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Entry version 91 (08 May 2019)
Sequence version 2 (25 Apr 2018)
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Protein

E3 ubiquitin-protein ligase hecw-1

Gene

hecw-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase (By similarity). Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours (PubMed:22089131). Likely to act by inhibiting the neuropeptide receptor npr-1 (PubMed:22089131).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1215Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-4641258 Degradation of DVL
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase hecw-1Curated (EC:2.3.2.26By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hecw-11 PublicationImported
ORF Names:F45H7.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
F45H7.6a ; CE44269 ; WBGene00009738 ; hecw-1
F45H7.6b ; CE51746 ; WBGene00009738 ; hecw-1
F45H7.6c ; CE01532 ; WBGene00009738 ; hecw-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000652581 – 1247E3 ubiquitin-protein ligase hecw-1Add BLAST1247

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09291

PeptideAtlas

More...
PeptideAtlasi
Q09291

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the nervous system throughout the body. In the anterior ganglion, expression is limited to the two lateral outer labial neurons OLLL and OLLR.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008347 Expressed in 3 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F45H7.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q09291

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini602 – 635WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini745 – 777WW 2PROSITE-ProRule annotationAdd BLAST33
Domaini914 – 1247HECTPROSITE-ProRule annotationAdd BLAST334

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K90C Eukaryota
KOG0940 Eukaryota
COG5021 LUCA
ENOG4110JUA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173012

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09291

Identification of Orthologs from Complete Genome Data

More...
OMAi
KETRWTK

Database of Orthologous Groups

More...
OrthoDBi
25515at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09291

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit
cd00201 WW, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012885 F-box-assoc_dom_typ2
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR040524 HECW1_helix
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07735 FBA_2, 1 hit
PF00632 HECT, 1 hit
PF18436 HECW1_helix, 1 hit
PF00397 WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 2 hits
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform bImported (identifier: Q09291-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDEFPFHHL GYVCLNEIYK HLTLKEIFQL SFSSNQIKRS LGIASIPVKS
60 70 80 90 100
IFVNFDSQYP KIKLIGESSQ LEWVFGIPDG LEYTDVGVYK IGHFKFQCKT
110 120 130 140 150
SGTAFYTEHY DLENAMLVVI RYMISIFKCS NSIITYLSID LGVIEDSRAI
160 170 180 190 200
CENFVAFKKV ERLSIFQTNY GVERNTLNFA QSFDWICDNL EIKNIHIGAD
210 220 230 240 250
VLEPKMVQKT NGEFDIKLCA RRFEQVLTMD HIYLQHADWI TSEDLLNLDV
260 270 280 290 300
QTAMLIENNL TEQDLNAFIK QWLRSDSDKL WWLEVKGKMM FNREEVLKDL
310 320 330 340 350
DVQDDAYRSL NTRWYVARRS RANPSGNGCA RKKMGSLRPK LTELWPFKVY
360 370 380 390 400
IIFGSILIVF GPAALNRMIT LRRMDVETDR PSGSETGIFV SKSAVYPFGN
410 420 430 440 450
KNEVVKVWWN IDKPENCLDW IGLFDNNDSS FYLDQKSLRQ HISPVVFTLT
460 470 480 490 500
SKNLLNASEV YFGLIDGMTG RLLAKSENVE ICKSASLVVH EVKKPENINV
510 520 530 540 550
YLNTNHGRIE IPKKRSFSRK NGSFRSSFEF DFDVEDLHIS LVENSEKLNF
560 570 580 590 600
DHFIASNQLQ NNYIQSKSFS HSHVVEIVFS IEPKTSKKSA PDIMEIASSS
610 620 630 640 650
QTPPESHWKT YLDAKKRKFY VNHVTKETRW TKPDTLNNNH IEPETPVHKR
660 670 680 690 700
LSDRSASPRN SFITPRRTIT VRSAGCPKSD LIQFFQRDEF KTALYENQDA
710 720 730 740 750
MQIYNECSVV RHAIHRIQKD LDPPSKFENQ PLFVRFVNLF ADITQPLPSG
760 770 780 790 800
WECITMNNRT VFLNHANKET SFYDPRIRRF ETKTSRRGRS VPSRSSTAHK
810 820 830 840 850
GKIDHALISK CEDLRKIAQD NFPQIAERIS KKLMLIERFG GLAVASLAND
860 870 880 890 900
LDITLALSML DSNTEKLAGE GDNIKMFYED MKKEKLGKGP SRLCWKVSRD
910 920 930 940 950
RLLDDAFRII LNVDPFVLKK SRLHIRFEGE LALDYGGLSR EFFILLSREL
960 970 980 990 1000
FHPKNGYFEY EGNDYHLQLR PRGCETEKEK KWLILCGRVL ALAVIHRCYI
1010 1020 1030 1040 1050
DVFFTNVFYK SLQKRPVTLM DFKESDAEFY KSMNWLLEND VVDLEMSFVY
1060 1070 1080 1090 1100
SSMVNGKLAE QELVPGGESQ MVTEANKAEF IDLMCQKKAI RGVEKPLEIL
1110 1120 1130 1140 1150
LTSFNQILND NLLNSLESSD LKRILSGSLE LDLNDWRTNT IYKGGYSDCH
1160 1170 1180 1190 1200
IVVEWFWEVI ETMTNQERFD LLLFVTGSSS VPFEGFSALR GNEEISKFCI
1210 1220 1230 1240
EKWGDATSFP RAHTCFNRLQ LPSYNTKQQL KSKLQQAIVN GMSYSIE
Length:1,247
Mass (Da):144,050
Last modified:April 25, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47AAECB3C04FC738
GO
Isoform aImported (identifier: Q09291-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-373: Missing.

