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Entry version 140 (18 Sep 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Metal-binding regulatory protein cuf1

Gene

cuf1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Copper-sensing transcription factor that regulates iron uptake genes. Under copper starvation conditions activates the transcription of the copper transport genes, ctr4, ctr5 and ctr6.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi11ZincPROSITE-ProRule annotation1
Metal bindingi14ZincPROSITE-ProRule annotation1
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi25ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 40Copper-fistPROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metal-binding regulatory protein cuf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cuf1
ORF Names:SPAC31A2.11c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPAC31A2.11c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC31A2.11c cuf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi13K → A: No nuclear localization. 1 Publication1
Mutagenesisi16R → A: No nuclear localization. 1 Publication1
Mutagenesisi19R → A: No nuclear localization. 1 Publication1
Mutagenesisi24K → A: No nuclear localization. 1 Publication1
Mutagenesisi28R → A: No nuclear localization. 1 Publication1
Mutagenesisi45K → A: No nuclear localization. 1 Publication1
Mutagenesisi47R → A: No nuclear localization. 1 Publication1
Mutagenesisi50R → A: No nuclear localization. 1 Publication1
Mutagenesisi53R → A: No nuclear localization. 1 Publication1
Mutagenesisi328C → A: Constitutive nuclear localization. 1 Publication1
Mutagenesisi330C → A: Constitutive nuclear localization. 1 Publication1
Mutagenesisi334C → A: Constitutive nuclear localization. 1 Publication1
Mutagenesisi336C → A: Constitutive nuclear localization. 1 Publication1
Mutagenesisi339C → A: Constitutive nuclear localization. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949301 – 411Metal-binding regulatory protein cuf1Add BLAST411

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q09728

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09728

PRoteomics IDEntifications database

More...
PRIDEi
Q09728

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
279627, 9 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC31A2.11c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q09728

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09728

Identification of Orthologs from Complete Genome Data

More...
OMAi
MACMKCI

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.430.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001083 Cu_fist_DNA-bd_dom
IPR036395 Cu_fist_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00649 Copper-fist, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00617 COPPERFIST

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01090 Copper-fist, 1 hit
SM00412 Cu_FIST, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57879 SSF57879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01119 COPPER_FIST_1, 1 hit
PS50073 COPPER_FIST_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVINNVKMA CMKCIRGHRS STCKHNDREL FPIRPKGRPI SQCEKCRIAR
60 70 80 90 100
ITRHLHVKCT CNSRKKGSKC STSSTTDLDS SSASNSSCSI PSSISEKLLP
110 120 130 140 150
RDNVKTHCPK RSASCCGKKP DVMPLKINLE SQTDFMGMPL QSQRPHSESY
160 170 180 190 200
RMLPEPEKFK SEYGYPSQFL PIEKLTSNVA YPPNYNNYLK SPYQQPTNFP
210 220 230 240 250
PEIQYNYSHS PQHSIQEAEE AAVYGPPVYR SGYQILYNNN TDSIAAAAAT
260 270 280 290 300
HDLYPQPDVP LTFAMLADGN YVPLPSSTNT YGPSNSYGYE ININESTNHV
310 320 330 340 350
DSSYLPHPIQ LSNYFTLPSS CAQADAACQC GDNCECLGCL THPNNATTLA
360 370 380 390 400
ALNHISALEK ETISHTDLHH TFKHEVNSSN NYELTNDELA ASSPLYTSSS
410
VPPSHITTGS T
Length:411
Mass (Da):45,473
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB18E877B65D5699
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF175404 Genomic DNA Translation: AAD51063.1
AJ243832 Genomic DNA Translation: CAB52304.1
CU329670 Genomic DNA Translation: CAA90469.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38609 S58105

NCBI Reference Sequences

More...
RefSeqi
NP_592923.1, NM_001018324.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC31A2.11c.1; SPAC31A2.11c.1:pep; SPAC31A2.11c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2543198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC31A2.11c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175404 Genomic DNA Translation: AAD51063.1
AJ243832 Genomic DNA Translation: CAB52304.1
CU329670 Genomic DNA Translation: CAA90469.1
PIRiT38609 S58105
RefSeqiNP_592923.1, NM_001018324.2

3D structure databases

SMRiQ09728
ModBaseiSearch...

Protein-protein interaction databases

BioGridi279627, 9 interactors
STRINGi4896.SPAC31A2.11c.1

Proteomic databases

MaxQBiQ09728
PaxDbiQ09728
PRIDEiQ09728

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC31A2.11c.1; SPAC31A2.11c.1:pep; SPAC31A2.11c
GeneIDi2543198
KEGGispo:SPAC31A2.11c

Organism-specific databases

EuPathDBiFungiDB:SPAC31A2.11c
PomBaseiSPAC31A2.11c cuf1

Phylogenomic databases

InParanoidiQ09728
OMAiMACMKCI

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09728

Family and domain databases

Gene3Di3.90.430.10, 1 hit
InterProiView protein in InterPro
IPR001083 Cu_fist_DNA-bd_dom
IPR036395 Cu_fist_DNA-bd_dom_sf
PfamiView protein in Pfam
PF00649 Copper-fist, 1 hit
PRINTSiPR00617 COPPERFIST
SMARTiView protein in SMART
SM01090 Copper-fist, 1 hit
SM00412 Cu_FIST, 1 hit
SUPFAMiSSF57879 SSF57879, 1 hit
PROSITEiView protein in PROSITE
PS01119 COPPER_FIST_1, 1 hit
PS50073 COPPER_FIST_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUF1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09728
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 18, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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