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Protein

Transcription elongation factor spt6

Gene

spt6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor spt6
Alternative name(s):
Chromatin elongation factor spt6
Gene namesi
Name:spt6
ORF Names:SPAC1F7.01c, SPAC694.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F7.01c
PomBaseiSPAC1F7.01c spt6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001164401 – 1365Transcription elongation factor spt6Add BLAST1365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137Phosphothreonine1 Publication1
Modified residuei143Phosphoserine1 Publication1
Modified residuei454Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09915
PaxDbiQ09915
PRIDEiQ09915

PTM databases

iPTMnetiQ09915

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278102, 9 interactors
IntActiQ09915, 1 interactor
STRINGi4896.SPAC1F7.01c.1

Structurei

3D structure databases

ProteinModelPortaliQ09915
SMRiQ09915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1050 – 1118S1 motifPROSITE-ProRule annotationAdd BLAST69
Domaini1167 – 1262SH2Add BLAST96

Sequence similaritiesi

Belongs to the SPT6 family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

HOGENOMiHOG000193710
InParanoidiQ09915
KOiK11292
OMAiEADWIYR
OrthoDBiEOG092C04AI
PhylomeDBiQ09915

Family and domain databases

CDDicd09928 SH2_Cterm_SPT6_like, 1 hit
cd09918 SH2_Nterm_SPT6_like, 1 hit
Gene3Di1.10.10.650, 1 hit
1.10.3500.10, 2 hits
3.30.420.140, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR012337 RNaseH-like_sf
IPR010994 RuvA_2-like
IPR022967 S1_dom
IPR003029 S1_domain
IPR036860 SH2_dom_sf
IPR028083 Spt6_acidic_N_dom
IPR027999 Spt6_dom
IPR032706 Spt6_HHH
IPR028088 Spt6_HTH_DNA-bd_dom
IPR035420 Spt6_SH2
IPR035018 Spt6_SH2_C
IPR035019 Spt6_SH2_N
IPR028231 Spt6_YqgF
IPR023323 Tex-like_dom_sf
IPR023319 Tex-like_HTH_dom_sf
IPR017072 TF_Spt6
IPR006641 YqgF/RNaseH-like_dom
IPR037027 YqgF/RNaseH-like_dom_sf
PANTHERiPTHR10145 PTHR10145, 1 hit
PfamiView protein in Pfam
PF14878 DLD, 1 hit
PF14635 HHH_7, 1 hit
PF14641 HTH_44, 1 hit
PF00575 S1, 1 hit
PF14633 SH2_2, 1 hit
PF14632 SPT6_acidic, 1 hit
PF14639 YqgF, 1 hit
PIRSFiPIRSF036947 Spt6, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SM00732 YqgFc, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF50249 SSF50249, 1 hit
SSF53098 SSF53098, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q09915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSENEVVGSP TTNGDKNEDG YPAENGEGTN VDDNNNEEEK DGIPLDNDND
60 70 80 90 100
ENDSSEESAT DEEAERQVRE GFIVEDEEDE VPQEIRRKKK RKKHAESTAD
110 120 130 140 150
QDMLDEEDLE LVMENTGQGS RFSKLRRLKR GRDQEETLEN IFSEEEEEEE
160 170 180 190 200
NEVDDEAPNR TQGHRAGVID EFADFIEQDE FEDEERQEEK YETGPPIESV
210 220 230 240 250
RPEALGISDD DYIQIYEVFG DGTDYAFALE DEDAEDELEE SVSLKTIFEP
260 270 280 290 300
SELKDKMLTE EDEIIRITDE PERMQLYMKR NIDCSEDEFR EQVAWIIDYL
310 320 330 340 350
LKNRRDIDAE LYEPFQTAVR YVVHFFIRDS LEVPFIWQHR RDYIVHNNRE
360 370 380 390 400
RNTITPLLSQ NDLWNIFFLC TKFWSLHSKK QDILKLYSDL GINDDLVVPF
410 420 430 440 450
CEAASSLDAI DDLNDYIHFT YSEQIRDRAL LMGTGLRRPQ GSKYSFFEKF
460 470 480 490 500
RKSSLYNLVK EFGMSAKDFS FNVAQGARLR FVEDNTLSPE ELSRTYVTNE
510 520 530 540 550
LSSPEQVLQK ARRVLAEEII HDPQFRKSFR DKLYNAGVVT VLATQKGVRK
560 570 580 590 600
IGSEHPYYEF KYLKRKPLGS FELEPILFLK MLKAEEEGLI QLSIEFEDPD
610 620 630 640 650
DVFKGLLELF VSDNFSENAM QWNAQRELVL KEVFKRFSAL APDAIRETLR
660 670 680 690 700
SRYLDELGMR CRNQLFSRLD QAPYEPSTKN FDRGTIPSVL AVSNGKGESS
710 720 730 740 750
DAIICVFVDD VGEPTDSLKL ADLRDLANQA MFAEFVEKVK PDVIGVSGMS
760 770 780 790 800
VSAHKIRQHV QDSLTSHEPV DLIMVNDEVA RLYQNSTRAV DEFPTLPTIS
810 820 830 840 850
CYCVALARYV QNPLFEYAAM GRDLMSLSFD PWQHLLPPDV LWKYLETALV
860 870 880 890 900
DISSLVGIDI NEAVTNKYEA NILPYIAGLG PRKADYVLKK IAATGGRIDN
910 920 930 940 950
RSDLISKQIM SRKVFINCSS FFIIPNDEYP NMDILDSTRI HNEDYELARK
960 970 980 990 1000
MASDALELDE EDIEELETNR GVVYHLLEEN ETGKLDELVL EEYADQLERE
1010 1020 1030 1040 1050
FHQKKRNTLE KIRLELKDPY GEQRNVFHKL TPSEIFLMLT GENPEELQAD
1060 1070 1080 1090 1100
AIVPVNVRRV TNRFVAVKLD CGIDGNIKAD EVSDDFIPPP QLLQVGQTVE
1110 1120 1130 1140 1150
GVIISLDEAN FMVDLSLRNS VLQSANSKRQ TSSHRTSYWD TEAEKRDTER
1160 1170 1180 1190 1200
MQAETQAEQR VARVIKHPLF KDLNASQAEA YLSKMQVGDL VIRPSSKGSD
1210 1220 1230 1240 1250
HIVVTWKVAE GSYQHIDVLE LEKENEFTIG QKLLVKGRFE KMTYQYSDLD
1260 1270 1280 1290 1300
ELIVLHIKAI AKKIDEMCIH DKFRKGTQAE TEKWLESYSE ANPKRSCYAF
1310 1320 1330 1340 1350
CFDHQHPGYF ILCFKASVNS PVTAWPVKVI PNAFFLQGNV YGDMTALCNG
1360
FKLLYAARTK NFRRM
Length:1,365
Mass (Da):157,210
Last modified:August 29, 2001 - v2
Checksum:i0E6DB64E25667A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB71845.1
PIRiT38095 S62573
T50252
RefSeqiNP_594487.2, NM_001019916.2

Genome annotation databases

EnsemblFungiiSPAC1F7.01c.1; SPAC1F7.01c.1:pep; SPAC1F7.01c
GeneIDi2541605
KEGGispo:SPAC1F7.01c

Similar proteinsi

Entry informationi

Entry nameiSPT6_SCHPO
AccessioniPrimary (citable) accession number: Q09915
Secondary accession number(s): Q9P7T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 29, 2001
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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