ATP-binding cassette sub-family C member 8

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity Source: RGDInferred from sequence orthologyⁱ
  • "Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity."
    Fatehi M., Carter C.R., Youssef N., Hunter B.E., Holt A., Light P.E.
    Biosci. Rep. 35:0-0(2015) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: UniProtKB-KW
• ion channel binding Source: RGDInferred from sequence orthologyⁱ
  • "Ankyrin-B regulates Kir6.2 membrane expression and function in heart."
    Li J., Kline C.F., Hund T.J., Anderson M.E., Mohler P.J.
    J. Biol. Chem. 285:28723-28730(2010) [PubMed] [Europe PMC] [Abstract]
• potassium channel activity Source: UniProtKB
• sulfonylurea receptor activity Source: InterPro

GO - Biological processⁱ

• cellular glucose homeostasis Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Antihyperglycemic and antihyperlipidemic effects of newly synthesized glibenclamide analogues on streptozotocin-diabetic rats."
    Ahmadi A., Khalili M., Farsadrooh M., Ghiasi M., Nahri-Niknafs B.
    Drug Res (Stuttg) 63:614-619(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic substance Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel."
    Bancila V., Cens T., Monnier D., Chanson F., Faure C., Dunant Y., Bloc A.
    J. Biol. Chem. 280:8793-8799(2005) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium."
    Lovasz N., Ducza E., Gaspar R., Falkay G.
    Reproduction 142:175-181(2011) [PubMed] [Europe PMC] [Abstract]
• memory Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage."
    Tosun C., Kurland D.B., Mehta R., Castellani R.J., deJong J.L., Kwon M.S., Woo S.K., Gerzanich V., Simard J.M.
    Stroke 44:3522-3528(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia."
    Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J.
    J. Cereb. Blood Flow Metab. 33:356-364(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia."
    Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J.
    J. Cereb. Blood Flow Metab. 33:356-364(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion Source: RGDInferred from direct assayⁱ
  • "Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release."
    Tagmose T.M., Schou S.C., Mogensen J.P., Nielsen F.E., Arkhammar P.O., Wahl P., Hansen B.S., Worsaae A., Boonen H.C., Antoine M.H., Lebrun P., Hansen J.B.
    J. Med. Chem. 47:3202-3211(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of low-density lipoprotein particle clearance Source: RGDInferred from mutant phenotypeⁱ
  • "Antihyperglycemic and antihyperlipidemic effects of newly synthesized glibenclamide analogues on streptozotocin-diabetic rats."
    Ahmadi A., Khalili M., Farsadrooh M., Ghiasi M., Nahri-Niknafs B.
    Drug Res (Stuttg) 63:614-619(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of maintenance of permeability of blood-brain barrier Source: RGDInferred from mutant phenotypeⁱ
  • "Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage."
    Simard J.M., Geng Z., Woo S.K., Ivanova S., Tosun C., Melnichenko L., Gerzanich V.
    J. Cereb. Blood Flow Metab. 29:317-330(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuroblast migration Source: RGDInferred from mutant phenotypeⁱ
  • "Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia."
    Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J.
    J. Cereb. Blood Flow Metab. 33:356-364(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia."
    Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J.
    J. Cereb. Blood Flow Metab. 33:356-364(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of wound healing Source: RGDInferred from mutant phenotypeⁱ
  • "Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma."
    Simard J.M., Woo S.K., Norenberg M.D., Tosun C., Chen Z., Ivanova S., Tsymbalyuk O., Bryan J., Landsman D., Gerzanich V.
    Sci Transl Med 2:28ra29-28ra29(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of potassium ion transport Source: RGDInferred from direct assayⁱ
  • "Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions."
    Tammaro P., Girard C., Molnes J., Njolstad P.R., Ashcroft F.M.
    EMBO J. 24:2318-2330(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tight junction disassembly Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of SUR1 decreases the vascular permeability of cerebral metastases."
    Thompson E.M., Pishko G.L., Muldoon L.L., Neuwelt E.A.
    Neoplasia 15:535-543(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: RGDInferred from mutant phenotypeⁱ
