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UniProtKB - Q09429 (ABCC8_RAT)
Protein
ATP-binding cassette sub-family C member 8
Gene
Abcc8
Organism
Rattus norvegicus (Rat)
Status
Functioni
Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 713 – 720 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1379 – 1386 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type transporter activity Source: InterPro
- ATPase-coupled cation transmembrane transporter activity Source: RGD
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- potassium channel activity Source: UniProtKB
- sulfonylurea receptor activity Source: InterPro
- transmembrane transporter binding Source: RGD
GO - Biological processi
- cellular glucose homeostasis Source: RGD
- cellular response to organic substance Source: RGD
- female pregnancy Source: RGD
- memory Source: RGD
- negative regulation of angiogenesis Source: RGD
- negative regulation of blood-brain barrier permeability Source: RGD
- negative regulation of glial cell proliferation Source: RGD
- negative regulation of insulin secretion Source: RGD
- negative regulation of low-density lipoprotein particle clearance Source: RGD
- negative regulation of neuroblast migration Source: RGD
- negative regulation of neurogenesis Source: RGD
- negative regulation of wound healing Source: RGD
- positive regulation of potassium ion transport Source: RGD
- positive regulation of tight junction disassembly Source: RGD
- positive regulation of tumor necrosis factor production Source: RGD
- positive regulation of uterine smooth muscle relaxation Source: RGD
- positive regulation of voltage-gated potassium channel activity Source: RGD
- response to insulin Source: RGD
- response to lipopolysaccharide Source: RGD
- response to pH Source: RGD
- response to xenobiotic stimulus Source: RGD
- response to zinc ion Source: RGD
- transmembrane transport Source: GO_Central
- visual learning Source: RGD
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-1296025, ATP sensitive Potassium channels R-RNO-422356, Regulation of insulin secretion |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family C member 8Alternative name(s): Sulfonylurea receptor 1 |
Gene namesi | Name:Abcc8 Synonyms:Sur, Sur1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3786, Abcc8 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- inward rectifying potassium channel Source: RGD
- plasma membrane Source: RGD
- sarcolemma Source: RGD
Other locations
- membrane Source: GO_Central
- synaptic vesicle membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | ExtracellularBy similarityAdd BLAST | 34 | |
Transmembranei | 35 – 55 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 56 – 75 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 76 – 96 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 97 – 101 | ExtracellularBy similarity | 5 | |
Transmembranei | 102 – 122 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 123 – 134 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 135 – 154 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 155 – 168 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 169 – 194 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 26 | |
Topological domaini | 195 – 311 | CytoplasmicBy similarityAdd BLAST | 117 | |
Transmembranei | 312 – 331 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 332 – 355 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 356 – 376 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 377 – 434 | CytoplasmicBy similarityAdd BLAST | 58 | |
Transmembranei | 435 – 455 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 456 – 458 | ExtracellularBy similarity | 3 | |
Transmembranei | 459 – 479 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 480 – 541 | CytoplasmicBy similarityAdd BLAST | 62 | |
Transmembranei | 542 – 562 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 563 – 584 | ExtracellularBy similarityAdd BLAST | 22 | |
Transmembranei | 585 – 605 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 606 – 1005 | CytoplasmicBy similarityAdd BLAST | 400 | |
Transmembranei | 1006 – 1026 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1027 – 1073 | ExtracellularBy similarityAdd BLAST | 47 | |
Transmembranei | 1074 – 1094 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1095 – 1138 | CytoplasmicBy similarityAdd BLAST | 44 | |
Transmembranei | 1139 – 1159 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1160 | ExtracellularBy similarity | 1 | |
Transmembranei | 1161 – 1181 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1182 – 1252 | CytoplasmicBy similarityAdd BLAST | 71 | |
Transmembranei | 1253 – 1273 | Helical; Name=16PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1274 – 1277 | ExtracellularBy similarity | 4 | |
Transmembranei | 1278 – 1298 | Helical; Name=17PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1299 – 1582 | CytoplasmicBy similarityAdd BLAST | 284 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093401 | 1 – 1582 | ATP-binding cassette sub-family C member 8Add BLAST | 1582 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1050 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q09429 |
PRIDEi | Q09429 |
PTM databases
GlyGeni | Q09429, 2 sites |
iPTMneti | Q09429 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000021130, Expressed in cerebellum and 16 other tissues |
Genevisiblei | Q09429, RN |
Interactioni
Subunit structurei
Interacts with KCNJ11.
By similarityGO - Molecular functioni
- transmembrane transporter binding Source: RGD
Protein-protein interaction databases
ComplexPortali | CPX-186, Inward rectifying potassium channel complex, Kir6.2-SUR1 |
CORUMi | Q09429 |
STRINGi | 10116.ENSRNOP00000028696 |
Chemistry databases
BindingDBi | Q09429 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 299 – 602 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 304 | |
Domaini | 679 – 930 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 1013 – 1307 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 295 | |
Domaini | 1345 – 1579 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 741 – 768 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 939 – 962 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 749 – 763 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000156626 |
HOGENOMi | CLU_000604_27_3_1 |
InParanoidi | Q09429 |
OMAi | FFWIGHY |
OrthoDBi | 138195at2759 |
PhylomeDBi | Q09429 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR000844, ABCC8 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01093, SULFNYLUR1 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketNote: Experimental confirmation may be lacking for some isoforms.