Show »
Length:874
Mass (Da):100,720
Checksum:i9000421ED660F589
GO
Isoform cImported (identifier: Q09291-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-1247: Missing.

Show »
Length:367
Mass (Da):42,577
Checksum:i31E7C8DDD94C9274
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0595361 – 373Missing in isoform a. CuratedAdd BLAST373
Alternative sequenceiVSP_059537368 – 1247Missing in isoform c. CuratedAdd BLAST880

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA84325.2
BX284603 Genomic DNA Translation: CAA86770.1
BX284603 Genomic DNA Translation: SBV53365.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20271

NCBI Reference Sequences

More...
RefSeqi
NP_001317872.1, NM_001330981.1 [Q09291-1]
NP_497697.2, NM_065296.3 [Q09291-2]
NP_497698.1, NM_065297.1 [Q09291-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F45H7.6a; F45H7.6a; WBGene00009738 [Q09291-2]
F45H7.6b; F45H7.6b; WBGene00009738 [Q09291-1]
F45H7.6c; F45H7.6c; WBGene00009738 [Q09291-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175438

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F45H7.6

UCSC genome browser

More...
UCSCi
C56G7.2 c. elegans [Q09291-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA84325.2
BX284603 Genomic DNA Translation: CAA86770.1
BX284603 Genomic DNA Translation: SBV53365.1
PIRiT20271
RefSeqiNP_001317872.1, NM_001330981.1 [Q09291-1]
NP_497697.2, NM_065296.3 [Q09291-2]
NP_497698.1, NM_065297.1 [Q09291-3]

3D structure databases

SMRiQ09291
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F45H7.6

Proteomic databases

PaxDbiQ09291
PeptideAtlasiQ09291

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF45H7.6a; F45H7.6a; WBGene00009738 [Q09291-2]
F45H7.6b; F45H7.6b; WBGene00009738 [Q09291-1]
F45H7.6c; F45H7.6c; WBGene00009738 [Q09291-3]
GeneIDi175438
KEGGicel:CELE_F45H7.6
UCSCiC56G7.2 c. elegans [Q09291-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175438
WormBaseiF45H7.6a ; CE44269 ; WBGene00009738 ; hecw-1
F45H7.6b ; CE51746 ; WBGene00009738 ; hecw-1
F45H7.6c ; CE01532 ; WBGene00009738 ; hecw-1

Phylogenomic databases

eggNOGiENOG410K90C Eukaryota
KOG0940 Eukaryota
COG5021 LUCA
ENOG4110JUA LUCA
GeneTreeiENSGT00940000173012
InParanoidiQ09291
OMAiKETRWTK
OrthoDBi25515at2759
PhylomeDBiQ09291

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-CEL-4641258 Degradation of DVL
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q09291

Gene expression databases

BgeeiWBGene00008347 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd00201 WW, 2 hits
InterProiView protein in InterPro
IPR012885 F-box-assoc_dom_typ2
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR040524 HECW1_helix
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF07735 FBA_2, 1 hit
PF00632 HECT, 1 hit
PF18436 HECW1_helix, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHECW1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09291
Secondary accession number(s): A0A1C3NSJ1, G5EEJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 25, 2018
Last modified: May 8, 2019
This is version 91 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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