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UniProtKB - Q09917 (PKD2_SCHPO)
Protein
TRP-like ion channel pkd2
Gene
pkd2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Acts as a key signaling component in the regulation of cell shape and cell wall synthesis through interaction with GTPase Rho1.
1 PublicationGO - Molecular functioni
- calcium channel activity Source: PomBase
- mechanosensitive cation channel activity Source: PomBase
GO - Biological processi
- calcium ion import across plasma membrane Source: PomBase
- cellular water homeostasis Source: PomBase
- fungal-type cell wall biogenesis Source: GO_Central
- release of sequestered calcium ion into cytosol by Golgi Source: PomBase
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Calcium channel, Ion channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Protein family/group databases
TCDBi | 1.A.4.9.2, the transient receptor potential ca(2+) channel (trp-cc) family |
Names & Taxonomyi
Protein namesi | Recommended name: TRP-like ion channel pkd2Alternative name(s): Polycystic kidney disease-related ion channel 2 |
Gene namesi | Name:pkd2 ORF Names:SPAC1F7.03 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC1F7.03, pkd2 |
VEuPathDBi | FungiDB:SPAC1F7.03 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- cleavage furrow Source: PomBase
- integral component of plasma membrane Source: PomBase
- plasma membrane of cell tip Source: PomBase
Other locations
- integral component of membrane Source: GO_Central
- transport vesicle Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 404 – 424 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 492 – 512 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 525 – 545 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 555 – 575 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000045821 | 24 – 710 | TRP-like ion channel pkd2Add BLAST | 687 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 599 | Phosphoserine1 Publication | 1 | |
Modified residuei | 632 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q09917 |
PRIDEi | Q09917 |
PTM databases
iPTMneti | Q09917 |
Interactioni
Subunit structurei
Interacts with rho1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 278110, 4 interactors |
STRINGi | 4896.SPAC1F7.03.1 |
Structurei
3D structure databases
AlphaFoldDBi | Q09917 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 689 – 710 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 693 – 710 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the transient receptor potential (TRP) ion channel family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSVZ, Eukaryota |
HOGENOMi | CLU_010226_1_0_1 |
InParanoidi | Q09917 |
OMAi | FLYVQFK |
PhylomeDBi | Q09917 |
Family and domain databases
InterProi | View protein in InterPro IPR010308, TRP_C IPR040241, TRP_Flc/Pkd2-like IPR032800, TRP_N |
PANTHERi | PTHR31145, PTHR31145, 1 hit |
Pfami | View protein in Pfam PF06011, TRP, 1 hit PF14558, TRP_N, 1 hit |
SMARTi | View protein in SMART SM01320, TRP_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q09917-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLWRSPLLL LVVVVELFSW ADALTRFISA DSLSTCMTDS QLSASKLYAS
60 70 80 90 100
YFPDNQSVAF DISIQSLVST NVSIDVDISA YGIEIKKVID PCDMEISGFC
110 120 130 140 150
PMQTGNIALS GSHTLTGEAL SILDSIPSIA YTVPDLDAVV TINIYESDTN
160 170 180 190 200
TQLACVRTTV QNGRSVYHRA VYWVMCMVIG IPLLIFLLIS PVLQTPALWE
210 220 230 240 250
IVETMITLFQ FAQIQALYSM MATSLPAIIY SWGRNFMWSM GIIRIGFMQD
260 270 280 290 300
VFTWYVKSTG GTPSTLVDLG IHANVALAKR GIDLGSLAKR ATTTVTTSTS
310 320 330 340 350
DSITLRGIKR ISYMMGIETT NFFATGFSFF IILLFFSLLV AMASRFIVEM
360 370 380 390 400
VLLASRNQAL KKQRIRLYWK SISKGFFYRV IFVGFTQMSV LSMWEIYTRD
410 420 430 440 450
SSALAFLSMY VIVDMAVLLC YAFVRTIQII RKTGPYSHPD VLYNLYSDTQ
460 470 480 490 500
HLMRWGFMYV QLDVRFFYFT FPLLLITLVR SMFIGFGQGS PKVQGCAMFG
510 520 530 540 550
ISVVVFALMV ILRPYATKHM NTLHIGVALM NLISGSFILV MCQAFYVEEL
560 570 580 590 600
ARQVIGIIFF ALNAITMLLL ILGIFIRTLI VLFRKSGHGT YYRILDDQSE
610 620 630 640 650
KATSYNKSIK DMSSSDMAFS DPAYSGTTLR SSVDLNTPEY PFSNRNDSDS
660 670 680 690 700
TFTNNKYVSP WDAIEEASYA NLRGNTDVEQ PFMESDYTRI SENNNNAERR
710
RKPLPNNAFR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAA91950.1 |
PIRi | S62575 |
RefSeqi | NP_594489.1, NM_001019918.2 |
Genome annotation databases
EnsemblFungii | SPAC1F7.03.1; SPAC1F7.03.1:pep; SPAC1F7.03 |
GeneIDi | 2541613 |
KEGGi | spo:SPAC1F7.03 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAA91950.1 |
PIRi | S62575 |
RefSeqi | NP_594489.1, NM_001019918.2 |
3D structure databases
AlphaFoldDBi | Q09917 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 278110, 4 interactors |
STRINGi | 4896.SPAC1F7.03.1 |
Protein family/group databases
TCDBi | 1.A.4.9.2, the transient receptor potential ca(2+) channel (trp-cc) family |
PTM databases
iPTMneti | Q09917 |
Proteomic databases
PaxDbi | Q09917 |
PRIDEi | Q09917 |
Genome annotation databases
EnsemblFungii | SPAC1F7.03.1; SPAC1F7.03.1:pep; SPAC1F7.03 |
GeneIDi | 2541613 |
KEGGi | spo:SPAC1F7.03 |
Organism-specific databases
PomBasei | SPAC1F7.03, pkd2 |
VEuPathDBi | FungiDB:SPAC1F7.03 |
Phylogenomic databases
eggNOGi | ENOG502QSVZ, Eukaryota |
HOGENOMi | CLU_010226_1_0_1 |
InParanoidi | Q09917 |
OMAi | FLYVQFK |
PhylomeDBi | Q09917 |
Miscellaneous databases
PROi | PR:Q09917 |
Family and domain databases
InterProi | View protein in InterPro IPR010308, TRP_C IPR040241, TRP_Flc/Pkd2-like IPR032800, TRP_N |
PANTHERi | PTHR31145, PTHR31145, 1 hit |
Pfami | View protein in Pfam PF06011, TRP, 1 hit PF14558, TRP_N, 1 hit |
SMARTi | View protein in SMART SM01320, TRP_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKD2_SCHPO | |
Accessioni | Q09917Primary (citable) accession number: Q09917 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families