Abcc8

Functionⁱ

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K⁺ channels and insulin release.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	713 – 720	ATP 1PROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1379 – 1386	ATP 2PROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity, coupled to transmembrane movement of substances
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP binding Source: UniProtKB-KW
ion channel binding Source: Ensembl
potassium channel activity Source: UniProtKB
sulfonylurea receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular glucose homeostasis
Source: RGD
Inferred from mutant phenotypeⁱ
- 23828271
cellular response to organic substance
Source: RGD
Inferred from direct assayⁱ
- 15613469
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 21527399
memory
Source: RGD
Inferred from mutant phenotypeⁱ
- 24114458
negative regulation of angiogenesis
Source: RGD
Inferred from mutant phenotypeⁱ
- 23149556
negative regulation of glial cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 23149556
negative regulation of insulin secretion
Source: RGD
Inferred from direct assayⁱ
- 15163199
negative regulation of low-density lipoprotein particle clearance
Source: RGD
Inferred from mutant phenotypeⁱ
- 23828271
negative regulation of maintenance of permeability of blood-brain barrier
Source: RGD
Inferred from mutant phenotypeⁱ
- 18854840
negative regulation of neuroblast migration
Source: RGD
Inferred from mutant phenotypeⁱ
- 23149556
negative regulation of neurogenesis
Source: RGD
Inferred from mutant phenotypeⁱ
- 23149556
negative regulation of wound healing
Source: RGD
Inferred from mutant phenotypeⁱ
- 20410530
positive regulation of potassium ion transport
Source: RGD
Inferred from direct assayⁱ
- 15962003
positive regulation of tight junction disassembly
Source: RGD
Inferred from mutant phenotypeⁱ
- 23633925
positive regulation of tumor necrosis factor production
Source: RGD
Inferred from mutant phenotypeⁱ
- 18854840
positive regulation of uterine smooth muscle relaxation
Source: RGD
Inferred from mutant phenotypeⁱ
- 25891870
positive regulation of voltage-gated potassium channel activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 12183335
response to drug
Source: RGD
Inferred from expression patternⁱ
- 17174476
response to insulin
Source: RGD
Inferred from expression patternⁱ
- 18084728
response to lipopolysaccharide
Source: RGD
Inferred from expression patternⁱ
- 17285300
response to pH
Source: RGD
Inferred from direct assayⁱ
- 15613469
response to zinc ion
Source: RGD
Inferred from direct assayⁱ
- 15613469
transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
visual learning
Source: RGD
Inferred from mutant phenotypeⁱ
- 24114458

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-binding cassette sub-family C member 8 Alternative name(s): Sulfonylurea receptor 1
Gene namesⁱ	Name:Abcc8 Synonyms:Sur, Sur1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	3786 Abcc8

RGDⁱ

3786 Abcc8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 34	ExtracellularBy similarityAdd BLAST	34
Transmembraneⁱ	35 – 55	Helical; Name=1PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	56 – 75	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	76 – 96	Helical; Name=2PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	97 – 101	ExtracellularBy similarity	5
Transmembraneⁱ	102 – 122	Helical; Name=3PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	123 – 134	CytoplasmicBy similarityAdd BLAST	12
Transmembraneⁱ	135 – 154	Helical; Name=4PROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	155 – 168	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	169 – 194	Helical; Name=5PROSITE-ProRule annotationAdd BLAST	26
Topological domainⁱ	195 – 311	CytoplasmicBy similarityAdd BLAST	117
Transmembraneⁱ	312 – 331	Helical; Name=6PROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	332 – 355	ExtracellularBy similarityAdd BLAST	24
Transmembraneⁱ	356 – 376	Helical; Name=7PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	377 – 434	CytoplasmicBy similarityAdd BLAST	58
Transmembraneⁱ	435 – 455	Helical; Name=8PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	456 – 458	ExtracellularBy similarity	3
Transmembraneⁱ	459 – 479	Helical; Name=9PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	480 – 541	CytoplasmicBy similarityAdd BLAST	62
Transmembraneⁱ	542 – 562	Helical; Name=10PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	563 – 584	ExtracellularBy similarityAdd BLAST	22
Transmembraneⁱ	585 – 605	Helical; Name=11PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	606 – 1005	CytoplasmicBy similarityAdd BLAST	400
Transmembraneⁱ	1006 – 1026	Helical; Name=12PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1027 – 1073	ExtracellularBy similarityAdd BLAST	47
Transmembraneⁱ	1074 – 1094	Helical; Name=13PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1095 – 1138	CytoplasmicBy similarityAdd BLAST	44
Transmembraneⁱ	1139 – 1159	Helical; Name=14PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1160	ExtracellularBy similarity	1
Transmembraneⁱ	1161 – 1181	Helical; Name=15PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1182 – 1252	CytoplasmicBy similarityAdd BLAST	71
Transmembraneⁱ	1253 – 1273	Helical; Name=16PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1274 – 1277	ExtracellularBy similarity	4
Transmembraneⁱ	1278 – 1298	Helical; Name=17PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1299 – 1582	CytoplasmicBy similarityAdd BLAST	284

