Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytosolic carboxypeptidase 6

Gene

ccpp-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates tubulin deglutamylation in sensory cilia. Catalyzes the removing polyglutamate side chains that are present on the gamma-carboxyl group of glutamate residues of tubulin in sensory cilia.2 Publications

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi204ZincBy similarity1
Metal bindingi207ZincBy similarity1
Active sitei254NucleophileBy similarity1
Metal bindingi302ZincBy similarity1

GO - Molecular functioni

  • metallocarboxypeptidase activity Source: WormBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • oviposition Source: WormBase
  • protein deglutamylation Source: UniProtKB
  • proteolysis Source: WormBase

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM14.A31

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase 6 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 4 homolog
Short name:
CeAGBL4
Gene namesi
Name:ccpp-6
ORF Names:EEED8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiEEED8.6 ; CE40199 ; WBGene00017136 ; ccpp-6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000652721 – 459Cytosolic carboxypeptidase 6Add BLAST459

Proteomic databases

PaxDbiQ09296
PRIDEiQ09296

Expressioni

Tissue specificityi

Expressed in labial and amphid neurons.1 Publication

Gene expression databases

BgeeiWBGene00017136 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

BioGridi48845, 1 interactor
DIPiDIP-26727N
STRINGi6239.EEED8.6

Structurei

3D structure databases

ProteinModelPortaliQ09296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiKOG3641 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00550000074405
HOGENOMiHOG000231164
InParanoidiQ09296
OMAiKWQRIPR
OrthoDBiEOG091G0FXK
PhylomeDBiQ09296

Family and domain databases

InterProiView protein in InterPro
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit

Sequencei

Sequence statusi: Complete.

Q09296-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGYVGNVSYP DTIPGQGNLV FEASFESGNL GRVDKVSCSE YDLFIRPDTL
60 70 80 90 100
NNKYRVWFYF ECKNASENQR AIFNIVNFSK QRTLFEMGIA APVVKSNAQN
110 120 130 140 150
SWARIPSRHI YYYRSSQHND RWILSFAFIF ESPDPVQFAY CIPYTYGQMQ
160 170 180 190 200
IWLNELESRK YPFFHRDLLV QTVQKRRVDL ITIDATPDTF QGSKKMIFLT
210 220 230 240 250
ARVHPGESPS SHVMHGIIEF LVSKDDRAQK LRKVYCFKII PMLNPDGVFL
260 270 280 290 300
GNYRCSLMGH DLNRMWRTPS DWAHPSIYAV KNLLTQYDNN PQAQTVIYVD
310 320 330 340 350
LHAHSQKPNC FLYGNVNMSA VEEKSTFRQL WLPHLLADLS EDYSLEFTQF
360 370 380 390 400
NTDVEKAGTG RRTMGDLLSC LCYTLEVSFF SYRHTDSSGN GIQHCTPYLQ
410 420 430 440 450
YKYEALGEAF CRALLNFYEA DCGLREIVLE RPFKTFLPAR AQKTLKKQAR

KVIQTVMMK
Length:459
Mass (Da):53,241
Last modified:September 5, 2006 - v2
Checksum:i493371030E293619
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081042 Genomic DNA Translation: CCD68733.1
PIRiT15916
RefSeqiNP_495012.2, NM_062611.2
UniGeneiCel.15545

Genome annotation databases

EnsemblMetazoaiEEED8.6; EEED8.6; WBGene00017136
GeneIDi184043
KEGGicel:CELE_EEED8.6
UCSCiEEED8.6 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081042 Genomic DNA Translation: CCD68733.1
PIRiT15916
RefSeqiNP_495012.2, NM_062611.2
UniGeneiCel.15545

3D structure databases

ProteinModelPortaliQ09296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi48845, 1 interactor
DIPiDIP-26727N
STRINGi6239.EEED8.6

Protein family/group databases

MEROPSiM14.A31

Proteomic databases

PaxDbiQ09296
PRIDEiQ09296

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEEED8.6; EEED8.6; WBGene00017136
GeneIDi184043
KEGGicel:CELE_EEED8.6
UCSCiEEED8.6 c. elegans

Organism-specific databases

CTDi184043
WormBaseiEEED8.6 ; CE40199 ; WBGene00017136 ; ccpp-6

Phylogenomic databases

eggNOGiKOG3641 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00550000074405
HOGENOMiHOG000231164
InParanoidiQ09296
OMAiKWQRIPR
OrthoDBiEOG091G0FXK
PhylomeDBiQ09296

Miscellaneous databases

PROiPR:Q09296

Gene expression databases

BgeeiWBGene00017136 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBPC6_CAEEL
AccessioniPrimary (citable) accession number: Q09296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again