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Entry version 160 (29 Sep 2021)
Sequence version 2 (23 Apr 2003)
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Protein

G protein-coupled receptor kinase 2

Gene

grk-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity).

Required in adult sensory neurons for chemotaxis (PubMed:15157420).

Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations (PubMed:16407969).

Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin (PubMed:28213524).

Acts in head acetylcholine neurons to positively regulate locomotion (PubMed:28968387).

Inactivates dopamine receptor dop-3 which leads to inactivation of guanine nucleotide-binding protein G(o) subunit goa-1 and activation of the unc-77/nca-1 and nca-2 ion channel proteins (PubMed:28968387).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3Required for receptor phosphorylationBy similarity1
Sitei4Required for receptor phosphorylationBy similarity1
Sitei10Required for receptor phosphorylationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei220ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei318Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processChemotaxis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-111933, Calmodulin induced events
R-CEL-416476, G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q09639

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G protein-coupled receptor kinase 2 (EC:2.7.11.16)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:grk-2
ORF Names:W02B3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
W02B3.2 ; CE32946 ; WBGene00001709 ; grk-2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defective egg-laying with mutants retaining 35 eggs compared to 13-14 eggs in wild-type worms (PubMed:28213524, PubMed:28968387). Reduced serotonin levels, increased levels of the serotonin metabolite 5-hydroxyindoleacetic acid, increased levels of amine oxidase amx-2 in early adult stages and reduced levels of phosphorylated amx-2 (PubMed:28213524). Defective locomotion and reduced body length (PubMed:28968387).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3D → K: Failure to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi4L → K: Failure to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi7 – 8VL → AA: Failure to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications2
Mutagenesisi10D → A: Failure to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi106R → A: No effect on ability to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi109Y → I: No effect on ability to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi110D → A: No effect on ability to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi195R → A: Failure to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. 2 Publications1
Mutagenesisi220K → R: Failure to restore avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. Failure to rescue defective egg laying in grk-2 mutants. 2 Publications1
Mutagenesisi354T → I in rt97; dramatic decrease in grk-2 protein levels, defective egg laying, reduced serotonin levels, increased levels of the serotonin metabolite 5-hydroxyindoleacetic acid, increased levels of amine oxidase amx-2 in early adult stages, reduced levels of phosphorylated amx-2, severe defect in octanol avoidance and severely impaired chemotaxis to attractive compounds including 0.1-100 mM NaCl although mutants show avoidance to 25 mM NaCl after pre-exposure to 100 mM NaCl. 3 Publications1
Mutagenesisi379G → E in yak18; decreased body length, slow locomotion and defective egg laying. 1 Publication1
Mutagenesisi567K → E: Failure to restore locomotion in animals lacking endogenous grk-2. Significantly restored avoidance of aversive compounds octanol and quinine in animals lacking endogenous grk-2. Failure to restore avoidance to octanol and quinine in animals lacking endogenous grk-2; when associated with Q-587. 2 Publications1
Mutagenesisi587R → Q: Failure to restore locomotion in animals lacking endogenous grk-2. Reduced ability to restore avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. Failure to restore avoidance to octanol and quinine in animals lacking endogenous grk-2; when associated with E-567. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868411 – 707G protein-coupled receptor kinase 2Add BLAST707

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q09639

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09639

PeptideAtlas

More...
PeptideAtlasi
Q09639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many neurons in the adult including the ASH neurons and other sensory neurons, many interneurons, and motor neurons of the ventral nerve cord (PubMed:15157420). Expressed broadly in head neurons and is detected in several head acetylcholine neurons including the AVA, AVB, AVD and AVE premotor interneurons, the SMD and RMD head motor neurons, and the AIN, AIY, SIA, SIB and SAA interneurons (PubMed:28968387). Expressed in HSN motor neurons and VC4/VC5 motor neurons (PubMed:28213524). Also expressed in vulval muscle cells (PubMed:15157420, PubMed:28213524).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is observed in embryos as early as the 20-30 cell stage and persists throughout development and into adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001709, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with amx-2; the interaction promotes phosphorylation of amx-2.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
40494, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q09639, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.W02B3.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09639

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 175RGSPROSITE-ProRule annotationAdd BLAST122
Domaini191 – 455Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini456 – 523AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST68
Domaini558 – 658PHPROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 190N-terminalAdd BLAST190

