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Entry version 120 (11 Dec 2019)
Sequence version 2 (30 May 2000)
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Protein

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Gene

dph-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5358493 Synthesis of diphthamide-EEF2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2Curated (EC:2.5.1.108By similarity)
Alternative name(s):
Diphthamide biosynthesis protein 2
Diphtheria toxin resistance protein 2Curated
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dph-2
ORF Names:C09G5.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C09G5.2a ; CE15608 ; WBGene00007488 ; dph-2
C09G5.2b ; CE45960 ; WBGene00007488 ; dph-2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000833951 – 4762-(3-amino-3-carboxypropyl)histidine synthase subunit 2Add BLAST476

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q09454

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09454

PeptideAtlas

More...
PeptideAtlasi
Q09454

PRoteomics IDEntifications database

More...
PRIDEi
Q09454

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007488 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
39963, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q09454, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.C09G5.2a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09454

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2648 Eukaryota
COG1736 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016777

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09454

KEGG Orthology (KO)

More...
KOi
K17866

Identification of Orthologs from Complete Genome Data

More...
OMAi
VELAFCE

Database of Orthologous Groups

More...
OrthoDBi
750182at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09454

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11840, 1 hit
3.40.50.11850, 1 hit
3.40.50.11860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010014 DHP2
IPR016435 DPH1/DPH2
IPR042263 DPH1/DPH2_1
IPR042264 DPH1/DPH2_2
IPR042265 DPH1/DPH2_3

The PANTHER Classification System

More...
PANTHERi
PTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01866 Diphthamide_syn, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q09454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTESAPSAFF TTSTPADHVH EEESSNTGYF ENLPENDIHS FFEIDATSEW
60 70 80 90 100
IKQGNHQRIA LQFPDSLLPY SEKVTKLIES RFRSESAKKT FVLADTSYRS
110 120 130 140 150
CCVDEVAAAH ADCTALVHFG EACHSAPTDK IDVKYVLGSM PIFIDQFRME
160 170 180 190 200
FQNVADQLTA EHIVLLMDSC FSHEQEKVAA VIKEVLPGNR HVECSLLPSE
210 220 230 240 250
DVLKQNRQNI YLGREIPSCL RNNQPTDLIF CGFPNSPLLP IWLLSYPSCS
260 270 280 290 300
TVSHFNPINK TIQHESTRSS RLLRKRLFLV EKLKDADTVG LVVGSVGVDK
310 320 330 340 350
HREAVKRMRE MCKKAGKKIY VISVGKINVP KLSNFSTDID VFVLLSCPFG
360 370 380 390 400
VVLDSSDYFR PVVSYFEAEI ALNPAKTWAA DFGWSAEFAA FLEDKIETEV
410 420 430 440 450
PDDKAAGDFS LISGKVRVQK TEEEKNGDGP SSVAIYNPGY CNDRTWKGLN
460 470
DGVSTAEDST KMGEGRSGIA QGYSGK
Length:476
Mass (Da):52,955
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCC54BBA611E10D9
GO
Isoform b (identifier: Q09454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.

Show »
Length:169
Mass (Da):18,388
Checksum:i64AADABA52DE344D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0440381 – 307Missing in isoform b. CuratedAdd BLAST307

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z46791 Genomic DNA Translation: CAA86761.1
Z46791 Genomic DNA Translation: CCA65532.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19146

NCBI Reference Sequences

More...
RefSeqi
NP_001254257.1, NM_001267328.1 [Q09454-1]
NP_001254258.1, NM_001267329.1 [Q09454-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C09G5.2a.1; C09G5.2a.1; WBGene00007488 [Q09454-1]
C09G5.2b.1; C09G5.2b.1; WBGene00007488 [Q09454-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C09G5.2

UCSC genome browser

More...
UCSCi
C09G5.2 c. elegans [Q09454-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46791 Genomic DNA Translation: CAA86761.1
Z46791 Genomic DNA Translation: CCA65532.1
PIRiT19146
RefSeqiNP_001254257.1, NM_001267328.1 [Q09454-1]
NP_001254258.1, NM_001267329.1 [Q09454-2]

3D structure databases

SMRiQ09454
ModBaseiSearch...

Protein-protein interaction databases

BioGridi39963, 5 interactors
IntActiQ09454, 1 interactor
STRINGi6239.C09G5.2a

Proteomic databases

EPDiQ09454
PaxDbiQ09454
PeptideAtlasiQ09454
PRIDEiQ09454

Genome annotation databases

EnsemblMetazoaiC09G5.2a.1; C09G5.2a.1; WBGene00007488 [Q09454-1]
C09G5.2b.1; C09G5.2b.1; WBGene00007488 [Q09454-2]
GeneIDi174649
KEGGicel:CELE_C09G5.2
UCSCiC09G5.2 c. elegans [Q09454-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174649
WormBaseiC09G5.2a ; CE15608 ; WBGene00007488 ; dph-2
C09G5.2b ; CE45960 ; WBGene00007488 ; dph-2

Phylogenomic databases

eggNOGiKOG2648 Eukaryota
COG1736 LUCA
GeneTreeiENSGT00940000153694
HOGENOMiHOG000016777
InParanoidiQ09454
KOiK17866
OMAiVELAFCE
OrthoDBi750182at2759
PhylomeDBiQ09454

Enzyme and pathway databases

UniPathwayiUPA00559
ReactomeiR-CEL-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09454

Gene expression databases

BgeeiWBGene00007488 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.40.50.11840, 1 hit
3.40.50.11850, 1 hit
3.40.50.11860, 1 hit
InterProiView protein in InterPro
IPR010014 DHP2
IPR016435 DPH1/DPH2
IPR042263 DPH1/DPH2_1
IPR042264 DPH1/DPH2_2
IPR042265 DPH1/DPH2_3
PANTHERiPTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit
PfamiView protein in Pfam
PF01866 Diphthamide_syn, 1 hit
SFLDiSFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit
TIGRFAMsiTIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPH2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09454
Secondary accession number(s): F5GU80
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: December 11, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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