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UniProtKB - Q09357 (MET16_CAEEL)

Entry version 136 (23 Feb 2022)
Sequence version 2 (11 Apr 2003)
Previous versions | rss
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Protein

U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

Gene

mett-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA N6-methyltransferase that methylates adenosine residues at the N6 position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289).

Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289).

Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:33930289).

In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289).

Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194).

Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194).

Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei82S-adenosyl-L-methionineBy similarity1
Binding sitei108S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei131S-adenosyl-L-methionineBy similarity1
Binding sitei164S-adenosyl-L-methionineBy similarity1
Binding sitei184S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q09357

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC:2.1.1.3461 Publication)
Alternative name(s):
N6-adenosine-methyltransferase mett-10Curated (EC:2.1.1.3481 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mett-101 PublicationImported
ORF Names:ZK1128.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...WormBasei		ZK1128.2a ; CE31860 ; WBGene00014228 ; mett-10
ZK1128.2b ; CE31861 ; WBGene00014228 ; mett-10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 260Missing in ok2204; at 25 degrees Celsius animals are either sterile or maternal-effect lethal, display a protruding vulva phenotype, and germ cells have abnormalities in meiotic development and mitotic progression; when associated with E-292. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background; when associated with E-292. 2 PublicationsAdd BLAST260
Mutagenesisi110G → R in oj32; at 25 degrees Celsius animals are either sterile or maternal-effect lethal and display a protruding vulva phenotype. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background. 2 Publications1
Mutagenesisi240 – 392Missing in tm2697; at 25 degrees Celsius animals are either sterile or maternal-effect lethal and display a protruding vulva phenotype. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background. 2 PublicationsAdd BLAST153
Mutagenesisi263G → D in g38; at 25 degrees Celsius animals are either sterile or maternal-effect lethal and display a protruding vulva phenotype. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background. 2 Publications1
Mutagenesisi276 – 479Missing in oz36; at 25 degrees Celsius animals are either sterile or maternal-effect lethal, display a protruding vulva phenotype, a distended intestinal lumen, tumor formation, and germ cells have abnormalities in meiotic development. Enhanced tumor formation in weak loss of function dhc-1 (or195) or dhc-1 (js319) mutant backgrounds. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background. 2 PublicationsAdd BLAST204
Mutagenesisi292G → E in ok2204; at 25 degrees Celsius animals are either sterile or maternal-effect lethal, display a protruding vulva phenotype, and germ cells have abnormalities in meiotic development and mitotic progression; when associated with 1-M--T-260 DEL. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background; when associated with 1-M--T-260 DEL. 2 Publications1
Mutagenesisi361 – 367Missing : Does not block nuclear entry. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with A-420; A-421; A-423 and A-424. 1 Publication7
Mutagenesisi420D → A: Abolishes binding to dlc-1. Reduces nuclear accumulation of mett-10; when associated with A-421; A-423 and A-424. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-421; A-423 and A-424. 1 Publication1
Mutagenesisi421N → A: Reduces binding to dlc-1. Abolishes binding to dlc-1, and reduces nuclear accumulation of mett-10; when associated with A-420; A-423 and A-424. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-420; A-423 and A-424. 1 Publication1
Mutagenesisi423S → A: Reduces binding to dlc-1. Abolishes binding to dlc-1, and reduces nuclear accumulation of mett-10; when associated with A-420; A-421 and A-424. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-420; A-421 and A-424. 1 Publication1
Mutagenesisi424Q → A: Reduces binding to dlc-1. Abolishes binding to dlc-1, and reduces nuclear accumulation of mett-10; when associated with A-420; A-421 and A-423. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-420; A-421 and A-423. 1 Publication1
Mutagenesisi426Y → A: Does not affect dlc-1 binding. 1 Publication1
Mutagenesisi427F → A: Does not affect dlc-1 binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002180211 – 479U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferaseAdd BLAST479

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q09357

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the intestine, vulva, and cells of the somatic gonad including distal tip cells, gonadal sheath cells and spermatheca.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00014228, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates (PubMed:19752194).

