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Entry version 119 (08 May 2019)
Sequence version 2 (06 Jun 2002)
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Protein

DnaJ homolog dnj-5

Gene

dnj-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DnaJ homolog dnj-5
Alternative name(s):
DnaJ domain protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnj-5
ORF Names:C04A2.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C04A2.7a ; CE29657 ; WBGene00001023 ; dnj-5
C04A2.7b ; CE29658 ; WBGene00001023 ; dnj-5
C04A2.7c ; CE29659 ; WBGene00001023 ; dnj-5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000711351 – 915DnaJ homolog dnj-5Add BLAST915

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09446

PeptideAtlas

More...
PeptideAtlasi
Q09446

PRoteomics IDEntifications database

More...
PRIDEi
Q09446

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001023 Expressed in 5 organ(s), highest expression level in adult organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q09446 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C04A2.7a.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini660 – 724JPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 70Poly-Pro6
Compositional biasi137 – 164His-richAdd BLAST28

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0720 Eukaryota
ENOG410Z2TP LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019371

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09446

KEGG Orthology (KO)

More...
KOi
K09534

Identification of Orthologs from Complete Genome Data

More...
OMAi
EKHFLGN

Database of Orthologous Groups

More...
OrthoDBi
580949at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257 DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR032843 Jiv

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226 DnaJ, 1 hit
PF14901 Jiv90, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00271 DnaJ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50076 DNAJ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q09446-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSFDDPEKH FLGNLLEDDP GSSVTSATSP FAGINGSTST ALTSQVPTVG
60 70 80 90 100
PVMCPTELSM SNAWPEPPPP YSPRHESWGL PSNANTTLLG SSSLTSSNWF
110 120 130 140 150
PFTDQKETSS NEILSSLNLA AGSSSPALPS TPSRVPHHPS SQVHHFHHNL
160 170 180 190 200
HHHTHTHNVQ VQNHYFGAPP PGLESFGPTR TSSTSSSQIY DAIPNPSWNY
210 220 230 240 250
TGLSNINADS NVLFSDWKNK NSSQTSPVST VVSESSISSN LETRPVHPPL
260 270 280 290 300
SPSEVVEIAK EKKNVSKSYA EHLSKSTAGT QKKGAPIGAE KKQKQELAKK
310 320 330 340 350
MSNQLPIESI ATRIVVKGQP HSAPVVSRMP FSYRDVAARS DHTSSSNHPN
360 370 380 390 400
HQPDELQRKE LSSADLKLND SKAVRTKNND HRETGKTRNT IDPTDFNKKN
410 420 430 440 450
RVDNEFQKIN NRKNKKEKAV TEVAAPVIFE GVHPVDSSSR YDVLKNLESP
460 470 480 490 500
NQSYHEKKSA NGRPPLIQKI FSRSSSPADD IIDTEEEDPH RVRSSSTHVH
510 520 530 540 550
QNGNGQVKKD QRKRVAQVNQ RRRKGRKEEP SWLQNAFSTF VDVLFFVWGY
560 570 580 590 600
ACFGLQWTLL LIVEVCQKIA DIFVTFGKSL WAGTCKGLRN VILAFVYLCF
610 620 630 640 650
FVVFAIKSVV VRLLTFINMI GAEESDETVE EQDWGCKKEI PIATNATEFA
660 670 680 690 700
DRLSRETIRD AYSVFGLRSD CSDDDIKRNY KRLAALVSPD KCTIDAADQV
710 720 730 740 750
YELVDVAFSA IGYKDSRSEY TLENLKNNEV HEQLISVWND MTKAVEEARN
760 770 780 790 800
TIFCDCENTH FRVATSISPS QARSCKRCGV KHPAKQNDIW VEKRHLGLTS
810 820 830 840 850
TYYTCTDNVV YDITSWATCK SQRAMLKNMR AHTHNVQYRL LSPMFKNSDF
860 870 880 890 900
DAQSQYYNSS YPSSSTDARF LSDLQEEYST LLRQRSLAQI SFKNCEPREE
910
DRSRRAANRR QKRWR
Length:915
Mass (Da):102,740
Last modified:June 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B38BD98DC4133C1
GO
Isoform B (identifier: Q09446-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-849: SQRAMLKNMRAHTHNVQYRLLSPMFKNSD → KNKKAELISNDGCRWTKEHQINKRRYPTK
     850-915: Missing.

