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Entry version 127 (12 Aug 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Tuberous sclerosis 1 protein homolog

Gene

tsc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-165181, Inhibition of TSC complex formation by PKB
R-SPO-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-SPO-5628897, TP53 Regulates Metabolic Genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tuberous sclerosis 1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tsc1
ORF Names:SPAC22F3.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC22F3.13

Schizosaccharomyces pombe database

More...
PomBasei
SPAC22F3.13, tsc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000656531 – 899Tuberous sclerosis 1 protein homologAdd BLAST899

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q09778

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09778

PRoteomics IDEntifications database

More...
PRIDEi
Q09778

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q09778

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tsc2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278359, 89 interactors

Protein interaction database and analysis system

More...
IntActi
Q09778, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPAC22F3.13.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1899
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09778

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili540 – 706Sequence analysisAdd BLAST167
Coiled coili737 – 847Sequence analysisAdd BLAST111

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R01W, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_314266_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09778

Identification of Orthologs from Complete Genome Data

More...
OMAi
LYPINFM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09778

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR007483, Hamartin

The PANTHER Classification System

More...
PANTHERi
PTHR15154, PTHR15154, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04388, Hamartin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09778-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLQSLVKAL WNVLHEEESE GYPDLTELIA EVESYQQRYP KQNPTNSQKI
60 70 80 90 100
RHILDEIYEK TPFNNTRRRI LWLAVLKTVI PLLILDRQAV GEWWDQIFFP
110 120 130 140 150
FLNSPTQLKP VFSDLKSILF YILIFHDEDE WGGDLRRECA EETITRLVDL
160 170 180 190 200
YVSKAIENLG DVESQEQRNQ TIECLVNVLV HYGIQRPKEL SSCFCHHFLN
210 220 230 240 250
PPTRIPILSV MVEVIRRQGP RLYEIPQTGF YDLVLKCAEF DTSPILLSYA
260 270 280 290 300
LSFILMILSH ICNSLDDSLY RLFCIYLRFS MIDPTSGFPS STASGNWEVF
310 320 330 340 350
HDFMSTYAST TTSQTDSSYN DVHDIVGSSQ PDYLESLDYS QLFSILYALY
360 370 380 390 400
PINFLEFLRD PKLYASKHNF QIRYSFNQEL LSTKSDGLLG RHLAHSNFLK
410 420 430 440 450
YTAETELTDK SRWTRLDSIA VVALCNSLNA VGIAESVMDP FGGKLPTTYE
460 470 480 490 500
ETSSATGLLA YPNESHDIAS EPFSISWPQN PSISGSVHSA TTFDKAQLSN
510 520 530 540 550
TEDSYDNISH GTSYSEGVSS IHMVKGERGS NNLELTSESL SSTNDTIRRL
560 570 580 590 600
QRDLLFLQNE LRFEKFVRQQ HLQNIGKLHR EHILDMAVES ERQKLLLTNK
610 620 630 640 650
RYKAQIELLN SEIDKHRSES QAALNRRVKW ENDFNNKIKA LREEKKAWKS
660 670 680 690 700
EESELKSSIE SLISQLESIR NSQIDIAFSK NQLELKLQLY ETKLKEYEQH
710 720 730 740 750
LSCVNISKKQ VSSSSDTSFG NTKMDSSMIL SNSEAVSDEQ ERELIESEKH
760 770 780 790 800
RMKLESENLH LQANIELLKK DLEAINVVYE AKIFDLEKRL SSEANAPELH
810 820 830 840 850
NPVNLNYDAQ LSKISEIKEN YDELLTRYRE LEGKFLESQA EVEELKNFQK
860 870 880 890
PLVDTGSSIH SSPGLQQSKF IIRNDSLHPK VGPPRRQSTD TSRSTFRQY
Length:899
Mass (Da):103,435
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03D7E9CC8866ECAB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91078.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S62428

NCBI Reference Sequences

More...
RefSeqi
NP_593028.1, NM_001018427.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC22F3.13.1; SPAC22F3.13.1:pep; SPAC22F3.13

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC22F3.13

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91078.1
PIRiS62428
RefSeqiNP_593028.1, NM_001018427.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KK0X-ray2.90A/B/C/D/E/F/G/H/I/J1-431[»]
4KK1X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-431[»]
SMRiQ09778
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi278359, 89 interactors
IntActiQ09778, 1 interactor
STRINGi4896.SPAC22F3.13.1

PTM databases

iPTMnetiQ09778

Proteomic databases

MaxQBiQ09778
PaxDbiQ09778
PRIDEiQ09778

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2541869

Genome annotation databases

EnsemblFungiiSPAC22F3.13.1; SPAC22F3.13.1:pep; SPAC22F3.13
GeneIDi2541869
KEGGispo:SPAC22F3.13

Organism-specific databases

EuPathDBiFungiDB:SPAC22F3.13
PomBaseiSPAC22F3.13, tsc1

Phylogenomic databases

eggNOGiENOG502R01W, Eukaryota
HOGENOMiCLU_314266_0_0_1
InParanoidiQ09778
OMAiLYPINFM
PhylomeDBiQ09778

Enzyme and pathway databases

ReactomeiR-SPO-165181, Inhibition of TSC complex formation by PKB
R-SPO-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-SPO-5628897, TP53 Regulates Metabolic Genes

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09778

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR007483, Hamartin
PANTHERiPTHR15154, PTHR15154, 1 hit
PfamiView protein in Pfam
PF04388, Hamartin, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSC1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09778
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 12, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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