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Entry version 121 (02 Jun 2021)
Sequence version 3 (20 Jun 2003)
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Protein

Sentrin-specific protease

Gene

ulp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei585By similarity1
Active sitei602By similarity1
Active sitei653By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3065679, SUMO is proteolytically processed
R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C48.A15

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sentrin-specific protease (EC:3.4.22.-)
Alternative name(s):
SUMO protease
Short name:
SuPr
Ubiquitin-like protease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ulp-1
ORF Names:T10F2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
T10F2.3 ; CE33694 ; WBGene00006736 ; ulp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes increased presence of smo-1 conjugates during the first embryonic mitotic division.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017301 – 697Sentrin-specific proteaseAdd BLAST697

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q09353

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09353

PeptideAtlas

More...
PeptideAtlasi
Q09353

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q09353

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006736, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
40935, 7 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T10F2.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09353

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni365 – 387DisorderedSequence analysisAdd BLAST23
Regioni501 – 664ProteaseAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi15 – 19Nuclear localization signalSequence analysis5
Motifi462 – 467Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 38Basic and acidic residuesSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0778, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167730

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_415183_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09353

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRFTQKN

Database of Orthologous Groups

More...
OrthoDBi
905030at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02902, Peptidase_C48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09353-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRSDLSDK DSQSRKRHWL TDQAVTNEEK EQSPTKRTRK TKSQGLGGLF
60 70 80 90 100
NTFFGMFVSS NSGEKEKTEV SGEVQVQEDD EIIVEGTTRR VAENKKYMIF
110 120 130 140 150
LNEDAPVRAN AGSEENEVII EKHVQKNVEI RNDEEKQEVQ GDLVLTLSSS
160 170 180 190 200
PKSPKNLEKS FEVQQDDEEP DVLFEKVVKT PNKQLQEARR FQNELIFLND
210 220 230 240 250
NPDTPDDVSV ISDSRSKEFI SPTPDDSVSR PITPSLSSLS NYTSNNVRDY
260 270 280 290 300
WRRNSAKKPE VLRRVPVRHQ FKHSTSVRKM NTIIDLKKIK NHLSSRDRLL
310 320 330 340 350
QGVVASGQYE AKAISGIVEK KPKKMQRTSS TDILARAKNK IAELGGSRSN
360 370 380 390 400
TPSLLSREPS IIIDSEESTS SSYRQHARSN SSESDSYRKL NDILSQINSL
410 420 430 440 450
GIGSAYRGPQ RYQNSYQLSK QKEDKLLEEA RIREGHRSQT RGDRLEDVRK
460 470 480 490 500
RLELQGIAIR PKVEKKKVDD FMALPDAADA LVERAWSGGN PNEQFVDAFS
510 520 530 540 550
IQICKKDLAT LSGLHWLNDE IINFYLQLIC DRSNGDSKYP KIYAFNTFFY
560 570 580 590 600
SNIVSKGYAS VKRWTRKVDI FAFDIVLVPV HLGMHWCMAV IDMGEKKIEF
610 620 630 640 650
YDSLYDGNTA VLPALRGYLE AESLDKKKTA MNFSGWTIQQ MTDIPRQQNG
660 670 680 690
SDCGVFSCQF GEWASRRTTP RFTQKNMPYY RKRMVYEIVS KKLLATI
Length:697
Mass (Da):79,647
Last modified:June 20, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE825B031779E3B04
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB095020 mRNA Translation: BAC22612.1
FO081619 Genomic DNA Translation: CCD72868.1

NCBI Reference Sequences

More...
RefSeqi
NP_498095.3, NM_065694.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T10F2.3.1; T10F2.3.1; WBGene00006736

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175704

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T10F2.3

UCSC genome browser

More...
UCSCi
T10F2.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095020 mRNA Translation: BAC22612.1
FO081619 Genomic DNA Translation: CCD72868.1
RefSeqiNP_498095.3, NM_065694.6

3D structure databases

SMRiQ09353
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi40935, 7 interactors
STRINGi6239.T10F2.3

Protein family/group databases

MEROPSiC48.A15

PTM databases

iPTMnetiQ09353

Proteomic databases

EPDiQ09353
PaxDbiQ09353
PeptideAtlasiQ09353

Genome annotation databases

EnsemblMetazoaiT10F2.3.1; T10F2.3.1; WBGene00006736
GeneIDi175704
KEGGicel:CELE_T10F2.3
UCSCiT10F2.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175704
WormBaseiT10F2.3 ; CE33694 ; WBGene00006736 ; ulp-1

Phylogenomic databases

eggNOGiKOG0778, Eukaryota
GeneTreeiENSGT00940000167730
HOGENOMiCLU_415183_0_0_1
InParanoidiQ09353
OMAiPRFTQKN
OrthoDBi905030at2759

Enzyme and pathway databases

ReactomeiR-CEL-3065679, SUMO is proteolytically processed
R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09353

Gene expression databases

BgeeiWBGene00006736, Expressed in adult organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C
PfamiView protein in Pfam
PF02902, Peptidase_C48, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSENP_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09353
Secondary accession number(s): Q8IU18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 20, 2003
Last modified: June 2, 2021
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families
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