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Protein

Proteasomal ubiquitin receptor ADRM1 homolog

Gene

rpn-13

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasomal ubiquitin receptor ADRM1 homologCurated
Alternative name(s):
Proteasome non-ATPase regulatory particle-like protein 13Imported
Gene namesi
Name:rpn-13Imported
ORF Names:C56G2.7Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC56G2.7 ; CE30640 ; WBGene00016981 ; rpn-13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000652571 – 374Proteasomal ubiquitin receptor ADRM1 homologAdd BLAST374

Proteomic databases

EPDiQ09289
PaxDbiQ09289
PeptideAtlasiQ09289
PRIDEiQ09289

PTM databases

iPTMnetiQ09289

Expressioni

Gene expression databases

BgeeiWBGene00016981 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex (By similarity). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). Interacts with deubiquitinase ubh-4 (PubMed:23770237).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi533206, 1 interactor
IntActiQ09289, 5 interactors
STRINGi6239.C56G2.7.1

Structurei

3D structure databases

ProteinModelPortaliQ09289
SMRiQ09289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 130Pru (pleckstrin-like receptor for ubiquitin) domainBy similarityAdd BLAST114

Domaini

The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with rpn-2 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows ubh-4 access to the distal subunit.By similarity

Sequence similaritiesi

Belongs to the ADRM1 family.Curated

Phylogenomic databases

eggNOGiKOG3037 Eukaryota
ENOG410XSJJ LUCA
GeneTreeiENSGT00390000013839
HOGENOMiHOG000005947
InParanoidiQ09289
KOiK06691
OMAiHCRRINE
OrthoDBiEOG091G0FEO
PhylomeDBiQ09289

Family and domain databases

Gene3Di2.30.29.70, 1 hit
3.40.190.140, 1 hit
InterProiView protein in InterPro
IPR006773 Rpn13/ADRM1
IPR038633 Rpn13/ADRM1_sf
IPR032368 RPN13_C
IPR038108 RPN13_C_sf
PANTHERiPTHR12225 PTHR12225, 1 hit
PfamiView protein in Pfam
PF04683 Proteasom_Rpn13, 1 hit
PF16550 RPN13_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q09289-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAMFSNTRS VASSSGHIVE FKAGRSRLEA GSGDTMRKVV AEPKKGLVFI
60 70 80 90 100
KQSNDMLIHF CWKDRETGAV VDDLIIFPDD AEFKAVPGCP DGKVYMLKFK
110 120 130 140 150
SGDMKLFWIQ DSTPDVDKDL VKKVTDALNK PPTSRPAASR SAGSNANTDR
160 170 180 190 200
QSAGGSLISS SDMNAPLGGI DQGQLMSLIQ SLQGGNSDTL PISSVPRGED
210 220 230 240 250
ASSEADCEPS TNAAEEGSSN PLSLNNPAIQ QIFNNLGRSQ KKEVAVSLAT
260 270 280 290 300
ALSNETVAEV ARNHAEELAP HLPTSDDPAR ELSETVRTPQ FRQAADTLGH
310 320 330 340 350
ALQTGQLGPV VAQFGMDEAT VGSANQGDIR GFAANLTKAE GGEDAAKTQN
360 370
SDDDATREPE PKRNRPDNED MDVD
Length:374
Mass (Da):39,773
Last modified:June 20, 2002 - v2
Checksum:iFD37CFC6EB991044
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5ATW5A0A2K5ATW5_CAEEL
Proteasomal ubiquitin receptor ADRM...
rpn-13 C56G2.7, CELE_C56G2.7
406Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD66338.1
RefSeqiNP_498387.2, NM_065986.6
UniGeneiCel.20046

Genome annotation databases

EnsemblMetazoaiC56G2.7; C56G2.7; WBGene00016981
GeneIDi3565888
KEGGicel:CELE_C56G2.7
UCSCiC56G2.7 c. elegans

Similar proteinsi

Entry informationi

Entry nameiADRM1_CAEEL
AccessioniPrimary (citable) accession number: Q09289
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 20, 2002
Last modified: September 12, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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