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Protein

RING finger protein 121

Gene

rnf-121

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 358RING-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: WormBase

GO - Biological processi

  • endoplasmic reticulum unfolded protein response Source: WormBase
  • inductive cell migration Source: WormBase
  • ubiquitin-dependent ERAD pathway Source: WormBase

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 121
Gene namesi
Name:rnf-121
ORF Names:C16C10.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC16C10.5 ; CE49432 ; WBGene00007626 ; rnf-121

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563221 – 409RING finger protein 121Add BLAST409

Proteomic databases

EPDiQ09251
PaxDbiQ09251
PeptideAtlasiQ09251

Expressioni

Gene expression databases

BgeeiWBGene00007626

Interactioni

Protein-protein interaction databases

BioGridi47529, 2 interactors
STRINGi6239.C16C10.5

Structurei

3D structure databases

ProteinModelPortaliQ09251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNF121 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 358RING-typePROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1734 Eukaryota
ENOG410XP8B LUCA
HOGENOMiHOG000021822
InParanoidiQ09251
KOiK15698
OrthoDBiEOG091G09YK
PhylomeDBiQ09251

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q09251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFSYFISIF TANLSPTFPC RKVNQLNYFY QLLNLKCFFR SIFKIGHFPR
60 70 80 90 100
GSPLYLLEKS ITFSKIISIF SGHRMGQHGA IRLQNEVQEG MPPPHELTEE
110 120 130 140 150
EQWAEEHRKM HEKHKGHEAM HMEMMVIFMI SVIVGQIFLV TWKRKHFKSY
160 170 180 190 200
QMCTLIGMLT IPVYVCFNRS WYRFLATWLV FCIFSAFIWL KASAQHISGG
210 220 230 240 250
TPRFVYKWFL FLHKLSYVLG VVGYLIMMGA LLGFHVLFGV SQPTLMDAGI
260 270 280 290 300
LFMFYGVYYG VLGRDFAHIC TARMASRIGY YTPEGLPKKH LEDGVCAVCG
310 320 330 340 350
GRLDDSEHVH DADAVVTTKM VEDEDEKLYK LSCGHVFHEF CIRGWVVVGK
360 370 380 390 400
LQTCPYCKER VDLQRMFKNP WEKPHLFYGK LLDWIRYLVC WQPLIVTAVQ

GLTTWMGLE
Length:409
Mass (Da):47,627
Last modified:November 1, 1997 - v1
Checksum:i6AB33FC9D026C461
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46787 Genomic DNA Translation: CAA86743.1
PIRiT19326
RefSeqiNP_497832.2, NM_065431.5

Genome annotation databases

GeneIDi182681
KEGGicel:CELE_C16C10.5

Similar proteinsi

Entry informationi

Entry nameiRN121_CAEEL
AccessioniPrimary (citable) accession number: Q09251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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