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Protein

Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

Gene

C08B11.8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man9GlcNAc2-PP-Dol (By similarity).By similarity

Catalytic activityi

Dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-CEL-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT57 Glycosyltransferase Family 57

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC:2.4.1.267)
Alternative name(s):
Asparagine-linked glycosylation protein 6 homolog
Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
Gene namesi
ORF Names:C08B11.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC08B11.8 ; CE01478 ; WBGene00007435

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741571 – 503Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferaseAdd BLAST503

Proteomic databases

PaxDbiQ09226
PRIDEiQ09226

Expressioni

Gene expression databases

BgeeiWBGene00007435 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

Protein-protein interaction databases

STRINGi6239.C08B11.8

Structurei

3D structure databases

ProteinModelPortaliQ09226
SMRiQ09226
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2575 Eukaryota
ENOG410XQK1 LUCA
GeneTreeiENSGT00550000075073
HOGENOMiHOG000195048
InParanoidiQ09226
KOiK03848
OMAiYLPCFTF
OrthoDBiEOG091G0AVE
PhylomeDBiQ09226

Family and domain databases

InterProiView protein in InterPro
IPR039488 ALG6
IPR004856 Glyco_trans_ALG6/ALG8
PANTHERiPTHR12413 PTHR12413, 1 hit
PTHR12413:SF1 PTHR12413:SF1, 1 hit
PfamiView protein in Pfam
PF03155 Alg6_Alg8, 1 hit

Sequencei

Sequence statusi: Complete.

Q09226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKERIKDKAW RPQFIKLNNP DTSKKIVSQK SKKPEIVDLS SPGNNDLVTI
60 70 80 90 100
SILCVLLCFQ LAISLNPHSG ESQPPMYGDY EAQRHWMEIT VNLPIEQWYL
110 120 130 140 150
NGTHNDLLYW GLDYPPITAY HHYLLGVISN KINKKWVELT TSRGYESIAH
160 170 180 190 200
KLFMRLSAII PFYIFYLPPL IFYFTRSKKM SPILYALALL YPSLLVIDNG
210 220 230 240 250
HFQYNSISLG LFLATYMFLT KNFTIIGSIL FVAALNYKQM ELYHALPVFV
260 270 280 290 300
FILARSINKT QLFNSFRRIL TIGLFVVGTF LIIWLPFLLT GTAKDVIIRV
310 320 330 340 350
FPFNRGLYED KVASFWCAFS FILKRLPLQS VQIYISTALV LAGSAPSLLV
360 370 380 390 400
LFLRPTEKQF RISLTATGLS FFLFSFHVHE KTILLAAVPA LLLISEYTSL
410 420 430 440 450
VIWFLNITNI SIFSLCVKDN FALSLSFFFA YFVVSYAYTA PRKISHILTI
460 470 480 490 500
LIGFAICILE LYGPSNQRFP HIYQLANAFF SCVHFIYFLL YLSFASFEKT

KKE
Length:503
Mass (Da):57,907
Last modified:November 1, 1995 - v1
Checksum:i06A5F20DE1AEFC65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46676 Genomic DNA Translation: CAA86666.1
PIRiT19071
RefSeqiNP_495685.1, NM_063284.1
UniGeneiCel.15950

Genome annotation databases

EnsemblMetazoaiC08B11.8; C08B11.8; WBGene00007435
GeneIDi182392
KEGGicel:CELE_C08B11.8
UCSCiC08B11.8 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46676 Genomic DNA Translation: CAA86666.1
PIRiT19071
RefSeqiNP_495685.1, NM_063284.1
UniGeneiCel.15950

3D structure databases

ProteinModelPortaliQ09226
SMRiQ09226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C08B11.8

Protein family/group databases

CAZyiGT57 Glycosyltransferase Family 57

Proteomic databases

PaxDbiQ09226
PRIDEiQ09226

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC08B11.8; C08B11.8; WBGene00007435
GeneIDi182392
KEGGicel:CELE_C08B11.8
UCSCiC08B11.8 c. elegans

Organism-specific databases

CTDi182392
WormBaseiC08B11.8 ; CE01478 ; WBGene00007435

Phylogenomic databases

eggNOGiKOG2575 Eukaryota
ENOG410XQK1 LUCA
GeneTreeiENSGT00550000075073
HOGENOMiHOG000195048
InParanoidiQ09226
KOiK03848
OMAiYLPCFTF
OrthoDBiEOG091G0AVE
PhylomeDBiQ09226

Enzyme and pathway databases

UniPathwayi
UPA00378

ReactomeiR-CEL-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Miscellaneous databases

PROiPR:Q09226

Gene expression databases

BgeeiWBGene00007435 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR039488 ALG6
IPR004856 Glyco_trans_ALG6/ALG8
PANTHERiPTHR12413 PTHR12413, 1 hit
PTHR12413:SF1 PTHR12413:SF1, 1 hit
PfamiView protein in Pfam
PF03155 Alg6_Alg8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALG6_CAEEL
AccessioniPrimary (citable) accession number: Q09226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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