD
Length:187
Mass (Da):20,498
Last modified:October 17, 2006 - v1
Checksum:i1049C3D0206C64E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei187Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ902441 mRNA Translation: ABI63774.1
DQ902455 mRNA Translation: ABI63788.1
DQ902458 mRNA Translation: ABI63791.1
DQ902465 mRNA Translation: ABI63798.1
DQ902466 mRNA Translation: ABI63799.1
DQ902470 mRNA Translation: ABI63803.1
DQ902473 mRNA Translation: ABI63806.1
DQ902476 mRNA Translation: ABI63809.1
UniGeneiMmu.3364

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ902441 mRNA Translation: ABI63774.1
DQ902455 mRNA Translation: ABI63788.1
DQ902458 mRNA Translation: ABI63791.1
DQ902465 mRNA Translation: ABI63798.1
DQ902466 mRNA Translation: ABI63799.1
DQ902470 mRNA Translation: ABI63803.1
DQ902473 mRNA Translation: ABI63806.1
DQ902476 mRNA Translation: ABI63809.1
UniGeneiMmu.3364

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410ISAN Eukaryota
ENOG410YQC4 LUCA
HOVERGENiHBG012516

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ09H04_MACMU
AccessioniPrimary (citable) accession number: Q09H04
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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