Isoform A (identifier: Q09429-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG
60 70 80 90 100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE
110 120 130 140 150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK
160 170 180 190 200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT
210 220 230 240 250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI
260 270 280 290 300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV
310 320 330 340 350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE
360 370 380 390 400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM
410 420 430 440 450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI
460 470 480 490 500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN
510 520 530 540 550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI
560 570 580 590 600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST
610 620 630 640 650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR
660 670 680 690 700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT
710 720 730 740 750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED
760 770 780 790 800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK
810 820 830 840 850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV
860 870 880 890 900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI
910 920 930 940 950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP
960 970 980 990 1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA
1010 1020 1030 1040 1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN
1060 1070 1080 1090 1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS
1110 1120 1130 1140 1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC
1160 1170 1180 1190 1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL
1210 1220 1230 1240 1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV
1260 1270 1280 1290 1300
RMEYIGACVV LIAAATSISN SLHRELSAGL VGLGLTYALM VSNYLNWMVR
1310 1320 1330 1340 1350
NLADMEIQLG AVKRIHTLLK TEAESYEGLL APSLIPKNWP DQGKIQIQNL
1360 1370 1380 1390 1400
SVRYDSSLKP VLKHVNALIS PGQKIGICGR TGSGKSSFSL AFFRMVDMFE
1410 1420 1430 1440 1450
GRIIIDGIDI AKLPLHTLRS RLSIILQDPV LFSGTIRFNL DPEKKCSDST
1460 1470 1480 1490 1500
LWEALEIAQL KLVVKALPGG LDAIITEGGE NFSQGQRQLF CLARAFVRKT
1510 1520 1530 1540 1550
SIFIMDEATA SIDMATENIL QKVVMTAFAD RTVVTIAHRV HTILSADLVM
1560 1570 1580
VLKRGAILEF DKPEKLLSQK DSVFASFVRA DK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 487 | S → T in AAA99237 (PubMed:7716547).Curated | 1 | |
Sequence conflicti | 699 | I → T in BAB19011 (Ref. 4) Curated | 1 | |
Sequence conflicti | 836 – 837 | QR → PG in AAA99237 (PubMed:7716547).Curated | 2 | |
Sequence conflicti | 1314 | R → G in AAA99237 (PubMed:7716547).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000056 | 741 | Missing in isoform C. 1 Publication | 1 | |
Alternative sequenceiVSP_000057 | 1252 – 1289 | Missing in isoform B. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40624 mRNA Translation: AAA99237.1 X97279 mRNA Translation: CAA65934.1 AF039595 mRNA Translation: AAB96684.1 AB052294 mRNA Translation: BAB19011.1 |
RefSeqi | NP_037171.2, NM_013039.2 [Q09429-1] XP_008757542.1, XM_008759320.2 [Q09429-3] |
Genome annotation databases
Ensembli | ENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130 [Q09429-1] ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130 [Q09429-2] |
GeneIDi | 25559 |
KEGGi | rno:25559 |
UCSCi | RGD:3786, rat [Q09429-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40624 mRNA Translation: AAA99237.1 X97279 mRNA Translation: CAA65934.1 AF039595 mRNA Translation: AAB96684.1 AB052294 mRNA Translation: BAB19011.1 |
RefSeqi | NP_037171.2, NM_013039.2 [Q09429-1] XP_008757542.1, XM_008759320.2 [Q09429-3] |
3D structure databases
SMRi | Q09429 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-186, Inward rectifying potassium channel complex, Kir6.2-SUR1 |
CORUMi | Q09429 |
STRINGi | 10116.ENSRNOP00000028696 |
Chemistry databases
BindingDBi | Q09429 |
ChEMBLi | CHEMBL1944490 |
PTM databases
GlyGeni | Q09429, 2 sites |
iPTMneti | Q09429 |
Proteomic databases
PaxDbi | Q09429 |
PRIDEi | Q09429 |
Protocols and materials databases
ABCDi | Q09429, 2 sequenced antibodies |
Genome annotation databases
Ensembli | ENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130 [Q09429-1] ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130 [Q09429-2] |
GeneIDi | 25559 |
KEGGi | rno:25559 |
UCSCi | RGD:3786, rat [Q09429-1] |
Organism-specific databases
CTDi | 6833 |
RGDi | 3786, Abcc8 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000156626 |
HOGENOMi | CLU_000604_27_3_1 |
InParanoidi | Q09429 |
OMAi | FFWIGHY |
OrthoDBi | 138195at2759 |
PhylomeDBi | Q09429 |
Enzyme and pathway databases
Reactomei | R-RNO-1296025, ATP sensitive Potassium channels R-RNO-422356, Regulation of insulin secretion |
Miscellaneous databases
PROi | PR:Q09429 |
Gene expression databases
Bgeei | ENSRNOG00000021130, Expressed in cerebellum and 16 other tissues |
Genevisiblei | Q09429, RN |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR000844, ABCC8 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01093, SULFNYLUR1 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCC8_RAT | |
Accessioni | Q09429Primary (citable) accession number: Q09429 Secondary accession number(s): O54989, P70532, Q9EQT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families