UniProtKB - Q09GK1 (VSP_PHIOL)
Protein
Snake venom serine protease
Gene
N/A
Organism
Philodryas olfersii (Green snake)
Status
Functioni
Snake venom serine protease that may act in the hemostasis system of the prey.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 65 | Charge relay systemBy similarity | 1 | |
Active sitei | 110 | Charge relay systemBy similarity | 1 | |
Active sitei | 204 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hemostasis impairing toxin, Hydrolase, Protease, Serine protease, Toxin |
Protein family/group databases
MEROPSi | S01.481 |
Names & Taxonomyi
Protein namesi | |
Organismi | Philodryas olfersii (Green snake) |
Taxonomic identifieri | 120305 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Dipsadidae › Philodryas |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000296370 | 21 – 24 | By similarity | 4 | |
ChainiPRO_0000296371 | 25 – 261 | Snake venom serine proteaseAdd BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 163 | PROSITE-ProRule annotation | ||
Disulfide bondi | 50 ↔ 66 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 256 | PROSITE-ProRule annotation | ||
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 210 | PROSITE-ProRule annotation | ||
Disulfide bondi | 174 ↔ 189 | PROSITE-ProRule annotation | ||
Disulfide bondi | 200 ↔ 225 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Monomer.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 249 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 225 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q09GK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALIGVLANL LILCLSYART APDRIIGGLE CNQNEHRSLV LLYNSGGFFC
60 70 80 90 100
SGTLINHEWV LTAAHCNREN IQIKLGVHNI HVPNEDEQIR VPKEKVCCLG
110 120 130 140 150
TMNCTQWNQD IMLIRLNSSV NYSTHIAPLS LPSNPPSVGS VCRVMGWGTI
160 170 180 190 200
TSPEVTYPEV PHCVNIQILH KELCEAAYPI LLGNSNILCA GKLLGDKDSC
210 220 230 240 250
KGDSGGPLIC NGQIQGIVSW GGFPCAQILE PGVYTKVFDY IDWIQDIMAG
260
NANVICPGDN F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ912657 mRNA Translation: ABI74694.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ912657 mRNA Translation: ABI74694.1 |
3D structure databases
SMRi | Q09GK1 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S01.481 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VSP_PHIOL | |
Accessioni | Q09GK1Primary (citable) accession number: Q09GK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | October 17, 2006 | |
Last modified: | August 12, 2020 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families