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UniProtKB - Q09847 (NU146_SCHPO)

Entry version 120 (10 Feb 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Nucleoporin nup146

Gene

nup146

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin nup146
Alternative name(s):
Nuclear pore protein nup146
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup146
ORF Names:SPAC23D3.06c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPAC23D3.06c, nup146

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPAC23D3.06c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001164181 – 1325Nucleoporin nup146Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei899Phosphothreonine1 Publication1
Modified residuei946Phosphothreonine1 Publication1
Modified residuei1041Phosphoserine1 Publication1
Modified residuei1043Phosphoserine1 Publication1
Modified residuei1044Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q09847

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q09847

PRoteomics IDEntifications database

More...PRIDEi		Q09847

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q09847

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		278009, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q09847, 1 interactor

STRING: functional protein association networks

More...STRINGi		4896.SPAC23D3.06c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3630, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_257817_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q09847

Identification of Orthologs from Complete Genome Data

More...OMAi		GIPGQIE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q09847

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039462, Nup159/Nup146_N
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16755, NUP214, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09847-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAENTFSIL NTNEPNAGGS QVTESEIEEE DIEFLSFAAL KIGATSSLSN 
        60         70         80         90        100
SSLGLPEYSN LFAINNLKSL FVAGVPNYLI IGSTLDLQKS LIDADENVDA 
       110        120        130        140        150
NVLKDSASIR HVSLPDAKFS MVSFSSNGEF VIAYDFVSFE LSVYETDALL 
       160        170        180        190        200
KNSATSIYKA VFPDLVQVLP NPEINNLVIL RNLKLEVFLL SLSKFQVESP 
       210        220        230        240        250
LAKDATCAAW SRRGKQCVIG FNNGTMSQYT PAGEIKLRIP RPPSLENYFV 
       260        270        280        290        300
ECISWIENRE FVVFYSPLTS LSNESDEPPH ESECFVISVG MNGHFNFGKA 
       310        320        330        340        350
GDPTPPFGAV NRRDHHYIAS LHAWKPDLRS LVVVANTASA DLGVLALSME 
       360        370        380        390        400
KNQWSILNIV DETKRASLPY SNKKDSDSSP TALVMDFTAT DRISKPLDPT 
       410        420        430        440        450
EAPADCSPLP IVWVFNDEFQ LVAYRIFYAD AISKSIDYPE MNVIKDKNKD 
       460        470        480        490        500
STVRASNNEN IPTPDKQASP FVKNLSSTSS PFSQSSAFGN FKFGQATSFD 
       510        520        530        540        550
KGLSTDASSG AKSNTPVFGQ PSTFGQAPVF GQPSAFGQAP VFGQPSAFGQ 
       560        570        580        590        600
SSFSFGTSNM NQKLDFGTFK SPLSGAATGE AKTNLEKAVT SASGKASFTG 
       610        620        630        640        650
FAPSQSTTSG LNFDSIPKDN EAASIFGSSQ VSTKNTSGFQ FSNNTLLADN 
       660        670        680        690        700
VDEDIESDHD TKIEELANSD VEPSTEQNIG GDVSWGASTF QSKPQPSFSF 
       710        720        730        740        750
GLTLDDKSNT PGKNFSIFGK TAETQVEQKK PENNVLTKPF SFAPSDKSMF 
       760        770        780        790        800
AANIPSAGEG LDQQKTSKAL PSTGITKLSE NDNEKAEESN ETKGFNTTIA 
       810        820        830        840        850
KQNDKSSKSE GKASVANMSA LNKSTNNETS DSKPSLKSPL FNFSADAPTF 
       860        870        880        890        900
TFNKPSETPP FSFNKPLVEK ESKQDVSDTS DRSPFSFKAF GIDSKKSPTP 
       910        920        930        940        950
EPTEMAESNI SEESEGWKLI EQPNVESEIE DQDEESSDLN GKRRSTPPKI 
       960        970        980        990       1000
HEVGVNKMLD VVPKEKRDLN SFFPKQPLVV QSTDKNKKEP QESLEDEILS 
      1010       1020       1030       1040       1050
AEGFSEVEAA NKISRFEPFS SPKLKLATSD NAPEKYVFEE SESSDLEEGP 
      1060       1070       1080       1090       1100
VPLRNLESLA DLPEAESNEK LPMVNTFERL YLQFKNELDL VWQNINIIAE 
      1110       1120       1130       1140       1150
YIEGQTSTPS AVSEQATMAM LSQNTEELED LLDTVTSFSA FCSDYSKQID 
      1160       1170       1180       1190       1200
YLEACLVRIN AKRIQVTRLL KALTNPAFEK QMELRQLGPE ALRRQKELRL 
      1210       1220       1230       1240       1250
KMEKVLKSLS TLEQQAVDAR MSDTRRFKKP TLGSIEVAYS RIATLLGQRL 
      1260       1270       1280       1290       1300
KQLYKLEKDI KRMATKKKMI TKKSMSSDMM TQFRALGISQ SSTKQVSAHY 
      1310       1320 
LREFERQDAF RNGVFKRLTS LKKAD
Length:1,325
Mass (Da):145,777
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEFD952FB7F0E6BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91241.1

Protein sequence database of the Protein Information Resource

More...PIRi		S62497

NCBI Reference Sequences

More...RefSeqi		NP_594543.1, NM_001019972.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPAC23D3.06c.1; SPAC23D3.06c.1:pep; SPAC23D3.06c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2541507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPAC23D3.06c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91241.1
PIRiS62497
RefSeqiNP_594543.1, NM_001019972.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi278009, 1 interactor
IntActiQ09847, 1 interactor
STRINGi4896.SPAC23D3.06c.1

PTM databases

iPTMnetiQ09847

Proteomic databases

MaxQBiQ09847
PaxDbiQ09847
PRIDEiQ09847

Genome annotation databases

EnsemblFungiiSPAC23D3.06c.1; SPAC23D3.06c.1:pep; SPAC23D3.06c
GeneIDi2541507
KEGGispo:SPAC23D3.06c

Organism-specific databases

PomBaseiSPAC23D3.06c, nup146
VEuPathDBiFungiDB:SPAC23D3.06c

Phylogenomic databases

eggNOGiKOG3630, Eukaryota
HOGENOMiCLU_257817_0_0_1
InParanoidiQ09847
OMAiGIPGQIE
PhylomeDBiQ09847

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q09847

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039462, Nup159/Nup146_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF16755, NUP214, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU146_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09847
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 10, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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