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL1944490

ChEMBLⁱ

CHEMBL1944490

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093401	1 – 1582	ATP-binding cassette sub-family C member 8Add BLAST		1582

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	10	N-linked (GlcNAc...) asparagine1 Publication		1
Glycosylationⁱ	1050	N-linked (GlcNAc...) asparagineBy similarity		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q09429
PRIDEⁱ	Q09429

PTM databases

iPTMnetⁱ	Q09429

iPTMnetⁱ

Q09429

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000021130 Expressed in 8 organ(s), highest expression level in heart
Genevisibleⁱ	Q09429 RN

Interactionⁱ

Subunit structureⁱ

Interacts with KCNJ11.By similarity

GO - Molecular functionⁱ

ion channel binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1
CORUMⁱ	Q09429
STRINGⁱ	10116.ENSRNOP00000028696

Chemistry databases

BindingDBⁱ

Q09429

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q09429
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	299 – 602	ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST	304
Domainⁱ	679 – 930	ABC transporter 1PROSITE-ProRule annotationAdd BLAST	252
Domainⁱ	1013 – 1307	ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST	295
Domainⁱ	1345 – 1579	ABC transporter 2PROSITE-ProRule annotationAdd BLAST	235

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0054 Eukaryota COG1132 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137856
HOVERGENⁱ	HBG101342
InParanoidⁱ	Q09429
KEGG Orthology (KO) More...KOⁱ	K05032
OMAⁱ	QGQASKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00IN
PhylomeDBⁱ	Q09429

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR000844 ABCC8 IPR027417 P-loop_NTPase IPR000388 Sulphorea_rcpt
PANTHERⁱ	PTHR24223:SF187 PTHR24223:SF187, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
PRINTSⁱ	PR01093 SULFNYLUR1 PR01092 SULFNYLUREAR
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform A (identifier: Q09429-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED 
       760        770        780        790        800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK 
       810        820        830        840        850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV 
       860        870        880        890        900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI 
       910        920        930        940        950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP 
       960        970        980        990       1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA 
      1010       1020       1030       1040       1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN 
      1060       1070       1080       1090       1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS 
      1110       1120       1130       1140       1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC 
      1160       1170       1180       1190       1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL 
      1210       1220       1230       1240       1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV 
      1260       1270       1280       1290       1300
RMEYIGACVV LIAAATSISN SLHRELSAGL VGLGLTYALM VSNYLNWMVR 
      1310       1320       1330       1340       1350
NLADMEIQLG AVKRIHTLLK TEAESYEGLL APSLIPKNWP DQGKIQIQNL 
      1360       1370       1380       1390       1400
SVRYDSSLKP VLKHVNALIS PGQKIGICGR TGSGKSSFSL AFFRMVDMFE 
      1410       1420       1430       1440       1450
GRIIIDGIDI AKLPLHTLRS RLSIILQDPV LFSGTIRFNL DPEKKCSDST 
      1460       1470       1480       1490       1500
LWEALEIAQL KLVVKALPGG LDAIITEGGE NFSQGQRQLF CLARAFVRKT 
      1510       1520       1530       1540       1550
SIFIMDEATA SIDMATENIL QKVVMTAFAD RTVVTIAHRV HTILSADLVM 
      1560       1570       1580 
VLKRGAILEF DKPEKLLSQK DSVFASFVRA DK

Length:1,582

Mass (Da):177,185

Last modified:January 23, 2007 - v4

Checksum:ⁱ7C57A1CFC86B9214

GO

Isoform B (identifier: Q09429-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1252-1289: Missing.