Show »
Length:849
Mass (Da):94,844
Checksum:i2624393C586FC73D
GO
Isoform C (identifier: Q09446-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: Missing.
     845-846: Missing.

Show »
Length:912
Mass (Da):102,336
Checksum:iA9C6F3A57E3EF077
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8MQF1Q8MQF1_CAEEL
DnaJ homolog dnj-5
dnj-5 C04A2.7, CELE_C04A2.7
868Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001298160Missing in isoform C. Curated1
Alternative sequenceiVSP_001299821 – 849SQRAM…FKNSD → KNKKAELISNDGCRWTKEHQ INKRRYPTK in isoform B. CuratedAdd BLAST29
Alternative sequenceiVSP_001300845 – 846Missing in isoform C. Curated2
Alternative sequenceiVSP_001301850 – 915Missing in isoform B. CuratedAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080320 Genomic DNA Translation: CCD62846.1
FO080320 Genomic DNA Translation: CCD62847.1
FO080320 Genomic DNA Translation: CCD62848.1

NCBI Reference Sequences

More...
RefSeqi
NP_495400.2, NM_062999.6 [Q09446-1]
NP_495401.2, NM_063000.6 [Q09446-2]
NP_741015.1, NM_171014.4 [Q09446-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C04A2.7a.1; C04A2.7a.1; WBGene00001023 [Q09446-1]
C04A2.7a.2; C04A2.7a.2; WBGene00001023 [Q09446-1]
C04A2.7b.1; C04A2.7b.1; WBGene00001023 [Q09446-2]
C04A2.7b.2; C04A2.7b.2; WBGene00001023 [Q09446-2]
C04A2.7c.1; C04A2.7c.1; WBGene00001023 [Q09446-3]
C04A2.7c.2; C04A2.7c.2; WBGene00001023 [Q09446-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C04A2.7

UCSC genome browser

More...
UCSCi
C04A2.7a c. elegans [Q09446-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080320 Genomic DNA Translation: CCD62846.1
FO080320 Genomic DNA Translation: CCD62847.1
FO080320 Genomic DNA Translation: CCD62848.1
RefSeqiNP_495400.2, NM_062999.6 [Q09446-1]
NP_495401.2, NM_063000.6 [Q09446-2]
NP_741015.1, NM_171014.4 [Q09446-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C04A2.7a.1

Proteomic databases

PaxDbiQ09446
PeptideAtlasiQ09446
PRIDEiQ09446

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC04A2.7a.1; C04A2.7a.1; WBGene00001023 [Q09446-1]
C04A2.7a.2; C04A2.7a.2; WBGene00001023 [Q09446-1]
C04A2.7b.1; C04A2.7b.1; WBGene00001023 [Q09446-2]
C04A2.7b.2; C04A2.7b.2; WBGene00001023 [Q09446-2]
C04A2.7c.1; C04A2.7c.1; WBGene00001023 [Q09446-3]
C04A2.7c.2; C04A2.7c.2; WBGene00001023 [Q09446-3]
GeneIDi174122
KEGGicel:CELE_C04A2.7
UCSCiC04A2.7a c. elegans [Q09446-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174122
WormBaseiC04A2.7a ; CE29657 ; WBGene00001023 ; dnj-5
C04A2.7b ; CE29658 ; WBGene00001023 ; dnj-5
C04A2.7c ; CE29659 ; WBGene00001023 ; dnj-5

Phylogenomic databases

eggNOGiKOG0720 Eukaryota
ENOG410Z2TP LUCA
HOGENOMiHOG000019371
InParanoidiQ09446
KOiK09534
OMAiEKHFLGN
OrthoDBi580949at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09446

Gene expression databases

BgeeiWBGene00001023 Expressed in 5 organ(s), highest expression level in adult organism
ExpressionAtlasiQ09446 baseline and differential

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR032843 Jiv
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF14901 Jiv90, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNJ5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09446
Secondary accession number(s): Q95QY2, Q95QY3, Q95QY4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: May 8, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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