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Protein

Homeobox protein vab-15

Gene

vab-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • embryonic morphogenesis Source: UniProtKB
  • locomotory behavior Source: UniProtKB
  • parturition Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein vab-15
Alternative name(s):
Variable abnormal morphology protein 15
Gene namesi
Name:vab-15
ORF Names:R07B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiR07B1.1 ; CE01626 ; WBGene00006881 ; vab-15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit the absence of AVM, PVM, and PLM touch cells, defective egg laying, embryonic or larval lethality, cell degeneration, malformation of the posterior body, and uncoordinated movement.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493501 – 225Homeobox protein vab-15Add BLAST225

Proteomic databases

PaxDbiQ09604

Expressioni

Tissue specificityi

Expressed in the ectodermal cells of embryos and seam cells and ventral cord motor neurons of young larvae.1 Publication

Developmental stagei

Expressed from the twofold embryo stage through to L4 larval stage.1 Publication

Gene expression databases

BgeeiWBGene00006881

Interactioni

Protein-protein interaction databases

IntActiQ09604, 2 interactors
STRINGi6239.R07B1.1

Structurei

3D structure databases

ProteinModelPortaliQ09604
SMRiQ09604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
InParanoidiQ09604
KOiK09341
OMAiDPVMIYF
OrthoDBiEOG091G0P1V
PhylomeDBiQ09604

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q09604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSKDEKPKQ SGLFSVESLL ETPKQKCRED LPKPTPITPK TPMLIPGLHP
60 70 80 90 100
MTPYFGAQLD PVMIYFAQTG NRLPIVSSDS SPESCASSPL SMQHSLQWLS
110 120 130 140 150
SQREDSPTSD DAKIQIGLSK CMLRKHKNNR KPRTPFSTQQ LISLERKFQS
160 170 180 190 200
KQYLSIAERA EFSASLQLTE TQVKIWFQNR RAKSKRLQEA EVEKVKFAQA
210 220
SAYAAAAVGG APDPSSILAF YQPQW
Length:225
Mass (Da):25,228
Last modified:November 1, 1995 - v1
Checksum:iE7C920E9E1B9AC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286218 mRNA Translation: AAF88063.1
Z48621 Genomic DNA Translation: CAA88539.1
PIRiT23992
RefSeqiNP_509648.1, NM_077247.5
UniGeneiCel.19372

Genome annotation databases

EnsemblMetazoaiR07B1.1; R07B1.1; WBGene00006881
GeneIDi181197
KEGGicel:CELE_R07B1.1
UCSCiR07B1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiVAB15_CAEEL
AccessioniPrimary (citable) accession number: Q09604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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