« Hide

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED 
       760        770        780        790        800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK 
       810        820        830        840        850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV 
       860        870        880        890        900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI 
       910        920        930        940        950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP 
       960        970        980        990       1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA 
      1010       1020       1030       1040       1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN 
      1060       1070       1080       1090       1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS 
      1110       1120       1130       1140       1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC 
      1160       1170       1180       1190       1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL 
      1210       1220       1230       1240       1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV 
      1260       1270       1280       1290       1300
RMVSNYLNWM VRNLADMEIQ LGAVKRIHTL LKTEAESYEG LLAPSLIPKN 
      1310       1320       1330       1340       1350
WPDQGKIQIQ NLSVRYDSSL KPVLKHVNAL ISPGQKIGIC GRTGSGKSSF 
      1360       1370       1380       1390       1400
SLAFFRMVDM FEGRIIIDGI DIAKLPLHTL RSRLSIILQD PVLFSGTIRF 
      1410       1420       1430       1440       1450
NLDPEKKCSD STLWEALEIA QLKLVVKALP GGLDAIITEG GENFSQGQRQ 
      1460       1470       1480       1490       1500
LFCLARAFVR KTSIFIMDEA TASIDMATEN ILQKVVMTAF ADRTVVTIAH 
      1510       1520       1530       1540 
RVHTILSADL VMVLKRGAIL EFDKPEKLLS QKDSVFASFV RADK

Show »

Length:1,544

Mass (Da):173,324

Checksum:ⁱ338163E4F264FCFE

GO

Isoform C (identifier: Q09429-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
741-741: Missing.

« Hide

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SLPDSEGEDP 
       760        770        780        790        800
SNPERETAAD SDARSRGPVA YASQKPWLLN ATVEENITFE SPFNKQRYKM 
       810        820        830        840        850
VIEACSLQPD IDILPHGDQT QIGERGINLS GGQRQRISVA RALYQHTNVV 
       860        870        880        890        900
FLDDPFSALD VHLSDHLMQA GILELLRDDK RTVVLVTHKL QYLPHADWII 
       910        920        930        940        950
AMKDGTIQRE GTLKDFQRSE CQLFEHWKTL MNRQDQELEK ETVMERKAPE 
       960        970        980        990       1000
PSQGLPRAMS SRDGLLLDED EEEEEAAESE EDDNLSSVLH QRAKIPWRAC 
      1010       1020       1030       1040       1050
TKYLSSAGIL LLSLLVFSQL LKHMVLVAID YWLAKWTDSA LVLSPAARNC 
      1060       1070       1080       1090       1100
SLSQECALDQ SVYAMVFTVL CSLGIALCLV TSVTVEWTGL KVAKRLHRSL 
      1110       1120       1130       1140       1150
LNRIILAPMR FFETTPLGSI LNRFSSDCNT IDQHIPSTLE CLSRSTLLCV 
      1160       1170       1180       1190       1200
SALAVISYVT PVFLVALLPL AVVCYFIQKY FRVASRDLQQ LDDTTQLPLL 
      1210       1220       1230       1240       1250
SHFAETVEGL TTIRAFRYEA RFQQKLLEYT DSNNIASLFL TAANRWLEVR 
      1260       1270       1280       1290       1300
MEYIGACVVL IAAATSISNS LHRELSAGLV GLGLTYALMV SNYLNWMVRN 
      1310       1320       1330       1340       1350
LADMEIQLGA VKRIHTLLKT EAESYEGLLA PSLIPKNWPD QGKIQIQNLS 
      1360       1370       1380       1390       1400
VRYDSSLKPV LKHVNALISP GQKIGICGRT GSGKSSFSLA FFRMVDMFEG 
      1410       1420       1430       1440       1450
RIIIDGIDIA KLPLHTLRSR LSIILQDPVL FSGTIRFNLD PEKKCSDSTL 
      1460       1470       1480       1490       1500
WEALEIAQLK LVVKALPGGL DAIITEGGEN FSQGQRQLFC LARAFVRKTS 
      1510       1520       1530       1540       1550
IFIMDEATAS IDMATENILQ KVVMTAFADR TVVTIAHRVH TILSADLVMV 
      1560       1570       1580 
LKRGAILEFD KPEKLLSQKD SVFASFVRAD K

Show »

