Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 152 (17 Jun 2020)
Sequence version 4 (21 Sep 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Location of vulva defective 1

Gene

lov-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as pkd-2 and atp-2 in response behavior. May be required for ciliary targeting of pkd-2.6 Publications

Miscellaneous

Worms lacking lov-1 exhibit defects in two aspects of male mating behavior: response to hermaphrodite contact and vulva location.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBehavior

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Location of vulva defective 1
Alternative name(s):
Polycystic kidney disease 1 protein homolog
Polycystin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lov-1
Synonyms:pkd-1
ORF Names:ZK945.9/ZK945.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
ZK945.9 ; CE45696 ; WBGene00003058 ; lov-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2245 – 2265HelicalSequence analysisAdd BLAST21
Transmembranei2453 – 2473HelicalSequence analysisAdd BLAST21
Transmembranei2496 – 2516HelicalSequence analysisAdd BLAST21
Transmembranei2557 – 2577HelicalSequence analysisAdd BLAST21
Transmembranei2592 – 2612HelicalSequence analysisAdd BLAST21
Transmembranei2672 – 2692HelicalSequence analysisAdd BLAST21
Transmembranei2945 – 2965HelicalSequence analysisAdd BLAST21
Transmembranei2994 – 3014HelicalSequence analysisAdd BLAST21
Transmembranei3043 – 3063HelicalSequence analysisAdd BLAST21
Transmembranei3089 – 3109HelicalSequence analysisAdd BLAST21
Transmembranei3144 – 3164HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Cilium, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000006555522 – 3284Location of vulva defective 1Add BLAST3263

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09624

PRoteomics IDEntifications database

More...
PRIDEi
Q09624

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in a subset of three categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons.5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First expressed during L4 and peaks in the adult male.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003058 Expressed in adult organism and 1 other tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PLAT domain) with atp-2 (via N-terminus) and with kin-10 (via C-terminus).

Interacts (via C-terminus) with isoform a of stam-1/pqn-19 (via C-terminus).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
39895, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3887 TRPP complex

Protein interaction database and analysis system

More...
IntActi
Q09624, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZK945.9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2177 – 2226GPSAdd BLAST50
Domaini2288 – 2411PLATPROSITE-ProRule annotationAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 1150Thr-richAdd BLAST931
Compositional biasi253 – 913Ser-richAdd BLAST661

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599 Eukaryota
ENOG410XR4U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164047

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000354_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09624

KEGG Orthology (KO)

