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Entry version 131 (13 Nov 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Thioredoxin-1

Gene

trx-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:16324156, PubMed:16387300). Shown to facilitate the reduction of insulin disulfide bonds (PubMed:16324156, PubMed:16387300). Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide (PubMed:30014846). Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to a NO stimulus, whereas de-nitrosylation activity might promote calcium flux when NO is diminished (PubMed:30014846). By regulating the NO-induced ASJ sensory neuron activity, mediates the avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846). Positively regulates life span extension under normal and caloric restriction conditions, dauer formation and the oxidative stress response (PubMed:16387300, PubMed:16324156, PubMed:21334311, PubMed:21304598, PubMed:26920757). Contributes to the down-regulation of expression of the insulin-like neuropeptide daf-28 in the ASJ neurons in a redox-independent fashion, thereby promoting dauer formation (PubMed:21304598). Negatively regulates the nuclear localization of the intestinal skn-1 transcription factor in a p38 MAPK pathway-dependent and redox-independent fashion (PubMed:26920757).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei33Deprotonates C-terminal active site CysBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei39NucleophileBy similarity1
Sitei40Contributes to redox potential valueBy similarity1
Sitei41Contributes to redox potential valueBy similarity1
Active sitei42NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3299685 Detoxification of Reactive Oxygen Species
R-CEL-499943 Interconversion of nucleotide di- and triphosphates
R-CEL-5628897 TP53 Regulates Metabolic Genes
R-CEL-5676934 Protein repair
R-CEL-844456 The NLRP3 inflammasome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thioredoxin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trx-1
ORF Names:B0228.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
B0228.5a ; CE01745 ; WBGene00015062 ; trx-1
B0228.5b ; CE34629 ; WBGene00015062 ; trx-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased nitric oxide-evoked calcium flux to cytoplasm in ASJ sensory neurons (PubMed:30014846). Decreased avoidance of P.aeruginosa (PubMed:30014846). Decrease in lifespan (PubMed:16387300, PubMed:16324156). Suppression of lifespan extension induced by dietary deprivation or in an eat-2(ad1116) mutant background and partial suppression in a daf-2(e1370) mutant background (PubMed:21334311). Enhancement of the constitutive dauer formation phenotype in a daf-11(ks67), daf-11(m47), daf-11(sa195), daf-7(e1372), daf-1(e1287) or daf-8(e1393) mutant background at 15 degrees Celsius (PubMed:21304598). Suppression of the constitutive dauer formation phenotype in a daf-11(sa195), daf-28(tm2308) or daf-28(sa191) mutant background at 25 degrees Celsius (PubMed:21304598). Failure in down-regulation of daf-28 expression during dauer stage (PubMed:21304598). Decreased survival when facing oxidative stress upon exposure to sodium arsenite or paraquat (PubMed:26920757, PubMed:16324156). Increased localization of skn-1 to the nuclei of intestinal cells (PubMed:26920757). Suppression of skn-1 nuclear localization in a nsy-1(ok593), sek-1(km4) or pmk-1(km25) mutant background (PubMed:26920757).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39 – 42CGPC → SGPS: No change in suppression of the constitutive dauer formation phenotype in a daf-28(sa191) mutant background. No impact on skn-1 nuclear localization. 2 Publications4
Mutagenesisi39C → S in nu517; abolishes the calcium flux to the cytoplasm in the ASJ sensory neurons in response to the removal of a nitric oxide stimulus. No defect in P.aeruginosa avoidance. 1 Publication1
Mutagenesisi73C → S: Elimination of the nitric oxide-evoked calcium flux to the cytoplasm in ASJ sensory neurons. Defect in avoidance of P.aeruginosa. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001200271 – 115Thioredoxin-1Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 42Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09433

