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Entry version 156 (18 Sep 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

Gene

MGAT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033).By similarity3 Publications
Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is increased by Mn2+ and Mg2+.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6.78 mM for GlcNAc1 Publication
  2. KM=5.8 mM for GlcNAc1 Publication

    pH dependencei

    Optimum pH is 6.5.1 Publication

    Temperature dependencei

    Optimum temperature is 50 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.3 Publications
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei526UDP-GlcNAc1 Publication1
    Binding sitei554Substrate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS07793-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.1.155 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-975577 N-Glycan antennae elongation

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT18 Glycosyltransferase Family 18

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC:2.4.1.1552 Publications)
    Alternative name(s):
    Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V1 Publication
    GlcNAc-T V1 Publication
    Short name:
    GNT-V
    Mannoside acetylglucosaminyltransferase 5
    N-acetylglucosaminyl-transferase V
    Cleaved into the following chain:
    Alternative name(s):
    Secreted beta-1,6-N-acetylglucosaminyltransferase V1 Publication
    Short name:
    Secreted GNT-V1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MGAT5
    Synonyms:GGNT5
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:7049 MGAT5

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    601774 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q09328

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
    Topological domaini31 – 741Lumenal1 PublicationAdd BLAST711

    Keywords - Cellular componenti

    Golgi apparatus, Membrane, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29L → D: No effect on the biosynthesis of the secreted form. 1 Publication1
    Mutagenesisi30L → D: No effect on the biosynthesis of the secreted form. 1 Publication1
    Mutagenesisi31H → A: No effect on the biosynthesis of the secreted form. 1 Publication1
    Mutagenesisi280E → A: Decreased catalytic activity. 1 Publication1
    Mutagenesisi287E → A: Decreased catalytic activity. 1 Publication1
    Mutagenesisi297E → A: Loss of catalytic activity. 1 Publication1
    Mutagenesisi429E → A: Decreased catalytic activity. 1 Publication1
    Mutagenesisi520E → A: Loss of catalytic activity. 1 Publication1
    Mutagenesisi526E → A: Loss of catalytic activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4249

    Open Targets

    More...
    OpenTargetsi
    ENSG00000152127

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30784

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1795131

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MGAT5

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    1169980

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805221 – 741Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase AAdd BLAST741
    ChainiPRO_000044569231 – 741Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase ACuratedAdd BLAST711

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi145 ↔ 183Combined sources1 Publication
    Disulfide bondi156 ↔ 196Combined sources1 Publication
    Disulfide bondi172 ↔ 338Combined sources1 Publication
    Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi372 ↔ 626Combined sources1 Publication
    Glycosylationi433N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi649 ↔ 724Combined sources1 Publication
    Disulfide bondi653 ↔ 726Combined sources1 Publication
    Disulfide bondi660 ↔ 713Combined sources1 Publication
    Disulfide bondi681 ↔ 702Combined sources1 Publication
    Disulfide bondi737 ↔ 740Combined sources1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.3 Publications
    A secreted form is released from the membrane after cleavage by gamma-secretase.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q09328

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q09328

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q09328

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q09328

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q09328

    PeptideAtlas

    More...
    PeptideAtlasi
    Q09328

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q09328

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    58719

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q09328

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q09328

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Induced by IFNG treatment in monocytes (in vitro).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000152127 Expressed in 223 organ(s), highest expression level in metanephric glomerulus

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q09328 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA010919

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    110405, 25 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q09328

    Protein interaction database and analysis system

    More...
    IntActi
    Q09328, 16 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000386377

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1741
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q09328

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni213 – 741Sufficient for catalytic activity1 PublicationAdd BLAST529
    Regioni264 – 269Important for activity in FGF2 release1 Publication6
    Regioni378 – 379Substrate binding1 Publication2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 18 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IDYS Eukaryota
    ENOG410XTV7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153470

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000006557

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q09328

    KEGG Orthology (KO)

    More...
    KOi
    K00744

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ENWCPRL

    Database of Orthologous Groups

    More...
    OrthoDBi
    179031at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q09328

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313714

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR027833 DUF4525
    IPR026116 GlyclTrfase_18

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF15027 DUF4525, 1 hit
    PF15024 Glyco_transf_18, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09328-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MALFTPWKLS SQKLGFFLVT FGFIWGMMLL HFTIQQRTQP ESSSMLREQI
    60 70 80 90 100
    LDLSKRYIKA LAEENRNVVD GPYAGVMTAY DLKKTLAVLL DNILQRIGKL
    110 120 130 140 150
    ESKVDNLVVN GTGTNSTNST TAVPSLVALE KINVADIING AQEKCVLPPM
    160 170 180 190 200
    DGYPHCEGKI KWMKDMWRSD PCYADYGVDG STCSFFIYLS EVENWCPHLP
    210 220 230 240 250
    WRAKNPYEEA DHNSLAEIRT DFNILYSMMK KHEEFRWMRL RIRRMADAWI
    260 270 280 290 300
    QAIKSLAEKQ NLEKRKRKKV LVHLGLLTKE SGFKIAETAF SGGPLGELVQ
    310 320 330 340 350
    WSDLITSLYL LGHDIRISAS LAELKEIMKK VVGNRSGCPT VGDRIVELIY
    360 370 380 390 400
    IDIVGLAQFK KTLGPSWVHY QCMLRVLDSF GTEPEFNHAN YAQSKGHKTP
    410 420 430 440 450
    WGKWNLNPQQ FYTMFPHTPD NSFLGFVVEQ HLNSSDIHHI NEIKRQNQSL
    460 470 480 490 500
    VYGKVDSFWK NKKIYLDIIH TYMEVHATVY GSSTKNIPSY VKNHGILSGR
    510 520 530 540 550
    DLQFLLRETK LFVGLGFPYE GPAPLEAIAN GCAFLNPKFN PPKSSKNTDF
    560 570 580 590 600
    FIGKPTLREL TSQHPYAEVF IGRPHVWTVD LNNQEEVEDA VKAILNQKIE
    610 620 630 640 650
    PYMPYEFTCE GMLQRINAFI EKQDFCHGQV MWPPLSALQV KLAEPGQSCK
    660 670 680 690 700
    QVCQESQLIC EPSFFQHLNK DKDMLKYKVT CQSSELAKDI LVPSFDPKNK
    710 720 730 740
    HCVFQGDLLL FSCAGAHPRH QRVCPCRDFI KGQVALCKDC L
    Length:741
    Mass (Da):84,543
    Last modified:November 1, 1995 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1073F8E67AD0E23B
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D17716 mRNA Translation: BAA04570.1
    AF113921 mRNA Translation: AAD22449.1
    CH471058 Genomic DNA Translation: EAX11657.1
    CH471058 Genomic DNA Translation: EAX11658.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2171.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JC2074

