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Protein

Beta-1,4 N-acetylgalactosaminyltransferase 2

Gene

B4galnt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for synthesis of murine T-lymphocyte CT antigen. Can transfer N-acetylgalactosamine moiety from UDP-GalNAc to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non-reducing terminal tetrasaccharide Sda blood group structure.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • acetylgalactosaminyltransferase activity Source: UniProtKB

GO - Biological processi

  • lipid glycosylation Source: InterPro
  • negative regulation of cell-cell adhesion Source: UniProtKB
  • protein glycosylation Source: MGI
  • UDP-N-acetylgalactosamine metabolic process Source: UniProtKB
  • UDP-N-acetylglucosamine metabolic process Source: MGI

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-446203 Asparagine N-linked glycosylation
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT12 Glycosyltransferase Family 12

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC:2.4.1.-)
Gene namesi
Name:B4galnt2
Synonyms:Galgt2, Ggm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1342058 B4galnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini33 – 510LumenalSequence analysisAdd BLAST478

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000591041 – 510Beta-1,4 N-acetylgalactosaminyltransferase 2Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ09199
PaxDbiQ09199
PRIDEiQ09199

PTM databases

iPTMnetiQ09199
PhosphoSitePlusiQ09199

Expressioni

Gene expression databases

BgeeiENSMUSG00000013418
CleanExiMM_B4GALNT2
ExpressionAtlasiQ09199 baseline and differential
GenevisibleiQ09199 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037239

Structurei

3D structure databases

ProteinModelPortaliQ09199
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF61 Eukaryota
ENOG4111N56 LUCA
GeneTreeiENSGT00390000006679
HOGENOMiHOG000220853
HOVERGENiHBG004812
InParanoidiQ09199
KOiK09655
OMAiYYTMPFG
OrthoDBiEOG091G04CW
PhylomeDBiQ09199
TreeFamiTF332297

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR001173 Glyco_trans_2-like
IPR011143 GM2_synthase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
PIRSFiPIRSF000474 GM2_GD2_synthase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q09199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSVSFASF RFPWLLKTFV LMVGLATVAF MVRKVSLTTD FSTFKPKFPE
60 70 80 90 100
PARVDPVLKL LPEEHLRKLF TYSDIWLFPK NQCDCNSGKL RMKYKFQDAY
110 120 130 140 150
NQKDLPAVNA RRQAEFEHFQ RREGLPRPPP LLAPPNLPFG YPVHGVEVMP
160 170 180 190 200
LHTILIPGLQ YEGPDAPVYE VILKASLGTL NTLADVPDDE VQGRGQRQLT
210 220 230 240 250
ISTRHRKVLN FILQHVTYTS TEYYLHKVDT VSMEYESSVA KFPVTIKQQT
260 270 280 290 300
VPKLYDPGPE RKIRNLVTIA TKTFLRPHKL KILLQSIRKY YPDITVIVAD
310 320 330 340 350
DSKEPLEIND DYVEYYTMPF GKGWFAGRNL AISQVTTKYV LWVDDDFLFS
360 370 380 390 400
DKTKIEVLVD VLEKTELDVV GGSVQGNTYQ FRLLYEQTKN GSCLHQRWGS
410 420 430 440 450
FQALDGFPGC TLTSGVVNFF LAHTEQLRRV GFDPILQRVA HGEFFIDGLG
460 470 480 490 500
RLLVGSCPGV IINHQVRTPP KDPKLAALEK TYDKYRANTN SVIQFKVALQ
510
YFKNHLYCST
Length:510
Mass (Da):58,317
Last modified:November 1, 1995 - v1
Checksum:i013783C80ADEC3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L30104 mRNA Translation: AAA39802.1
CCDSiCCDS25285.1
PIRiA53802
RefSeqiNP_032107.1, NM_008081.3
UniGeneiMm.340702

Genome annotation databases

EnsembliENSMUST00000038343; ENSMUSP00000037239; ENSMUSG00000013418
GeneIDi14422
KEGGimmu:14422
UCSCiuc007lax.1 mouse

Similar proteinsi

Entry informationi

Entry nameiB4GN2_MOUSE
AccessioniPrimary (citable) accession number: Q09199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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