  • "Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage."
    Simard J.M., Geng Z., Woo S.K., Ivanova S., Tosun C., Melnichenko L., Gerzanich V.
    J. Cereb. Blood Flow Metab. 29:317-330(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of uterine smooth muscle relaxation Source: RGDInferred from mutant phenotypeⁱ
  • "ATP-sensitive potassium channels modulate in vitro tocolytic effects of beta(2)-adrenergic receptor agonists on uterine muscle rings in rats in early but not in late pregnancy."
    Lovasz N., Koncz A., Domokos D., Gaspar R., Falkay G.
    Croat. Med. J. 56:114-118(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of voltage-gated potassium channel activity Source: RGDInferred from mutant phenotypeⁱ
  • "Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31."
    Gros L., Trapp S., Dabrowski M., Ashcroft F.M., Bataille D., Blache P.
    Br. J. Pharmacol. 137:98-106(2002) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells."
    Ota M., Nakashima A., Kaneko Y.S., Mori K., Takami G., Ota A.
    Neurosci. Lett. 412:254-258(2007) [PubMed] [Europe PMC] [Abstract]
• response to insulin Source: RGDInferred from expression patternⁱ
  • "Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol."
    Vavaiya K.V., Briski K.P.
    J. Mol. Neurosci. 34:121-129(2008) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia."
    Heemskerk S., van Koppen A., van den Broek L., Poelen G.J., Wouterse A.C., Dijkman H.B., Russel F.G., Masereeuw R.
    Pflugers Arch. 454:321-334(2007) [PubMed] [Europe PMC] [Abstract]
• response to pH Source: RGDInferred from direct assayⁱ
  • "Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel."
    Bancila V., Cens T., Monnier D., Chanson F., Faure C., Dunant Y., Bloc A.
    J. Biol. Chem. 280:8793-8799(2005) [PubMed] [Europe PMC] [Abstract]
• response to zinc ion Source: RGDInferred from direct assayⁱ
  • "Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel."
    Bancila V., Cens T., Monnier D., Chanson F., Faure C., Dunant Y., Bloc A.
    J. Biol. Chem. 280:8793-8799(2005) [PubMed] [Europe PMC] [Abstract]
• transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage."
    Tosun C., Kurland D.B., Mehta R., Castellani R.J., deJong J.L., Kwon M.S., Woo S.K., Gerzanich V., Simard J.M.
    Stroke 44:3522-3528(2013) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ion channel binding Source: RGDInferred from sequence orthologyⁱ
  • "Ankyrin-B regulates Kir6.2 membrane expression and function in heart."
    Li J., Kline C.F., Hund T.J., Anderson M.E., Mohler P.J.
    J. Biol. Chem. 285:28723-28730(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED 
       760        770        780        790        800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK 
       810        820        830        840        850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV 
       860        870        880        890        900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI 
       910        920        930        940        950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP 
       960        970        980        990       1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA 
      1010       1020       1030       1040       1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN 
      1060       1070       1080       1090       1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS 
      1110       1120       1130       1140       1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC 
      1160       1170       1180       1190       1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL 
      1210       1220       1230       1240       1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV 
      1260       1270       1280       1290       1300
RMEYIGACVV LIAAATSISN SLHRELSAGL VGLGLTYALM VSNYLNWMVR 
      1310       1320       1330       1340       1350
NLADMEIQLG AVKRIHTLLK TEAESYEGLL APSLIPKNWP DQGKIQIQNL 
      1360       1370       1380       1390       1400
SVRYDSSLKP VLKHVNALIS PGQKIGICGR TGSGKSSFSL AFFRMVDMFE 
      1410       1420       1430       1440       1450
GRIIIDGIDI AKLPLHTLRS RLSIILQDPV LFSGTIRFNL DPEKKCSDST 
      1460       1470       1480       1490       1500
LWEALEIAQL KLVVKALPGG LDAIITEGGE NFSQGQRQLF CLARAFVRKT 
      1510       1520       1530       1540       1550
SIFIMDEATA SIDMATENIL QKVVMTAFAD RTVVTIAHRV HTILSADLVM 
      1560       1570       1580 
VLKRGAILEF DKPEKLLSQK DSVFASFVRA DK                    

