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UniProtKB - Q09429 (ABCC8_RAT)

Entry version 160 (03 Jul 2019)
Sequence version 4 (23 Jan 2007)
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Protein

ATP-binding cassette sub-family C member 8

Gene

Abcc8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi713 – 720ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1379 – 1386ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-1296025 ATP sensitive Potassium channels
R-RNO-422356 Regulation of insulin secretion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 8
Alternative name(s):
Sulfonylurea receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc8
Synonyms:Sur, Sur1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...RGDi		3786 Abcc8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini56 – 75CytoplasmicBy similarityAdd BLAST20
Transmembranei76 – 96Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini97 – 101ExtracellularBy similarity5
Transmembranei102 – 122Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini123 – 134CytoplasmicBy similarityAdd BLAST12
Transmembranei135 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST20
Topological domaini155 – 168ExtracellularBy similarityAdd BLAST14
Transmembranei169 – 194Helical; Name=5PROSITE-ProRule annotationAdd BLAST26
Topological domaini195 – 311CytoplasmicBy similarityAdd BLAST117
Transmembranei312 – 331Helical; Name=6PROSITE-ProRule annotationAdd BLAST20
Topological domaini332 – 355ExtracellularBy similarityAdd BLAST24
Transmembranei356 – 376Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini377 – 434CytoplasmicBy similarityAdd BLAST58
Transmembranei435 – 455Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini456 – 458ExtracellularBy similarity3
Transmembranei459 – 479Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini480 – 541CytoplasmicBy similarityAdd BLAST62
Transmembranei542 – 562Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini563 – 584ExtracellularBy similarityAdd BLAST22
Transmembranei585 – 605Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini606 – 1005CytoplasmicBy similarityAdd BLAST400
Transmembranei1006 – 1026Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1027 – 1073ExtracellularBy similarityAdd BLAST47
Transmembranei1074 – 1094Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1095 – 1138CytoplasmicBy similarityAdd BLAST44
Transmembranei1139 – 1159Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1160ExtracellularBy similarity1
Transmembranei1161 – 1181Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1182 – 1252CytoplasmicBy similarityAdd BLAST71
Transmembranei1253 – 1273Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1274 – 1277ExtracellularBy similarity4
Transmembranei1278 – 1298Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1299 – 1582CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1944490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000934011 – 1582ATP-binding cassette sub-family C member 8Add BLAST1582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1050N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q09429

PRoteomics IDEntifications database

More...PRIDEi		Q09429

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q09429

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000021130 Expressed in 8 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q09429 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNJ11.

By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q09429

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000028696

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q09429

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini299 – 602ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST304
Domaini679 – 930ABC transporter 1PROSITE-ProRule annotationAdd BLAST252
Domaini1013 – 1307ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST295
Domaini1345 – 1579ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156626

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q09429

KEGG Orthology (KO)

More...KOi		K05032

Identification of Orthologs from Complete Genome Data

More...OMAi		QGQASKY

Database of Orthologous Groups

More...OrthoDBi		138195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q09429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR000844 ABCC8
IPR027417 P-loop_NTPase
IPR000388 Sulphorea_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR24223:SF187 PTHR24223:SF187, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01093 SULFNYLUR1
PR01092 SULFNYLUREAR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform A (identifier: Q09429-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED 
       760        770        780        790        800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK 
       810        820        830        840        850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV 
       860        870        880        890        900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI 
       910        920        930        940        950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP 
       960        970        980        990       1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA 
      1010       1020       1030       1040       1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN 
      1060       1070       1080       1090       1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS 
      1110       1120       1130       1140       1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC 
      1160       1170       1180       1190       1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL 
      1210       1220       1230       1240       1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV 
      1260       1270       1280       1290       1300
RMEYIGACVV LIAAATSISN SLHRELSAGL VGLGLTYALM VSNYLNWMVR 
      1310       1320       1330       1340       1350
NLADMEIQLG AVKRIHTLLK TEAESYEGLL APSLIPKNWP DQGKIQIQNL 
      1360       1370       1380       1390       1400
SVRYDSSLKP VLKHVNALIS PGQKIGICGR TGSGKSSFSL AFFRMVDMFE 
      1410       1420       1430       1440       1450
GRIIIDGIDI AKLPLHTLRS RLSIILQDPV LFSGTIRFNL DPEKKCSDST 
      1460       1470       1480       1490       1500
LWEALEIAQL KLVVKALPGG LDAIITEGGE NFSQGQRQLF CLARAFVRKT 
      1510       1520       1530       1540       1550
SIFIMDEATA SIDMATENIL QKVVMTAFAD RTVVTIAHRV HTILSADLVM 
      1560       1570       1580 
VLKRGAILEF DKPEKLLSQK DSVFASFVRA DK
Length:1,582
Mass (Da):177,185
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C57A1CFC86B9214
GO
Isoform B (identifier: Q09429-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1252-1289: Missing.

