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Entry version 159 (02 Jun 2021)
Sequence version 2 (27 May 2002)
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Protein

Egg-laying defective protein 27

Gene

egl-27

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages (PubMed:25446273).

Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.

5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri439 – 485GATA-type; atypicalPROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Egg-laying defective protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:egl-27Imported
ORF Names:C04A2.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C04A2.3a ; CE31287 ; WBGene00001194 ; egl-27
C04A2.3b ; CE47754 ; WBGene00001194 ; egl-27
C04A2.3c ; CE33268 ; WBGene00001194 ; egl-27
C04A2.3d ; CE47784 ; WBGene00001194 ; egl-27

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shortened lifespan and reduced survival in response to heat stress. Impaired differentiation of the Y rectal cell to the PDA neuron with the Y cell remaining undifferentiated in its original rectal location. Double RNAi-mediated knockdown with lin-40 results in delayed cell cycle progression in mesodermal and endodermal embryonic lineages, but accelerated cell cycle progression in a subset of embryonic lineages (PubMed:25446273).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835111 – 1129Egg-laying defective protein 27Add BLAST1129

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q09228

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09228

PeptideAtlas

More...
PeptideAtlasi
Q09228

PRoteomics IDEntifications database

More...
PRIDEi
Q09228

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q09228

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression detected in anterior intestine and head region.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression detected from the 50-cell stage of embryogenesis through to adulthood. In the adult, expression increases two-fold between day 4 and day 14.4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By starvation, heat stress, oxidative stress, and UV stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001194, Expressed in material anatomical entity and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q09228, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ceh-6, sem-4 and sox-2 (PubMed:22493276).

Interacts with wdr-5.1 (PubMed:25124442).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
39459, 20 interactors

Database of interacting proteins

More...
DIPi
DIP-61372N

Protein interaction database and analysis system

More...
IntActi
Q09228, 7 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C04A2.3a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 223BAHPROSITE-ProRule annotationAdd BLAST137
Domaini224 – 327ELM2PROSITE-ProRule annotationAdd BLAST104
Domaini332 – 384SANTPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni388 – 434DisorderedSequence analysisAdd BLAST47
Regioni487 – 636DisorderedSequence analysisAdd BLAST150
Regioni693 – 717DisorderedSequence analysisAdd BLAST25
Regioni790 – 814DisorderedSequence analysisAdd BLAST25
Regioni899 – 950DisorderedSequence analysisAdd BLAST52
Regioni982 – 1040DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi399 – 413Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi416 – 432Polar residuesSequence analysisAdd BLAST17
Compositional biasi489 – 517Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi518 – 543Polar residuesSequence analysisAdd BLAST26
Compositional biasi582 – 604Polar residuesSequence analysisAdd BLAST23
Compositional biasi614 – 628Acidic residuesSequence analysisAdd BLAST15
Compositional biasi912 – 934Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi935 – 950Polar residuesSequence analysisAdd BLAST16
Compositional biasi982 – 998Polar residuesSequence analysisAdd BLAST17
Compositional biasi999 – 1035Basic and acidic residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SANT domain and GATA-type zinc finger are required for conversion of the Y rectal cell to the PDA neuron.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri439 – 485GATA-type; atypicalPROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2133, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012470_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
DWHHANG

