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Entry version 126 (02 Jun 2021)
Sequence version 2 (21 Feb 2001)
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Protein

Cystinosin homolog

Gene

ctns-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cystine/H+ symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (By similarity).

May play a role in the degradation of engulfed apoptotic cells (PubMed:18351800).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-425393, Transport of inorganic cations/anions and amino acids/oligopeptides
R-CEL-5223345, Miscellaneous transport and binding events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cystinosin homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ctns-1
ORF Names:C41C4.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C41C4.7a ; CE28541 ; WBGene00008052 ; ctns-1
C41C4.7b ; CE32325 ; WBGene00008052 ; ctns-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 123LumenalSequence analysisAdd BLAST104
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 207LumenalSequence analysisAdd BLAST23
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 238CytoplasmicSequence analysis10
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 263LumenalSequence analysis4
Transmembranei264 – 285HelicalSequence analysisAdd BLAST22
Topological domaini286 – 295CytoplasmicSequence analysis10
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 337LumenalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 404CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002055161 – 404Cystinosin homologAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q09500

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09500

PeptideAtlas

More...
PeptideAtlasi
Q09500

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008052, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q09500, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.C41C4.7a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 191PQ-loop 1Add BLAST67
Domaini266 – 327PQ-loop 2Add BLAST62

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cystinosin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3145, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005338

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09500

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLGFVCY

Database of Orthologous Groups

More...
OrthoDBi
1138417at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09500

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005282, LC_transporter
IPR006603, PQ-loop_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR13131, PTHR13131, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04193, PQ-loop, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00679, CTNS, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00951, 2A43, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q09500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFPVAFLLV LFLVPFTFAT NNLVVRQKEL EIVIGGEVSV NFQIKNHTSQ
60 70 80 90 100
SLNATRISLS QSPYISHPDA ILVDNWNANV TVLGSQLVSG AILEALNCTT
110 120 130 140 150
DGSITCPLDL EDAFARITVI RSHFLAILIQ IVGWTYFFAW SISFYPQMYL
160 170 180 190 200
NFKRKSVVGL NFDFLSLNLV GFCAYAIFNL LMYYNSHVKN EYNIVNPRSP
210 220 230 240 250
PPVLLNDVVF AVHAFLACFI TILQCLFYER DNQSVSSKCI ALMIVLISFG
260 270 280 290 300
FCSAAATVLR KIQLLSFVTS LSYIKMAVTC CKYFPQAYFN YTRKSTVGWS
310 320 330 340 350
IGNIMLDFTG GTLDILQMIL QAVNVNDWSA FYANPVKFGL GFVSIFFDII
360 370 380 390 400
FMVQHYVLYP NAEVPHNEYH GVDNPNPDNI ARDAEQYAGD SESMESTEPI

IVHD
Length:404
Mass (Da):45,394
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEF8AEA512475433
GO
Isoform b (identifier: Q09500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-374: VPHNEYHGVDN → EPKKNQETSRF
     375-404: Missing.

Show »
Length:374
Mass (Da):42,194
Checksum:iBB8FAE4D84811170
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035818364 – 374VPHNEYHGVDN → EPKKNQETSRF in isoform b. CuratedAdd BLAST11
Alternative sequenceiVSP_035819375 – 404Missing in isoform b. CuratedAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48045 Genomic DNA Translation: CAA88102.2
Z48045 Genomic DNA Translation: CAD56564.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19875

NCBI Reference Sequences

More...
RefSeqi
NP_495704.1, NM_063303.4 [Q09500-1]
NP_872022.1, NM_182222.4 [Q09500-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C41C4.7a.1; C41C4.7a.1; WBGene00008052 [Q09500-1]
C41C4.7b.1; C41C4.7b.1; WBGene00008052 [Q09500-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174308

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C41C4.7

UCSC genome browser

More...
UCSCi
C41C4.7a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48045 Genomic DNA Translation: CAA88102.2
Z48045 Genomic DNA Translation: CAD56564.1
PIRiT19875
RefSeqiNP_495704.1, NM_063303.4 [Q09500-1]
NP_872022.1, NM_182222.4 [Q09500-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ09500, 1 interactor
STRINGi6239.C41C4.7a

Proteomic databases

EPDiQ09500
PaxDbiQ09500
PeptideAtlasiQ09500

Genome annotation databases

EnsemblMetazoaiC41C4.7a.1; C41C4.7a.1; WBGene00008052 [Q09500-1]
C41C4.7b.1; C41C4.7b.1; WBGene00008052 [Q09500-2]
GeneIDi174308
KEGGicel:CELE_C41C4.7
UCSCiC41C4.7a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174308
WormBaseiC41C4.7a ; CE28541 ; WBGene00008052 ; ctns-1
C41C4.7b ; CE32325 ; WBGene00008052 ; ctns-1

Phylogenomic databases

eggNOGiKOG3145, Eukaryota
GeneTreeiENSGT00390000005338
InParanoidiQ09500
OMAiVLGFVCY
OrthoDBi1138417at2759
PhylomeDBiQ09500

Enzyme and pathway databases

ReactomeiR-CEL-425393, Transport of inorganic cations/anions and amino acids/oligopeptides
R-CEL-5223345, Miscellaneous transport and binding events

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09500

Gene expression databases

BgeeiWBGene00008052, Expressed in adult organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR005282, LC_transporter
IPR006603, PQ-loop_rpt
PANTHERiPTHR13131, PTHR13131, 1 hit
PfamiView protein in Pfam
PF04193, PQ-loop, 2 hits
SMARTiView protein in SMART
SM00679, CTNS, 2 hits
TIGRFAMsiTIGR00951, 2A43, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTNS_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09500
Secondary accession number(s): Q8I4M4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: June 2, 2021
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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