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_002401.1, NM_002410.4
    XP_005263725.1, XM_005263668.4
    XP_005263726.1, XM_005263669.4
    XP_005263727.1, XM_005263670.3
    XP_006712597.1, XM_006712534.3
    XP_011509501.1, XM_011511199.2
    XP_011509502.1, XM_011511200.1
    XP_011509503.1, XM_011511201.2
    XP_011509504.1, XM_011511202.1
    XP_016859636.1, XM_017004147.1
    XP_016859637.1, XM_017004148.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000281923; ENSP00000281923; ENSG00000152127
    ENST00000409645; ENSP00000386377; ENSG00000152127

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    4249

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4249

    UCSC genome browser

    More...
    UCSCi
    uc002ttw.5 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Functional Glycomics Gateway - GTase

    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferaseV

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D17716 mRNA Translation: BAA04570.1
    AF113921 mRNA Translation: AAD22449.1
    CH471058 Genomic DNA Translation: EAX11657.1
    CH471058 Genomic DNA Translation: EAX11658.1
    CCDSiCCDS2171.1
    PIRiJC2074
    RefSeqiNP_002401.1, NM_002410.4
    XP_005263725.1, XM_005263668.4
    XP_005263726.1, XM_005263669.4
    XP_005263727.1, XM_005263670.3
    XP_006712597.1, XM_006712534.3
    XP_011509501.1, XM_011511199.2
    XP_011509502.1, XM_011511200.1
    XP_011509503.1, XM_011511201.2
    XP_011509504.1, XM_011511202.1
    XP_016859636.1, XM_017004147.1
    XP_016859637.1, XM_017004148.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5ZIBX-ray1.90A121-741[»]
    5ZICX-ray2.10A/B213-329[»]
    A/B345-741[»]
    SMRiQ09328
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi110405, 25 interactors
    CORUMiQ09328
    IntActiQ09328, 16 interactors
    STRINGi9606.ENSP00000386377

    Chemistry databases

    ChEMBLiCHEMBL1795131

    Protein family/group databases

    CAZyiGT18 Glycosyltransferase Family 18

    PTM databases

    iPTMnetiQ09328
    PhosphoSitePlusiQ09328

    Polymorphism and mutation databases

    BioMutaiMGAT5
    DMDMi1169980

    Proteomic databases

    EPDiQ09328
    jPOSTiQ09328
    MassIVEiQ09328
    MaxQBiQ09328
    PaxDbiQ09328
    PeptideAtlasiQ09328
    PRIDEiQ09328
    ProteomicsDBi58719

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    4249
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000281923; ENSP00000281923; ENSG00000152127
    ENST00000409645; ENSP00000386377; ENSG00000152127
    GeneIDi4249
    KEGGihsa:4249
    UCSCiuc002ttw.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4249
    DisGeNETi4249

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MGAT5
    HGNCiHGNC:7049 MGAT5
    HPAiHPA010919
    MIMi601774 gene
    neXtProtiNX_Q09328
    OpenTargetsiENSG00000152127
    PharmGKBiPA30784

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410IDYS Eukaryota
    ENOG410XTV7 LUCA
    GeneTreeiENSGT00940000153470
    HOGENOMiHOG000006557
    InParanoidiQ09328
    KOiK00744
    OMAiENWCPRL
    OrthoDBi179031at2759
    PhylomeDBiQ09328
    TreeFamiTF313714

    Enzyme and pathway databases

    UniPathwayiUPA00378
    BioCyciMetaCyc:HS07793-MONOMER
    BRENDAi2.4.1.155 2681
    ReactomeiR-HSA-975577 N-Glycan antennae elongation

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    MGAT5 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    MGAT5

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4249

    Pharos

    More...
    Pharosi
    Q09328

    Protein Ontology

    More...
    PROi
    PR:Q09328

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000152127 Expressed in 223 organ(s), highest expression level in metanephric glomerulus
    GenevisibleiQ09328 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR027833 DUF4525
    IPR026116 GlyclTrfase_18
    PfamiView protein in Pfam
    PF15027 DUF4525, 1 hit
    PF15024 Glyco_transf_18, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGT5A_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09328
    Secondary accession number(s): D3DP70
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: September 18, 2019
    This is version 156 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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