More...
KOi
K04985

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDWARES

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752 PLAT_polycystin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000203 GPS
IPR013122 PKD1_2_channel
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723 SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50095 PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q09624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKSNFFVLL LLAISAIQID GLHYQLLDGI ATFRLDNDDT TIGGVPRNSQ
60 70 80 90 100
GVVKIKLSCG LNRLSVENKV TEVSSLELIH NCIQTETRLV GLFLNSTWIT
110 120 130 140 150
LNEVNDDDEI SIAVEAKYEV CYDDGIDRCD GSLWWLQVGG NEMALLGYRE
160 170 180 190 200
KCESGEINEE YARRMCKRPY RSEKSTAISD SQGVYYDGQV LKGVRAKQFS
210 220 230 240 250
MRTSGSPTLR RMKRDAGDNT CDYTIESTST STTTPTTTTV TSTVTSTTTV
260 270 280 290 300
PTSTSTVTTA MSTSTSTPST STTIESTSTT FTSTASTSTS STSTTQQSSS
310 320 330 340 350
TITSSPSSTT LSTSIPTTTT PEITSTLSSL PDNAICSYLD ETTTSTTFTT
360 370 380 390 400
TMLTSTTTEE PSTSTTTTEV TSTSSTVTTT EPTTTLTTST ASTSTTEPST
410 420 430 440 450
STVTTSPSTS PVTSTVTSSS SSSTTVTTPT STESTSTSPS STVTTSTTAP
460 470 480 490 500
STSTTGPSSS SSTPSSTASS SVSSTASSTQ SSTSTQQSST TTKSETTTSS
510 520 530 540 550
DGTNPDFYFV EKATTTFYDS TSVNLTLNSG LGIIGYQTSI ECTSPTSSNY
560 570 580 590 600
VSTTKDGACF TKSVSMPRLG GTYPASTFVG PGNYTFRATM TTDDKKVYYT
610 620 630 640 650
YANVYIQEYS STTIESESST SAVASSTSST PSTPSSTLST STVTEPSSTR
660 670 680 690 700
SSDSTTTSAG STTTLQESTT TSEESTTDSS TTTISDTSTT SSSPSSTTAD
710 720 730 740 750
STSTLSVDQF DFILDSGLSW NETRHNEDSI NIVPLPTNAI TPTERSQTFE
760 770 780 790 800
CRNVSTEPFL IIKESTCLNY SNTVLNATYS SNIPIQPIET FLVGIGTYEF
810 820 830 840 850
RINMTDLTTM QVVSHIFTLN VVADSTSTSE VTSTTSTGSS SESSAISTTS
860 870 880 890 900
GIESTSTLEA STTDASQDSS TSTSDSGTTS DSTTIDSSNS TPSTSDSSGL
910 920 930 940 950
SQTPSDSSSA SDSMRTTTVD PDASTETPYD FVLENLTWNE TVYYSENPFY
960 970 980 990 1000
ITPIPNKEPG ALTTAMTCQC RNDSSQPFVL LKESNCLTEF GKNGAYSASV
1010 1020 1030 1040 1050
SFNPMTSFVP ATGTYEFLIN VTNRASGESA SHIFTMNVVL PTTTTETPPT
1060 1070 1080 1090 1100
TVSSSDDAGG KTGGTGATGG TGGTGSGGSA TTLSTGDAVR STTSGSGSGQ
1110 1120 1130 1140 1150
SSTGSGAGGS GTTASGSGSG GSSGTGSDGV NSGKTTALNG DGTGSGTATT
1160 1170 1180 1190 1200
PGSHLGDGGS TSGSGSDSNG SSGVSTKSSS GSDTSGSSDS SGANGAFSAT
1210 1220 1230 1240 1250
AQPSTRTTKT RSSLATVSPI SAAEQAIIDA QKADVMNQLA GIMDGSASNN
1260 1270 1280 1290 1300
SLNTSSSLLN QISSLPAADL VEVAQSLLSN TLKIPGVGNM SSVDVLKTLQ
1310 1320 1330 1340 1350
DNIATTNSEL ADEMAKVITK LANVNMTSAQ SLNSVLSSLD LALKGSTVYT
1360 1370 1380 1390 1400
LGVSSTKSKD GTYAVIFGYV IASGYTLVSP RCTLSIYGST IYLTGDTRAS
1410 1420 1430 1440 1450
YKQLDGDTVT ADTMLAAAIG IQGMFATNGR TVQVEQDKID DKRSLVSGNI
1460 1470 1480 1490 1500
MATMSGVGDV QSGEYSYNDM YVTAWNVTYD NSTVGSTSQK NTSFSFNIPV
1510 1520 1530 1540 1550
SEVQYILLIE SGTMIKLHST QNIVSRGLVV TASYGGVTYT ITCTNGTGKF
1560 1570 1580 1590 1600
VEVDTDNAIF SYNADSFTVV ASDGSSASTV KKLIQMPIVI ENVNLALFNQ
1610 1620 1630 1640 1650
TTSPLVFSNA GSYSMRMVLS PQDIGIPAVS ALSQTVSIST LSPTASYTKD
1660 1670 1680 1690 1700
DLQSLIKEQT LVTVSGTLFF SKASSIDVSG YSFFVDSTAL YLSNSVTTLV
1710 1720 1730 1740 1750
ISSPTYNIVS LALGGYGIQI TAGTYTSGSQ THTVTLMEFS DTQKMRIDGG
1760 1770 1780 1790 1800
LIIRNGTNGY VIQNGQVSTE GDVSGTKIDI VPQSLMNQES QQQIETILSN
1810 1820 1830 1840 1850
TQDFLTNNGM TMTDAEINDT SNSLLSIAGS LTSALKIALD NPLSSDLAAN
1860 1870 1880 1890 1900
LKYATDNYDS LYNVLPSDPD NIVYVEEMTS EEWAAYVTKM FQKNIAKNLA
1910 1920 1930 1940 1950
NQLASTLDTL ENTLAARAIA TGNLPYDYSN SVDGTGMVIV IDDASNIVGK
1960 1970 1980 1990 2000
TQNCEEWAFK LPSPASTLNT AEITDKTLIQ VGLVCYATNP RTYVDNFDML
2010 2020 2030 2040 2050
ITSGALEAHI KDENQIIIPI TGTTAPIYVN GRGSEDDAVL TLMQQGDFAS
2060 2070 2080 2090 2100
YQILDLHAFR TTNWNNSLQV EIIASQDYEI PNNDDTYMFS SFQSLPGPLE
2110 2120 2130 2140 2150
SNHEWIFDLN TLNKTSNYFV TAGNLINNTG LFFIGIGKRN SSTNTGNSSD
2160 2170 2180 2190 2200
IVNYGQYDSM QWSFARSVPM DYQVAAVSKG CYFYQKTSDV FNSEGMYPSD
2210 2220 2230 2240 2250
GQGMQFVNCS TDHLTMFSVG AFNPTIDADF SYNYNVNEIE KNVKVMIAAV
2260 2270 2280 2290 2300
FMLVVYGCLT INAIICQRKD ASRGRLRFLK DNEPHDGYMY VIAVETGYRM
2310 2320 2330 2340 2350
FATTDSTICF NLSGNEGDQI FRSFRSEEDG NWEFPFSWGT TDRFVMTTAF
2360 2370 2380 2390 2400
PLGELEYMRL WLDDAGLDHR ESWYCNRIIV KDLQTQDIYY FPFNNWLGTK
2410 2420 2430 2440 2450
NGDGETERLA RVEYKRRFLD ESMSMHMLAQ TISWFAMFTG GGNRLRDRVS
2460 2470 2480 2490 2500
RQDYSVSIIF SLVVVSMISI TILKSDNSII SDSKSVSEFT FTIKDIAFGV
2510 2520 2530 2540 2550
GFGVLITFLN SLHILLCTKC RSHSEHYYYK KRKREDPEFK DNSGSWPMFM
2560 2570 2580 2590 2600
AGMARTIIVF PVLMGLIYIS GAGMSLMDDL ANSFYIRFLI SLILWAVVFE
2610 2620 2630 2640 2650
PIKGLIWAFL ILKTRKSHKI INKLEEALLR AKPAETFLRN PYGKIEKGLG
2660 2670 2680 2690 2700
TEIADVTKLR DTENRKMRDE QLFITIRDML CFFASLYIMV MLTYYCKDRH
2710 2720 2730 2740 2750
GYWYQLEMST ILNINQKNYG DNTFMSIQHA DDFWDWARES LATALLASWY
2760 2770 2780 2790 2800
DGNPAYGMRA YMNDKVSRSM GIGTIRQVRT KKSAECTMFK QFQGYINDCG
2810 2820 2830 2840 2850
EELTSKNEEK TLYMQAGWTE LESENGTDAS DEYTYKTSEE LSTETVSGLL
2860 2870 2880 2890 2900
YSYSGGGYTI SMSGTQAEII TLFNKLDSER WIDDHTRAVI IEFSAYNAQI
2910 2920 2930 2940 2950
NYFSVVQLLV EIPKSGIYLP NSWVESVRLI KSEGSDGTVV KYYEMLYIFF
2960 2970 2980 2990 3000
SVLIFVKEIV FYLYGRYKVI TTMKPTRNPF KIVYQLALGN FSPWNFMDLI
3010 3020 3030 3040 3050
VGALAVASVL AYTIRQRTTN RAMEDFNANN GNSYINLTEQ RNWEIVFSYC
3060 3070 3080 3090 3100
LAGAVFFTSC KMIRILRFNR RIGVLAATLD NALGAIVSFG IAFLFFSMTF
3110 3120 3130 3140 3150
NSVLYAVLGN KMGGYRSLMA TFQTALAGML GKLDVTSIQP ISQFAFVVIM
3160 3170 3180 3190 3200
LYMIAGSKLV LQLYVTIIMF EFEEIRNDSE KQTNDYEIID HIKYKTKRRL
3210 3220 3230 3240 3250
GLLEPKDFAP VSIADTQKDF RLFHSAVAKV NLLHHRATRM LQTQGQYQNQ
3260 3270 3280
TVINYTLSYD PVSAIHETGP KRFQKWRLND VEKD
Length:3,284
Mass (Da):355,492
Last modified:September 21, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E2E5320857CED2F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48544, Z48582 Genomic DNA Translation: CAB70192.3