Interacts with dlc-1; the interaction is direct, and is required for nuclear localization of mett-10 (PubMed:19752194).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		56058, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q09357, 1 interactor

STRING: functional protein association networks

More...STRINGi		6239.ZK1128.2a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q09357

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni420 – 424Involved in dlc-1 binding1 Publication5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily. METTL16/RlmF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2912, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027534_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q09357

Identification of Orthologs from Complete Genome Data

More...OMAi		HWWIPDG

Database of Orthologous Groups

More...OrthoDBi		1358504at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q09357

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017182, METTL16/PsiM
IPR010286, METTL16/RlmF
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR13393, PTHR13393, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05971, Methyltransf_10, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037350, Mtase_ZK1128_prd, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q09357-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQNNEMHPR NPYRNKPPDF KALAVEYPEF RKFCQYVSNG KVTFDFKKDA 
        60         70         80         90        100
AVRCLTQTLL KKDFNLDVEI PPGHLVPRVP QKLNYCLLID DLLKANKLTK 
       110        120        130        140        150
NVIGIDIGTG TSCIHALIGA RQFNWKFIAT DGDEKSVRVA HENVAKNGLS 
       160        170        180        190        200
SSICVVHVNP DVKTVLMDVV NTIPDTDYAF CMCNPPFFEK GNGDDKFCED 
       210        220        230        240        250
ISSSTETYSN RVASEFRTAP HSATFASSAE LFVDGGEVAF VNRIIDDSVL 
       260        270        280        290        300
LRDRIKIYTT MIGRKSSLKP LQNRLQRFGD DVKIMISVLN QGKTKRWMLA 
       310        320        330        340        350
WTFSKSVSLT TIDRPISFQC PKPGLTRLMQ EISILNGRLR QEDTLAIVAE 
       360        370        380        390        400
FKCVTWTNQR ARKRAKAILS ESSIKKAKWN FSNVACQVAF GAGDGKDSYT 
       410        420        430        440        450
DAGNFVSSES IPTNNLNAWD NASQAYFPLP NGEVPGPIIR IRIQVFSEDS 
       460        470 
YDSISFELIS GSKQHLHQLV QYLKNLICR
Length:479
Mass (Da):53,805
Last modified:April 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i789AC9237A49BD7F
GO
Isoform bImported (identifier: Q09357-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-119: Missing.

Show »
Length:464
Mass (Da):52,352
Checksum:i7528BB54FB81B8AE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007120105 – 119Missing in isoform b. CuratedAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z47357 Genomic DNA Translation: CAA87421.2
Z47357 Genomic DNA Translation: CAD54175.1

Protein sequence database of the Protein Information Resource

More...PIRi		T27693

NCBI Reference Sequences

More...RefSeqi		NP_499247.2, NM_066846.4
NP_871660.1, NM_181931.6 [Q09357-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		ZK1128.2a.1; ZK1128.2a.1; WBGene00014228 [Q09357-1]
ZK1128.2b.1; ZK1128.2b.1; WBGene00014228 [Q09357-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		191526

UCSC genome browser

More...UCSCi		ZK1128.2b, c. elegans [Q09357-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47357 Genomic DNA Translation: CAA87421.2
Z47357 Genomic DNA Translation: CAD54175.1
PIRiT27693
RefSeqiNP_499247.2, NM_066846.4
NP_871660.1, NM_181931.6 [Q09357-2]

3D structure databases

SMRiQ09357
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi56058, 7 interactors
IntActiQ09357, 1 interactor
STRINGi6239.ZK1128.2a

Proteomic databases

PaxDbiQ09357

Genome annotation databases

EnsemblMetazoaiZK1128.2a.1; ZK1128.2a.1; WBGene00014228 [Q09357-1]
ZK1128.2b.1; ZK1128.2b.1; WBGene00014228 [Q09357-2]
GeneIDi191526
UCSCiZK1128.2b, c. elegans [Q09357-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		191526
WormBaseiZK1128.2a ; CE31860 ; WBGene00014228 ; mett-10
ZK1128.2b ; CE31861 ; WBGene00014228 ; mett-10

Phylogenomic databases

eggNOGiKOG2912, Eukaryota
GeneTreeiENSGT00390000016694
HOGENOMiCLU_027534_0_0_1
InParanoidiQ09357
OMAiHWWIPDG
OrthoDBi1358504at2759
PhylomeDBiQ09357

Enzyme and pathway databases

SignaLinkiQ09357

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q09357

Gene expression databases

BgeeiWBGene00014228, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR017182, METTL16/PsiM
IPR010286, METTL16/RlmF
IPR029063, SAM-dependent_MTases
PANTHERiPTHR13393, PTHR13393, 1 hit
PfamiView protein in Pfam
PF05971, Methyltransf_10, 1 hit
PIRSFiPIRSF037350, Mtase_ZK1128_prd, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMET16_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09357
Secondary accession number(s): Q8I4B2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 11, 2003
Last modified: February 23, 2022
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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