UniProtKB - Q09199 (B4GN2_MOUSE)
Protein
Beta-1,4 N-acetylgalactosaminyltransferase 2
Gene
B4galnt2
Organism
Mus musculus (Mouse)
Status
Functioni
Responsible for synthesis of murine T-lymphocyte CT antigen. Can transfer N-acetylgalactosamine moiety from UDP-GalNAc to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non-reducing terminal tetrasaccharide Sda blood group structure.
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- acetylgalactosaminyltransferase activity Source: UniProtKB
GO - Biological processi
- lipid glycosylation Source: InterPro
- negative regulation of cell-cell adhesion Source: UniProtKB
- protein glycosylation Source: MGI
- UDP-N-acetylgalactosamine metabolic process Source: UniProtKB
- UDP-N-acetylglucosamine metabolic process Source: MGI
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-446203, Asparagine N-linked glycosylation R-MMU-9037629, Lewis blood group biosynthesis |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT12, Glycosyltransferase Family 12 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:B4galnt2 Synonyms:Galgt2, Ggm3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1342058, B4galnt2 |
Subcellular locationi
Golgi apparatus
Golgi apparatus
- integral component of Golgi membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 32 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 17 | |
Topological domaini | 33 – 510 | LumenalSequence analysisAdd BLAST | 478 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059104 | 1 – 510 | Beta-1,4 N-acetylgalactosaminyltransferase 2Add BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 390 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q09199 |
PaxDbi | Q09199 |
PRIDEi | Q09199 |
PTM databases
GlyGeni | Q09199, 1 site |
iPTMneti | Q09199 |
PhosphoSitePlusi | Q09199 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000013418, Expressed in duodenum and 85 other tissues |
ExpressionAtlasi | Q09199, baseline and differential |
Genevisiblei | Q09199, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037239 |
Miscellaneous databases
RNActi | Q09199, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 2 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTK7, Eukaryota |
GeneTreei | ENSGT00390000006679 |
HOGENOMi | CLU_036051_1_0_1 |
InParanoidi | Q09199 |
OMAi | NHLQCST |
OrthoDBi | 363090at2759 |
PhylomeDBi | Q09199 |
TreeFami | TF332297 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR001173, Glyco_trans_2-like IPR011143, GM2_synthase IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit |
PIRSFi | PIRSF000474, GM2_GD2_synthase, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
Q09199-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSSVSFASF RFPWLLKTFV LMVGLATVAF MVRKVSLTTD FSTFKPKFPE
60 70 80 90 100
PARVDPVLKL LPEEHLRKLF TYSDIWLFPK NQCDCNSGKL RMKYKFQDAY
110 120 130 140 150
NQKDLPAVNA RRQAEFEHFQ RREGLPRPPP LLAPPNLPFG YPVHGVEVMP
160 170 180 190 200
LHTILIPGLQ YEGPDAPVYE VILKASLGTL NTLADVPDDE VQGRGQRQLT
210 220 230 240 250
ISTRHRKVLN FILQHVTYTS TEYYLHKVDT VSMEYESSVA KFPVTIKQQT
260 270 280 290 300
VPKLYDPGPE RKIRNLVTIA TKTFLRPHKL KILLQSIRKY YPDITVIVAD
310 320 330 340 350
DSKEPLEIND DYVEYYTMPF GKGWFAGRNL AISQVTTKYV LWVDDDFLFS
360 370 380 390 400
DKTKIEVLVD VLEKTELDVV GGSVQGNTYQ FRLLYEQTKN GSCLHQRWGS
410 420 430 440 450
FQALDGFPGC TLTSGVVNFF LAHTEQLRRV GFDPILQRVA HGEFFIDGLG
460 470 480 490 500
RLLVGSCPGV IINHQVRTPP KDPKLAALEK TYDKYRANTN SVIQFKVALQ
510
YFKNHLYCST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L30104 mRNA Translation: AAA39802.1 |
CCDSi | CCDS25285.1 |
PIRi | A53802 |
RefSeqi | NP_032107.1, NM_008081.3 |
Genome annotation databases
Ensembli | ENSMUST00000038343; ENSMUSP00000037239; ENSMUSG00000013418 |
GeneIDi | 14422 |
KEGGi | mmu:14422 |
UCSCi | uc007lax.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L30104 mRNA Translation: AAA39802.1 |
CCDSi | CCDS25285.1 |
PIRi | A53802 |
RefSeqi | NP_032107.1, NM_008081.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037239 |
Protein family/group databases
CAZyi | GT12, Glycosyltransferase Family 12 |
PTM databases
GlyGeni | Q09199, 1 site |
iPTMneti | Q09199 |
PhosphoSitePlusi | Q09199 |
Proteomic databases
MaxQBi | Q09199 |
PaxDbi | Q09199 |
PRIDEi | Q09199 |
Protocols and materials databases
Antibodypediai | 2589, 70 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000038343; ENSMUSP00000037239; ENSMUSG00000013418 |
GeneIDi | 14422 |
KEGGi | mmu:14422 |
UCSCi | uc007lax.1, mouse |
Organism-specific databases
CTDi | 124872 |
MGIi | MGI:1342058, B4galnt2 |
Phylogenomic databases
eggNOGi | ENOG502QTK7, Eukaryota |
GeneTreei | ENSGT00390000006679 |
HOGENOMi | CLU_036051_1_0_1 |
InParanoidi | Q09199 |
OMAi | NHLQCST |
OrthoDBi | 363090at2759 |
PhylomeDBi | Q09199 |
TreeFami | TF332297 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Reactomei | R-MMU-446203, Asparagine N-linked glycosylation R-MMU-9037629, Lewis blood group biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 14422, 2 hits in 17 CRISPR screens |
PROi | PR:Q09199 |
RNActi | Q09199, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000013418, Expressed in duodenum and 85 other tissues |
ExpressionAtlasi | Q09199, baseline and differential |
Genevisiblei | Q09199, MM |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR001173, Glyco_trans_2-like IPR011143, GM2_synthase IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit |
PIRSFi | PIRSF000474, GM2_GD2_synthase, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4GN2_MOUSE | |
Accessioni | Q09199Primary (citable) accession number: Q09199 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families