Show »
Length:1,544
Mass (Da):173,324
Checksum:i338163E4F264FCFE
GO
Isoform C (identifier: Q09429-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-741: Missing.

Show »
Length:1,581
Mass (Da):177,097
Checksum:i722EC6057F4333BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti487S → T in AAA99237 (PubMed:7716547).Curated1
Sequence conflicti699I → T in BAB19011 (Ref. 4) Curated1
Sequence conflicti836 – 837QR → PG in AAA99237 (PubMed:7716547).Curated2
Sequence conflicti1314R → G in AAA99237 (PubMed:7716547).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000056741Missing in isoform C. 1 Publication1
Alternative sequenceiVSP_0000571252 – 1289Missing in isoform B. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L40624 mRNA Translation: AAA99237.1
X97279 mRNA Translation: CAA65934.1
AF039595 mRNA Translation: AAB96684.1
AB052294 mRNA Translation: BAB19011.1

NCBI Reference Sequences

More...RefSeqi		NP_037171.2, NM_013039.2 [Q09429-1]
XP_008757542.1, XM_008759320.2 [Q09429-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130 [Q09429-1]
ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130 [Q09429-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:25559

UCSC genome browser

More...UCSCi		RGD:3786 rat [Q09429-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40624 mRNA Translation: AAA99237.1
X97279 mRNA Translation: CAA65934.1
AF039595 mRNA Translation: AAB96684.1
AB052294 mRNA Translation: BAB19011.1
RefSeqiNP_037171.2, NM_013039.2 [Q09429-1]
XP_008757542.1, XM_008759320.2 [Q09429-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1
CORUMiQ09429
STRINGi10116.ENSRNOP00000028696

Chemistry databases

BindingDBiQ09429
ChEMBLiCHEMBL1944490

PTM databases

iPTMnetiQ09429

Proteomic databases

PaxDbiQ09429
PRIDEiQ09429

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130 [Q09429-1]
ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130 [Q09429-2]
GeneIDi25559
KEGGirno:25559
UCSCiRGD:3786 rat [Q09429-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6833
RGDi3786 Abcc8

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000156626
InParanoidiQ09429
KOiK05032
OMAiQGQASKY
OrthoDBi138195at2759
PhylomeDBiQ09429

Enzyme and pathway databases

ReactomeiR-RNO-1296025 ATP sensitive Potassium channels
R-RNO-422356 Regulation of insulin secretion

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q09429

Gene expression databases

BgeeiENSRNOG00000021130 Expressed in 8 organ(s), highest expression level in heart
GenevisibleiQ09429 RN

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR000844 ABCC8
IPR027417 P-loop_NTPase
IPR000388 Sulphorea_rcpt
PANTHERiPTHR24223:SF187 PTHR24223:SF187, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PRINTSiPR01093 SULFNYLUR1
PR01092 SULFNYLUREAR
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCC8_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09429
Secondary accession number(s): O54989, P70532, Q9EQT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 3, 2019
This is version 160 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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