Database of Orthologous Groups

More...
OrthoDBi
315192at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202, ZnF_GATA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform aImported (identifier: Q09228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRFDSQCSS EDVNKEDECV PSSSEDSQDG VSSPMENDDE PEFSQKHYDI
60 70 80 90 100
EPCYYSLTGK SDRNCRGIVY RYRQDSDLKG FQSHDGTLYR LRDSVFVEVS
110 120 130 140 150
QNEPYVIAAI CGFKYTKRDH VVVKLTRYFR ADDIPEISLN LMKQERAELE
160 170 180 190 200
INPHLCPQSL NRELFNSELQ ITQPVSCLRG KCIVEYVKDV RHARTVADFS
210 220 230 240 250
LDNDTFFFCL HYNQDSTKLA STHYAIRVGT SFQATLPPMA ECSVGDDSDR
260 270 280 290 300
DELLYRPNSI ESGEEEDYIK LARCYRTYTL SGNHMLDSQK NARSLQVSDL
310 320 330 340 350
LMDEAIIQLH RSGYKIDDAL SELNANDIIL TTDVDNMTQD DAKKFAKGIK
360 370 380 390 400
QLGKNFSRIH RELLPHHSRE QLVSYYYLWK KTPEATKPKQ AARRVNPTSI
410 420 430 440 450
KRPTKEKVKA SRPTSTEYLD FDSASESDVE NNGPSGRACH HCYGAESKDW
460 470 480 490 500
HHANGLLLCT DCRLHYKKYG QLRQIANRPS QVPACLFKRS NSDEEESGVR
510 520 530 540 550
TRAGKKEQRR RTPSSMSETP DRRSPSTVSN GAPNLTAEET PTKKLNGSVK
560 570 580 590 600
RAPKRPLHNG VINNVEKSNS SEEPASPTTP PPTLTNGLTN GHGPESSTPN
610 620 630 640 650
GETISKRMKV EPSYDDDDDE EEGKMTIDEG DDDPMPVLNG FKKEESVEEI
660 670 680 690 700
KLELNGTIKK ENGVETDPTT PTCSMEAENE VCETPAVVSV EIRDETNGET
710 720 730 740 750
NSDLKDDENV EPDSPEDTFE LGSNVEFETK NAMFVRSIVR SCGPRCARTD
760 770 780 790 800
LIFKIKVGGV WEKSIKEKEE RKKVHLQNQR IQDSEKVAIQ QNQIKKEQQQ
810 820 830 840 850
SQPTPQQIHQ QQAQQNAQHL QQLQQAVMLG HLPPEVLRQM MPPQFGVDPT
860 870 880 890 900
AILMQQMMAG QQSQGVNAAF QHQMALQQQL EAHQVQFQLM MAHQHQQKMI
910 920 930 940 950
AEQQQQQRHA AAQQLREREQ REQRERERER QHQQQAQQAL HQQQQQHAAA
960 970 980 990 1000
AANQLNPAMM QMMALMANSA ASQQDIARLM EMAAQQQQQQ QQAAQAQAQR
1010 1020 1030 1040 1050
DQERERRERE AREREAARER EREQAAREAA ARDQAAREHA QAVQAAAAAA
1060 1070 1080 1090 1100
QQAQALTPDM QHMHLLQQLM LNPALMMQLQ QAQAQQQQQQ PQVTNPLQML
1110 1120
QHGMAAQSAN QAEMMRRIHP EPAMRPQHQ
Length:1,129
Mass (Da):128,359
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E0F88BBC0AF43E8
GO
Isoform bImported (identifier: Q09228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
     294-296: Missing.

Show »
Length:985
Mass (Da):111,758
Checksum:iC7079A59464B1FC2
GO
Isoform cImported (identifier: Q09228-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-515: Missing.
     886-887: Missing.

Show »
Length:612
Mass (Da):69,063
Checksum:i0E89CAA5C336D54D
GO
Isoform dImported (identifier: Q09228-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.
     294-296: Missing.

Show »
Length:888
Mass (Da):100,631
Checksum:iA03FCDFFD91C6747
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AQX3A0A0K3AQX3_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,090Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AWS8A0A0K3AWS8_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
988Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AQW8A0A0K3AQW8_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARG1A0A0K3ARG1_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,093Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ATV0A0A0K3ATV0_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ATV3A0A0K3ATV3_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,092Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ATV6A0A0K3ATV6_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
983Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AWS4A0A0K3AWS4_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,095Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARG6A0A0K3ARG6_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
986Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AUG2A0A0K3AUG2_CAEEL
Egg-laying defective protein 27
egl-27 C04A2.3, CELE_C04A2.3
1,124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti671P → L in AAD27790 (PubMed:9927605).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198641 – 515Missing in isoform c. CuratedAdd BLAST515
Alternative sequenceiVSP_0479401 – 238Missing in isoform d. CuratedAdd BLAST238
Alternative sequenceiVSP_0479391 – 141Missing in isoform b. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_001608294 – 296Missing in isoform b and isoform d. 1 Publication3
Alternative sequenceiVSP_001609886 – 887Missing in isoform c. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF096618 mRNA Translation: AAD27790.1
BX284602 Genomic DNA Translation: CCD62843.1
BX284602 Genomic DNA Translation: CCD62844.2
BX284602 Genomic DNA Translation: CCD62845.1
BX284602 Genomic DNA Translation: CCM09405.1

