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Protein

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Gene

pdb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

  • pyruvate dehydrogenase (acetyl-transferring) activity Source: PomBase

GO - Biological processi

  • acetyl-CoA biosynthetic process from pyruvate Source: PomBase
  • glycolytic process Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-SPO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-SPO-389661 Glyoxylate metabolism and glycine degradation
R-SPO-5362517 Signaling by Retinoic Acid
R-SPO-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Name:pdb1
ORF Names:SPBC30D10.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC30D10.13c
PomBaseiSPBC30D10.13c pdb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020460? – 366Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ09171
PaxDbiQ09171
PRIDEiQ09171

PTM databases

iPTMnetiQ09171

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.

Protein-protein interaction databases

BioGridi276804, 4 interactors
STRINGi4896.SPBC30D10.13c.1

Structurei

3D structure databases

ProteinModelPortaliQ09171
SMRiQ09171
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000281450
InParanoidiQ09171
KOiK00162
OMAiSRMRHHC
OrthoDBiEOG092C45LK
PhylomeDBiQ09171

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR027110 PDHB
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PANTHERiPTHR11624:SF94 PTHR11624:SF94, 1 hit
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLQKFGEI VGTSRSWKLL SSTIAKRYSS SSNGVKEMTV RDALNSAMEE
60 70 80 90 100
EMKRDDRVFL IGEEVAQYNG AYKISRGLLD KFGPKRVIDT PITEMGFTGL
110 120 130 140 150
ATGAAFAGLR PICEFMTFNF SMQAIDHIVN SAARTLYMSG GIQACPIVFR
160 170 180 190 200
GPNGPAAAVA AQHSQHFAPW YGSIPGLKVV SPYSAEDARG LLKAAIRDPN
210 220 230 240 250
PVVVLENEIL YGKTFPISKE ALSEDFVLPF GLAKVERPGK DITIVGESIS
260 270 280 290 300
VVTALEAADK LKADYGVEAE VINLRSIRPL DINTIAASVK KTNRIVTVDQ
310 320 330 340 350
AYSQHGIGSE IAAQIMESDA FDYLDAPVER VSMADVPMPY SHPVEAASVP
360
NADVVVAAAK KCLYIK
Length:366
Mass (Da):39,624
Last modified:November 1, 1995 - v1
Checksum:i5835A6872F6EDC0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75648 Genomic DNA Translation: CAA53303.1
CU329671 Genomic DNA Translation: CAB10808.1
PIRiJC4080
RefSeqiNP_596272.1, NM_001022193.2

Genome annotation databases

EnsemblFungiiSPBC30D10.13c.1; SPBC30D10.13c.1:pep; SPBC30D10.13c
GeneIDi2540273
KEGGispo:SPBC30D10.13c

Similar proteinsi

Entry informationi

Entry nameiODPB_SCHPO
AccessioniPrimary (citable) accession number: Q09171
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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