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The kinase domain is required for chemotaxis activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0986, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169024

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_63_41_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09639

Identification of Orthologs from Complete Genome Data

More...
OMAi
YGSERDA

Database of Orthologous Groups

More...
OrthoDBi
1104340at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09639

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR000239, GPCR_kinase
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR016137, RGS
IPR036305, RGS_sf
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00717, GPCRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00315, RGS, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097, SSF48097, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADLEAVLAD VSYLMAMEKS RSQPAARASK RIVLPDPSVR SIMQKFLEKS
60 70 80 90 100
GDMKFDKIFN QKLGFLLLKD YAENVSESPC PQIKFYEAIK EYEKMETPDE
110 120 130 140 150
RLTKAREIYD HHIMVEMLAH AHNYSKESLQ HVQYHLLKQN VPPDLFHRYV
160 170 180 190 200
LEICDQLRGD IFQRFLESDK FTRFCQWKNL ELNMQLTMND FSVHRIIGRG
210 220 230 240 250
GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGQ
260 270 280 290 300
DCPFIVCMTY AFQSPDKLCF ILDLMNGGDL HYHLSQHGVF TEQEMIFYAS
310 320 330 340 350
EVILGLEHMH NRFVVYRDLK PANILLDENG HVRVSDLGLA CDYSKKKPHA
360 370 380 390 400
SVGTHGYMAP EVLAKGVAYD SSADWFSLGC MLYKLLKGHS PFRQHKSKDK
410 420 430 440 450
NEIDKMTLTQ DIELPNEGLS KDCRDLLEGL LKRDVPDRLG CRGKGPTEVK
460 470 480 490 500
EHPFFKDVDW QTVYLRRMTP PLIPPRGEVN AADAFDIGNF DDDEVKGVKL
510 520 530 540 550
QDGDSDLYKN FNIVISERWQ NEIAETIFEV VNQDADKAES KKRSKQKIKV
560 570 580 590 600
AVEEKDSDVI VHGYIKKLGG PFTSAWQTKY GKLYPSRLEL YPESLTAKPE
610 620 630 640 650
LVFMDQIEDV CAEMQTIKGE TAIIVKLRDG FKEPKICLTN SDEISLKEWH
660 670 680 690 700
TSLRTAHKVS QELLQRMGRK AIKIYGVNHD PMLSESERPG SVTRAFLNRA

SSVDSGV
Length:707
Mass (Da):80,978
Last modified:April 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD37F03260F324939
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080476 Genomic DNA Translation: CCD63981.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T26096

NCBI Reference Sequences

More...
RefSeqi
NP_497235.2, NM_064834.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W02B3.2.1; W02B3.2.1; WBGene00001709

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W02B3.2

UCSC genome browser

More...
UCSCi
W02B3.2, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080476 Genomic DNA Translation: CCD63981.1
PIRiT26096
RefSeqiNP_497235.2, NM_064834.4

3D structure databases

SMRiQ09639
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi40494, 3 interactors
IntActiQ09639, 2 interactors
STRINGi6239.W02B3.2

Proteomic databases

EPDiQ09639
PaxDbiQ09639
PeptideAtlasiQ09639

Genome annotation databases

EnsemblMetazoaiW02B3.2.1; W02B3.2.1; WBGene00001709
GeneIDi175223
KEGGicel:CELE_W02B3.2
UCSCiW02B3.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175223
WormBaseiW02B3.2 ; CE32946 ; WBGene00001709 ; grk-2

Phylogenomic databases

eggNOGiKOG0986, Eukaryota
GeneTreeiENSGT00940000169024
HOGENOMiCLU_000288_63_41_1
InParanoidiQ09639
OMAiYGSERDA
OrthoDBi1104340at2759
PhylomeDBiQ09639

Enzyme and pathway databases

ReactomeiR-CEL-111933, Calmodulin induced events
R-CEL-416476, G alpha (q) signalling events
SignaLinkiQ09639

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09639

Gene expression databases

BgeeiWBGene00001709, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR000239, GPCR_kinase
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR016137, RGS
IPR036305, RGS_sf
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PF00615, RGS, 1 hit
PRINTSiPR00717, GPCRKINASE
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00315, RGS, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50132, RGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRK2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09639
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 23, 2003
Last modified: September 29, 2021
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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