Length:1,581

Mass (Da):177,097

Checksum:ⁱ722EC6057F4333BC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	487	S → T in AAA99237 (PubMed:7716547).Curated	1
Sequence conflictⁱ	699	I → T in BAB19011 (Ref. 4) Curated	1
Sequence conflictⁱ	836 – 837	QR → PG in AAA99237 (PubMed:7716547).Curated	2
Sequence conflictⁱ	1314	R → G in AAA99237 (PubMed:7716547).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000056	741	Missing in isoform C. 1 Publication		1
Alternative sequenceⁱVSP_000057	1252 – 1289	Missing in isoform B. 1 PublicationAdd BLAST		38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L40624 mRNA Translation: AAA99237.1 X97279 mRNA Translation: CAA65934.1 AF039595 mRNA Translation: AAB96684.1 AB052294 mRNA Translation: BAB19011.1
NCBI Reference Sequences More...RefSeqⁱ	NP_037171.2, NM_013039.2 [Q09429-1] XP_008757542.1, XM_008759320.2 [Q09429-3]
UniGeneⁱ	Rn.11187

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130 [Q09429-1] ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130 [Q09429-2]
GeneIDⁱ	25559
KEGGⁱ	rno:25559
UCSC genome browser More...UCSCⁱ	RGD:3786 rat [Q09429-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q09429	ATP-binding cassette sub-family C member 8	)	CRICR		1582	UniRef90_Q09429
Uncharacterized protein		ICTTR		1624
ATP-binding cassette sub-family C member 8 isoform X1		MESAU		1595
ATP-binding cassette sub-family C member 8 isoform X2		DIPOR		1595
Uncharacterized protein		OTOGA		1594
+174

Protein	Similar proteins		Species	Score	Length	Source
Q09429	ATP-binding cassette sub-family C member 8	)	HUMAN		1581	UniRef50_Q09428
ATP-binding cassette sub-family C member 8	)	CRICR		1582
Uncharacterized protein		RHIRO		1585
Uncharacterized protein		RHIBE		1585
Uncharacterized protein		MANLE		1582
+867
Q09429-2	Uncharacterized protein		AOTNA		1561	UniRef50_Q09429-2
ATP binding cassette subfamily C member 8		SAIBB		1555
Uncharacterized protein		MACFA		1596
Uncharacterized protein		MACMU		1655
ATP-binding cassette transporter sub-family C member 8-like protein		CAMFR		1631
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L40624 mRNA Translation: AAA99237.1 X97279 mRNA Translation: CAA65934.1 AF039595 mRNA Translation: AAB96684.1 AB052294 mRNA Translation: BAB19011.1
RefSeqⁱ	NP_037171.2, NM_013039.2 [Q09429-1] XP_008757542.1, XM_008759320.2 [Q09429-3]
UniGeneⁱ	Rn.11187

3D structure databases

ProteinModelPortalⁱ	Q09429
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1
CORUMⁱ	Q09429
STRINGⁱ	10116.ENSRNOP00000028696

Chemistry databases

BindingDBⁱ	Q09429
ChEMBLⁱ	CHEMBL1944490

PTM databases

iPTMnetⁱ	Q09429

iPTMnetⁱ

Q09429

Proteomic databases

PaxDbⁱ	Q09429
PRIDEⁱ	Q09429

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130 [Q09429-1] ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130 [Q09429-2]
GeneIDⁱ	25559
KEGGⁱ	rno:25559
UCSCⁱ	RGD:3786 rat [Q09429-1]

Organism-specific databases

CTDⁱ	6833
RGDⁱ	3786 Abcc8

Phylogenomic databases

eggNOGⁱ	KOG0054 Eukaryota COG1132 LUCA
GeneTreeⁱ	ENSGT00880000137856
HOVERGENⁱ	HBG101342
InParanoidⁱ	Q09429
KOⁱ	K05032
OMAⁱ	QGQASKY
OrthoDBⁱ	EOG091G00IN
PhylomeDBⁱ	Q09429

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q09429

PROⁱ

PR:Q09429

Gene expression databases

Bgeeⁱ	ENSRNOG00000021130 Expressed in 8 organ(s), highest expression level in heart
Genevisibleⁱ	Q09429 RN

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR000844 ABCC8 IPR027417 P-loop_NTPase IPR000388 Sulphorea_rcpt
PANTHERⁱ	PTHR24223:SF187 PTHR24223:SF187, 1 hit
Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
PRINTSⁱ	PR01093 SULFNYLUR1 PR01092 SULFNYLUREAR
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ABCC8_RAT
Accessionⁱ	Q09429Primary (citable) accession number: Q09429 Secondary accession number(s): O54989, P70532, Q9EQT0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q09429 (ABCC8_RAT)

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ATP-binding cassette sub-family C member 8

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