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Protein

Probable ubiquitin carboxyl-terminal hydrolase ubh-4

Gene

ubh-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83NucleophileBy similarity1
Active sitei158Proton donorBy similarity1
Sitei173Important for enzyme activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-CEL-5689603 UCH proteinases

Protein family/group databases

MEROPSiC12.005

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase ubh-4 (EC:3.4.19.12)
Alternative name(s):
Ubiquitin C-terminal hydrolase family 1 member 4
Ubiquitin thioesterase 4
Gene namesi
Name:ubh-4
ORF Names:C08B11.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC08B11.7 ; CE36913 ; WBGene00006724 ; ubh-4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110711 – 321Probable ubiquitin carboxyl-terminal hydrolase ubh-4Add BLAST321

Proteomic databases

EPDiQ09444
PaxDbiQ09444
PeptideAtlasiQ09444
PRIDEiQ09444

Expressioni

Gene expression databases

BgeeiWBGene00006724

Interactioni

Protein-protein interaction databases

BioGridi39621, 1 interactor
DIPiDIP-26660N
IntActiQ09444, 1 interactor
STRINGi6239.C08B11.7

Structurei

3D structure databases

ProteinModelPortaliQ09444
SMRiQ09444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.Curated

Phylogenomic databases

eggNOGiKOG2778 Eukaryota
ENOG410XP0P LUCA
GeneTreeiENSGT00510000046560
HOGENOMiHOG000203918
InParanoidiQ09444
KOiK05610
OMAiTIQNACA
OrthoDBiEOG091G0EO2
PhylomeDBiQ09444

Family and domain databases

Gene3Di3.40.532.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
IPR017390 Ubiquitinyl_hydrolase_UCH37
PANTHERiPTHR10589 PTHR10589, 1 hit
PfamiView protein in Pfam
PF01088 Peptidase_C12, 1 hit
PIRSFiPIRSF038120 Ubiquitinyl_hydrolase_UCH37, 1 hit
PRINTSiPR00707 UBCTHYDRLASE
SUPFAMiSSF54001 SSF54001, 1 hit

Sequencei

Sequence statusi: Complete.

Q09444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAGSWCLI ESDPGVFTEM LRGFGVDGLQ VEELYSLDDD KAMTRPTYGL
60 70 80 90 100
IFLFKWRQGD ETTGIPSDKQ NIFFAHQTIQ NACATQALIN LLMNVEDTDV
110 120 130 140 150
KLGNILNQYK EFAIDLDPNT RGHCLSNSEE IRTVHNSFSR QTLFELDIKG
160 170 180 190 200
GESEDNYHFV TYVPIGNKVY ELDGLRELPL EVAEFQKEQD WIEAIKPVIQ
210 220 230 240 250
QRMQKYSEGE ITFNLMALVP NRKQKLQEMM ENLIQANENN ELEEQIADLN
260 270 280 290 300
KAIADEDYKM EMYRKENNRR RHNYTPFVIE LMKILAKEGK LVGLVDNAYQ
310 320
AAKEKSKLNT DITKLELKRK Q
Length:321
Mass (Da):37,120
Last modified:December 21, 2004 - v2
Checksum:iF6A658161FC13AD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46676 Genomic DNA Translation: CAA86665.2
PIRiT19070
RefSeqiNP_495684.2, NM_063283.4
UniGeneiCel.15951

Genome annotation databases

EnsemblMetazoaiC08B11.7.1; C08B11.7.1; WBGene00006724
C08B11.7.2; C08B11.7.2; WBGene00006724
GeneIDi174289
KEGGicel:CELE_C08B11.7
UCSCiC08B11.7 c. elegans

Similar proteinsi

Entry informationi

Entry nameiUBH4_CAEEL
AccessioniPrimary (citable) accession number: Q09444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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