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Protein

ADP,ATP carrier protein

Gene

anc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100ADPBy similarity1
Binding sitei112ADPBy similarity1
Binding sitei257ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: PomBase

GO - Biological processi

  • mitochondrial ADP transmembrane transport Source: PomBase
  • mitochondrial ATP transmembrane transport Source: PomBase
  • regulation of mitochondrial membrane permeability Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-SPO-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein
Alternative name(s):
ADP/ATP translocase
Adenine nucleotide translocator
Short name:
ANT
Gene namesi
Name:anc1
ORF Names:SPBC530.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC530.10c
PomBaseiSPBC530.10c anc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 54Helical; Name=1By similarityAdd BLAST28
Transmembranei95 – 119Helical; Name=2By similarityAdd BLAST25
Transmembranei128 – 148Helical; Name=3By similarityAdd BLAST21
Transmembranei198 – 219Helical; Name=4By similarityAdd BLAST22
Transmembranei233 – 253Helical; Name=5By similarityAdd BLAST21
Transmembranei293 – 313Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905921 – 322ADP,ATP carrier proteinAdd BLAST322

Proteomic databases

MaxQBiQ09188
PaxDbiQ09188
PRIDEiQ09188

PTM databases

iPTMnetiQ09188

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277416, 3 interactors
IntActiQ09188, 1 interactor
STRINGi4896.SPBC530.10c.1

Structurei

3D structure databases

ProteinModelPortaliQ09188
SMRiQ09188
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 118Solcar 1Add BLAST94
Repeati130 – 222Solcar 2Add BLAST93
Repeati230 – 316Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 262Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi257 – 262Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165727
InParanoidiQ09188
KOiK05863
OMAiECFKRTA
OrthoDBiEOG092C3PSA
PhylomeDBiQ09188

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q09188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSAAAAA STPVNANTIT ETKNSTFFFD FMMGGVSAAV SKTAAAPIER
60 70 80 90 100
VKLLIQNQDE MIRAGRLSHR YKGIGECFKR TAAEEGVISL WRGNTANVLR
110 120 130 140 150
YFPTQALNFA FKDKFKKMFG YKKERDGYAK WFAGNLASGG AAGAASLLFV
160 170 180 190 200
YSLDYARTRL ANDAKSAKKG GERQFNGLVD VYRKTYRSDG LRGLYRGFGP
210 220 230 240 250
SVVGIVVYRG LYFGMYDTLK PVVLVGPLEG NFLASFLLGW AVTTGSGVAS
260 270 280 290 300
YPLDTIRRRM MMTSGEAVKY SSSFECGRQI LAKEGARSFF KGAGANILRG
310 320
VAGAGVLSIY DQVQLLMFGK KF
Length:322
Mass (Da):35,020
Last modified:November 1, 1996 - v1
Checksum:i8AC3D16A40F41AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49974 Genomic DNA Translation: CAA90275.1
CU329671 Genomic DNA Translation: CAA19176.1
D89102 mRNA Translation: BAA13765.1
PIRiT40526
T42011
RefSeqiNP_595323.1, NM_001021230.2

Genome annotation databases

EnsemblFungiiSPBC530.10c.1; SPBC530.10c.1:pep; SPBC530.10c
GeneIDi2540900
KEGGispo:SPBC530.10c

Similar proteinsi

Entry informationi

Entry nameiADT_SCHPO
AccessioniPrimary (citable) accession number: Q09188
Secondary accession number(s): P78754
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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