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Protein

Glyoxalase 1

Gene

glod-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thought to act as a glyoxalase. May remove methylglyoxal from mitochondrial proteins. Has roles in reducing oxidative stress and increasing lifespan.1 Publication

GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • methylglyoxal metabolic process Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxalase 1
Short name:
CeGly
Alternative name(s):
Glyoxalase domain-containing protein 4
Gene namesi
Name:glod-4
Synonyms:tag-73
ORF Names:C16C10.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC16C10.10 ; CE01490 ; WBGene00006448 ; glod-4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000651841 – 281Glyoxalase 1Add BLAST281

Proteomic databases

EPDiQ09253
PaxDbiQ09253
PeptideAtlasiQ09253
PRIDEiQ09253

Expressioni

Tissue specificityi

Expressed in the following tissues in both larvae and adults: pharynx, pharyngeal-intestinal valve, intestine, anal sphincter, vulval muscle, seam cells and the nervous system.1 Publication

Developmental stagei

Expression increases from day 1 to day 12 but activity decreased 10-fold during this period indicating that post translational modification is operational.

Gene expression databases

BgeeiWBGene00006448

Interactioni

Protein-protein interaction databases

STRINGi6239.C16C10.10

Structurei

3D structure databases

ProteinModelPortaliQ09253
SMRiQ09253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 127VOC 1PROSITE-ProRule annotationAdd BLAST124
Domaini132 – 251VOC 2PROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2943 Eukaryota
COG0346 LUCA
GeneTreeiENSGT00390000012340
HOGENOMiHOG000006776
InParanoidiQ09253
OMAiCEAACNG
OrthoDBiEOG091G0EHY
PhylomeDBiQ09253

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 2 hits
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequencei

Sequence statusi: Complete.

Q09253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARALHYVF KVANRAKTID FFTNVLNMKV LRHEEFEKGC EATCNGPYNG
60 70 80 90 100
RWSKTMIGYG SEDEHFVLEI TYNYPIHKYE LGNDYRAIVI DSDQLFEKVE
110 120 130 140 150
KINHRKSGCG RLAVKDPDGH EFKIGKADQS PKVLRVQVNV GDLEKSKKYW
160 170 180 190 200
NETLGMPIVE EKSSRIRMSY GDGQCELEIV KSQDKIDRKT GFGRIAFSYP
210 220 230 240 250
EDKLESLQDK IKSANGTIIN ELTTLETPGK ADVQVVILAD PDEHEICFVG
260 270 280
DEGFRALSKI DDKAESELKE QIKKDDSEKW I
Length:281
Mass (Da):32,093
Last modified:November 1, 1997 - v1
Checksum:iD32D2A9573EA517B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46787 Genomic DNA Translation: CAA86748.1
PIRiT19331
RefSeqiNP_497827.1, NM_065426.1
UniGeneiCel.10826

Genome annotation databases

EnsemblMetazoaiC16C10.10; C16C10.10; WBGene00006448
GeneIDi175530
KEGGicel:CELE_C16C10.10

Similar proteinsi

Entry informationi

Entry nameiGLOD4_CAEEL
AccessioniPrimary (citable) accession number: Q09253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 20, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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