Protein sequence database of the Protein Information Resource

More...
PIRi
T28125

NCBI Reference Sequences

More...
RefSeqi
NP_496184.3, NM_063783.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK945.9.1; ZK945.9.1; WBGene00003058

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK945.9

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48544, Z48582 Genomic DNA Translation: CAB70192.3
PIRiT28125
RefSeqiNP_496184.3, NM_063783.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi39895, 1 interactor
ComplexPortaliCPX-3887 TRPP complex
IntActiQ09624, 3 interactors
STRINGi6239.ZK945.9

Proteomic databases

PaxDbiQ09624
PRIDEiQ09624

Genome annotation databases

EnsemblMetazoaiZK945.9.1; ZK945.9.1; WBGene00003058
GeneIDi174576
KEGGicel:CELE_ZK945.9

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174576
WormBaseiZK945.9 ; CE45696 ; WBGene00003058 ; lov-1

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XR4U LUCA
GeneTreeiENSGT00940000164047
HOGENOMiCLU_000354_0_0_1
InParanoidiQ09624
KOiK04985
OMAiWDWARES
OrthoDBi1276906at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09624

Gene expression databases

BgeeiWBGene00003058 Expressed in adult organism and 1 other tissue

Family and domain databases

CDDicd01752 PLAT_polycystin, 1 hit
InterProiView protein in InterPro
IPR000203 GPS
IPR013122 PKD1_2_channel
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
PfamiView protein in Pfam
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50095 PLAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKD1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09624
Secondary accession number(s): Q09625, Q969D4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 21, 2011
Last modified: June 17, 2020
This is version 152 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again