PeptideAtlas

More...
PeptideAtlasi
Q09433

PRoteomics IDEntifications database

More...
PRIDEi
Q09433

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in ASJ and ASI ciliated sensory neurons (PubMed:16387300, PubMed:21304598, PubMed:16324156, PubMed:21334311). Expressed in the intestine (at protein level) (PubMed:16324156).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in larval stages L2 and L3 and increased expression during dauer stage (PubMed:21304598). Expressed in adult animals with increased expression in 10-day-old animals (PubMed:16324156).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to dietary restriction and during dauer formation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00015062 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.B0228.5a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09433

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 114ThioredoxinPROSITE-ProRule annotationAdd BLAST113

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0907 Eukaryota
COG0526 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000292977

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09433

KEGG Orthology (KO)

More...
KOi
K03671

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIKICKF

Database of Orthologous Groups

More...
OrthoDBi
1482186at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09433

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00085 Thioredoxin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000077 Thioredoxin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q09433-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKRCNFKNQ VKYFQSDFEQ LIRQHPEKII ILDFYATWCG PCKAIAPLYK
60 70 80 90 100
ELATTHKGII FCKVDVDEAE DLCSKYDVKM MPTFIFTKNG DAIEALEGCV
110
EDELRQKVLE HVSAQ
Length:115
Mass (Da):13,323
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i073F51A3EA97AD4B
GO
Isoform b (identifier: Q09433-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: LKRCNFKNQVKYFQ → SLTKEPILELADM

Show »
Length:114
Mass (Da):12,967
Checksum:i6230D5AA54192045
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0192852 – 15LKRCN…VKYFQ → SLTKEPILELADM in isoform b. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ241299 mRNA Translation: ABB45863.1
DQ241300 mRNA Translation: ABB45864.1
FO080130 Genomic DNA Translation: CCD61448.1
FO080130 Genomic DNA Translation: CCD61449.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T29044

NCBI Reference Sequences

More...
RefSeqi
NP_001021885.1, NM_001026714.3 [Q09433-1]
NP_001021886.1, NM_001026715.4 [Q09433-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0228.5a.1; B0228.5a.1; WBGene00015062 [Q09433-1]
B0228.5b.1; B0228.5b.1; WBGene00015062 [Q09433-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_B0228.5

UCSC genome browser

More...
UCSCi
B0228.5b c. elegans [Q09433-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ241299 mRNA Translation: ABB45863.1
DQ241300 mRNA Translation: ABB45864.1
FO080130 Genomic DNA Translation: CCD61448.1
FO080130 Genomic DNA Translation: CCD61449.1
PIRiT29044
RefSeqiNP_001021885.1, NM_001026714.3 [Q09433-1]
NP_001021886.1, NM_001026715.4 [Q09433-2]

3D structure databases

SMRiQ09433
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.B0228.5a

Proteomic databases

PaxDbiQ09433
PeptideAtlasiQ09433
PRIDEiQ09433

Genome annotation databases

EnsemblMetazoaiB0228.5a.1; B0228.5a.1; WBGene00015062 [Q09433-1]
B0228.5b.1; B0228.5b.1; WBGene00015062 [Q09433-2]
GeneIDi181863
KEGGicel:CELE_B0228.5
UCSCiB0228.5b c. elegans [Q09433-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181863
WormBaseiB0228.5a ; CE01745 ; WBGene00015062 ; trx-1
B0228.5b ; CE34629 ; WBGene00015062 ; trx-1

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
HOGENOMiHOG000292977
InParanoidiQ09433
KOiK03671
OMAiKIKICKF
OrthoDBi1482186at2759
PhylomeDBiQ09433

Enzyme and pathway databases

ReactomeiR-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3299685 Detoxification of Reactive Oxygen Species
R-CEL-499943 Interconversion of nucleotide di- and triphosphates
R-CEL-5628897 TP53 Regulates Metabolic Genes
R-CEL-5676934 Protein repair
R-CEL-844456 The NLRP3 inflammasome

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09433

Gene expression databases

BgeeiWBGene00015062 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHIO1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09433
Secondary accession number(s): Q306X0, Q7YZF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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