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Entry version 125 (10 Feb 2021)
Sequence version 2 (21 Mar 2012)
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Protein

Calcium permeable stress-gated cation channel 1

Gene

SPAC2G11.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium permeable stress-gated cation channel 1
Short name:
SpCSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPAC2G11.09
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC2G11.09

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC2G11.09

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21LumenalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 95CytoplasmicSequence analysisAdd BLAST53
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 192LumenalSequence analysisAdd BLAST76
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 444CytoplasmicSequence analysisAdd BLAST231
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 493LumenalSequence analysisAdd BLAST28
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 534CytoplasmicSequence analysisAdd BLAST20
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Topological domaini556 – 577LumenalSequence analysisAdd BLAST22
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 646CytoplasmicSequence analysisAdd BLAST48
Transmembranei647 – 667HelicalSequence analysisAdd BLAST21
Topological domaini668 – 687LumenalSequence analysisAdd BLAST20
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Topological domaini709 – 713CytoplasmicSequence analysis5
Transmembranei714 – 734HelicalSequence analysisAdd BLAST21
Topological domaini735 – 793LumenalSequence analysisAdd BLAST59

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001164111 – 793Calcium permeable stress-gated cation channel 1Add BLAST793

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q09809

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09809

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q09809

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4896.SPAC2G11.09.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q09809

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1134, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002458_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09809

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLWVHTI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR035979, RBD_domain_sf
IPR003864, RSN1_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09809-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFNGYGIFD SDPRKNPSSD LRTQFWLAFL LGASACVFFC FFRKRWKVLY
60 70 80 90 100
APRTTIEGLN LPTLSSSYYK WLMDLVNIPD DVVQNCAGLD GYVFLLFFKM
110 120 130 140 150
GIKFLSFASL LGVLIIMPVN KHFRGDAFGN ITLSMPAKSE YFFSSPLVKK
160 170 180 190 200
SIVQSPIIAN GSELNVGVLG PSLFNPIGNL SDIPGLPQPG DGFLYLYVLF
210 220 230 240 250
TYFISIFLLY VLFSSTKSIA DIRQSYLARQ NRLTDRTVFI SGLPNELCST
260 270 280 290 300
ENLKAYFDKL DVGSIDSLSI CRNYSYMDIL LSKKSKYVKK LEKYWSIYLS
310 320 330 340 350
NCKKLGISTL PPSNYLSPNR AELESTPEQL LEVPWQHHQC HPLIKTHFFG
360 370 380 390 400
IFGQKIDAID FYSAKLYKIS QQIENARSFD YPTTGQAFIT FESMATAQIV
410 420 430 440 450
AQTHIDSKSL MGLHIELAPA ANDIQWHNTY IGRWHKFFQG WFITLVTFMI
460 470 480 490 500
ILLWTVPVGA IAVFINLDTI RRLWPELGRM IEDLPFLNSL LRTFLPTLVY
510 520 530 540 550
SLFISISPFL FRWLSSMQGL SSRAEEEIYA VGKNYAYLFV NFFLVYVIAG
560 570 580 590 600
STSIWELAKD TTSFAHFLAN RLPHQAQFFI DLIVLQGIGM FPLKLIQLGK
610 620 630 640 650
LSSYFVRRSF VPYSIASKKF ETPDSFSVGI FLPQPMFIML ICLCYSIISP
660 670 680 690 700
LILVFGLIYF IIGFLVYKYE LIYQMEHPQH STGELWSTIF LRMIFGCVIM
710 720 730 740 750
QLTMMGLMSL RKAYWLSTVI FPLLCFTVIS AYNFSTMIRS SMQFVSLYYI
760 770 780 790
RTHQSNTLSS ESESRNSESS GSYVHPGFDL SNEELPLIDL NTA
Length:793
Mass (Da):90,573
Last modified:March 21, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEF42C2B494B7910
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91174.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T38575, S62464

NCBI Reference Sequences

More...
RefSeqi
NP_593089.2, NM_001018487.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC2G11.09.1; SPAC2G11.09.1:pep; SPAC2G11.09

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC2G11.09

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91174.2
PIRiT38575, S62464
RefSeqiNP_593089.2, NM_001018487.2

3D structure databases

SMRiQ09809
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4896.SPAC2G11.09.1

PTM databases

iPTMnetiQ09809

Proteomic databases

MaxQBiQ09809
PaxDbiQ09809

Genome annotation databases

EnsemblFungiiSPAC2G11.09.1; SPAC2G11.09.1:pep; SPAC2G11.09
GeneIDi2541980
KEGGispo:SPAC2G11.09

Organism-specific databases

PomBaseiSPAC2G11.09
VEuPathDBiFungiDB:SPAC2G11.09

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
HOGENOMiCLU_002458_0_2_1
InParanoidiQ09809
OMAiWLWVHTI

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09809

Family and domain databases

InterProiView protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR035979, RBD_domain_sf
IPR003864, RSN1_7TM
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSC1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09809
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 21, 2012
Last modified: February 10, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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