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED 
       760        770        780        790        800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK 
       810        820        830        840        850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV 
       860        870        880        890        900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI 
       910        920        930        940        950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP 
       960        970        980        990       1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA 
      1010       1020       1030       1040       1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN 
      1060       1070       1080       1090       1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS 
      1110       1120       1130       1140       1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC 
      1160       1170       1180       1190       1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL 
      1210       1220       1230       1240       1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV 
      1260       1270       1280       1290       1300
RMVSNYLNWM VRNLADMEIQ LGAVKRIHTL LKTEAESYEG LLAPSLIPKN 
      1310       1320       1330       1340       1350
WPDQGKIQIQ NLSVRYDSSL KPVLKHVNAL ISPGQKIGIC GRTGSGKSSF 
      1360       1370       1380       1390       1400
SLAFFRMVDM FEGRIIIDGI DIAKLPLHTL RSRLSIILQD PVLFSGTIRF 
      1410       1420       1430       1440       1450
NLDPEKKCSD STLWEALEIA QLKLVVKALP GGLDAIITEG GENFSQGQRQ 
      1460       1470       1480       1490       1500
LFCLARAFVR KTSIFIMDEA TASIDMATEN ILQKVVMTAF ADRTVVTIAH 
      1510       1520       1530       1540 
RVHTILSADL VMVLKRGAIL EFDKPEKLLS QKDSVFASFV RADK       

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SLPDSEGEDP 
       760        770        780        790        800
SNPERETAAD SDARSRGPVA YASQKPWLLN ATVEENITFE SPFNKQRYKM 
       810        820        830        840        850
VIEACSLQPD IDILPHGDQT QIGERGINLS GGQRQRISVA RALYQHTNVV 
       860        870        880        890        900
FLDDPFSALD VHLSDHLMQA GILELLRDDK RTVVLVTHKL QYLPHADWII 
       910        920        930        940        950
AMKDGTIQRE GTLKDFQRSE CQLFEHWKTL MNRQDQELEK ETVMERKAPE 
       960        970        980        990       1000
PSQGLPRAMS SRDGLLLDED EEEEEAAESE EDDNLSSVLH QRAKIPWRAC 
      1010       1020       1030       1040       1050
TKYLSSAGIL LLSLLVFSQL LKHMVLVAID YWLAKWTDSA LVLSPAARNC 
      1060       1070       1080       1090       1100
SLSQECALDQ SVYAMVFTVL CSLGIALCLV TSVTVEWTGL KVAKRLHRSL 
      1110       1120       1130       1140       1150
LNRIILAPMR FFETTPLGSI LNRFSSDCNT IDQHIPSTLE CLSRSTLLCV 
      1160       1170       1180       1190       1200
SALAVISYVT PVFLVALLPL AVVCYFIQKY FRVASRDLQQ LDDTTQLPLL 
      1210       1220       1230       1240       1250
SHFAETVEGL TTIRAFRYEA RFQQKLLEYT DSNNIASLFL TAANRWLEVR 
      1260       1270       1280       1290       1300
MEYIGACVVL IAAATSISNS LHRELSAGLV GLGLTYALMV SNYLNWMVRN 
      1310       1320       1330       1340       1350
LADMEIQLGA VKRIHTLLKT EAESYEGLLA PSLIPKNWPD QGKIQIQNLS 
      1360       1370       1380       1390       1400
VRYDSSLKPV LKHVNALISP GQKIGICGRT GSGKSSFSLA FFRMVDMFEG 
      1410       1420       1430       1440       1450
RIIIDGIDIA KLPLHTLRSR LSIILQDPVL FSGTIRFNLD PEKKCSDSTL 
      1460       1470       1480       1490       1500
WEALEIAQLK LVVKALPGGL DAIITEGGEN FSQGQRQLFC LARAFVRKTS 
      1510       1520       1530       1540       1550
IFIMDEATAS IDMATENILQ KVVMTAFADR TVVTIAHRVH TILSADLVMV 
      1560       1570       1580 
LKRGAILEFD KPEKLLSQKD SVFASFVRAD K                     

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families