Protein sequence database of the Protein Information Resource

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PIRi
T43674

NCBI Reference Sequences

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RefSeqi
NP_001021911.2, NM_001026740.4
NP_001021912.1, NM_001026741.2
NP_001263660.1, NM_001276731.1 [Q09228-4]
NP_741012.1, NM_171011.3 [Q09228-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
C04A2.3a.1; C04A2.3a.1; WBGene00001194 [Q09228-1]
C04A2.3b.1; C04A2.3b.1; WBGene00001194 [Q09228-2]
C04A2.3c.1; C04A2.3c.1; WBGene00001194 [Q09228-3]
C04A2.3c.2; C04A2.3c.2; WBGene00001194 [Q09228-3]
C04A2.3d.1; C04A2.3d.1; WBGene00001194 [Q09228-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
174121

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_C04A2.3

UCSC genome browser

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UCSCi
C04A2.3a, c. elegans [Q09228-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096618 mRNA Translation: AAD27790.1
BX284602 Genomic DNA Translation: CCD62843.1
BX284602 Genomic DNA Translation: CCD62844.2
BX284602 Genomic DNA Translation: CCD62845.1
BX284602 Genomic DNA Translation: CCM09405.1
PIRiT43674
RefSeqiNP_001021911.2, NM_001026740.4
NP_001021912.1, NM_001026741.2
NP_001263660.1, NM_001276731.1 [Q09228-4]
NP_741012.1, NM_171011.3 [Q09228-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi39459, 20 interactors
DIPiDIP-61372N
IntActiQ09228, 7 interactors
STRINGi6239.C04A2.3a

PTM databases

iPTMnetiQ09228

Proteomic databases

EPDiQ09228
PaxDbiQ09228
PeptideAtlasiQ09228
PRIDEiQ09228

Genome annotation databases

EnsemblMetazoaiC04A2.3a.1; C04A2.3a.1; WBGene00001194 [Q09228-1]
C04A2.3b.1; C04A2.3b.1; WBGene00001194 [Q09228-2]
C04A2.3c.1; C04A2.3c.1; WBGene00001194 [Q09228-3]
C04A2.3c.2; C04A2.3c.2; WBGene00001194 [Q09228-3]
C04A2.3d.1; C04A2.3d.1; WBGene00001194 [Q09228-4]
GeneIDi174121
KEGGicel:CELE_C04A2.3
UCSCiC04A2.3a, c. elegans [Q09228-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
174121
WormBaseiC04A2.3a ; CE31287 ; WBGene00001194 ; egl-27
C04A2.3b ; CE47754 ; WBGene00001194 ; egl-27
C04A2.3c ; CE33268 ; WBGene00001194 ; egl-27
C04A2.3d ; CE47784 ; WBGene00001194 ; egl-27

Phylogenomic databases

eggNOGiKOG2133, Eukaryota
GeneTreeiENSGT00940000153615
HOGENOMiCLU_012470_0_0_1
InParanoidiQ09228
OMAiDWHHANG
OrthoDBi315192at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:Q09228

Gene expression databases

BgeeiWBGene00001194, Expressed in material anatomical entity and 5 other tissues
ExpressionAtlasiQ09228, baseline and differential

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
Gene3Di2.30.30.490, 1 hit
InterProiView protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA
PfamiView protein in Pfam
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit
SMARTiView protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit
PS51293, SANT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGL27_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09228
Secondary accession number(s): J7RNK9
, Q09229, Q86LT4, Q8MQF3, Q9XYD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: June 2, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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