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Protein

Fibroblast growth factor receptor homolog 2

Gene

btl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei748ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei864Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi718 – 726ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fibroblast growth factor-activated receptor activity Source: FlyBase
  • protein tyrosine kinase activity Source: FlyBase
  • transmembrane receptor protein tyrosine kinase activity Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704 PI3K Cascade
R-DME-1257604 PIP3 activates AKT signaling
R-DME-190322 FGFR4 ligand binding and activation
R-DME-190370 FGFR1b ligand binding and activation
R-DME-190371 FGFR3b ligand binding and activation
R-DME-190372 FGFR3c ligand binding and activation
R-DME-190373 FGFR1c ligand binding and activation
R-DME-190375 FGFR2c ligand binding and activation
R-DME-190377 FGFR2b ligand binding and activation
R-DME-445144 Signal transduction by L1
R-DME-5654219 Phospholipase C-mediated cascade: FGFR1
R-DME-5654221 Phospholipase C-mediated cascade, FGFR2
R-DME-5654227 Phospholipase C-mediated cascade, FGFR3
R-DME-5654228 Phospholipase C-mediated cascade, FGFR4
R-DME-5654688 SHC-mediated cascade:FGFR1
R-DME-5654689 PI-3K cascade:FGFR1
R-DME-5654693 FRS-mediated FGFR1 signaling
R-DME-5654695 PI-3K cascade:FGFR2
R-DME-5654699 SHC-mediated cascade:FGFR2
R-DME-5654700 FRS-mediated FGFR2 signaling
R-DME-5654704 SHC-mediated cascade:FGFR3
R-DME-5654706 FRS-mediated FGFR3 signaling
R-DME-5654710 PI-3K cascade:FGFR3
R-DME-5654712 FRS-mediated FGFR4 signaling
R-DME-5654719 SHC-mediated cascade:FGFR4
R-DME-5654720 PI-3K cascade:FGFR4
R-DME-5654726 Negative regulation of FGFR1 signaling
R-DME-5654727 Negative regulation of FGFR2 signaling
R-DME-5654732 Negative regulation of FGFR3 signaling
R-DME-5654733 Negative regulation of FGFR4 signaling
R-DME-5673001 RAF/MAP kinase cascade
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q09147

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor receptor homolog 2 (EC:2.7.10.1)
Alternative name(s):
Protein breathless
Tyrosine kinase 2
Short name:
dTk2
Tyrosine kinase receptor HD-311
dFGF-R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:btl
Synonyms:FR2, HD-311, Tk2
ORF Names:CG32134
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0285896 btl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 600ExtracellularSequence analysisAdd BLAST581
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei601 – 626HelicalSequence analysisAdd BLAST26
Topological domaini627 – 1052CytoplasmicSequence analysisAdd BLAST426

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001679520 – 1052Fibroblast growth factor receptor homolog 2Add BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 90PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 217PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 329PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi507 ↔ 566PROSITE-ProRule annotation
Glycosylationi526N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi541N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi576N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei895Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q09147

PRoteomics IDEntifications database

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PRIDEi
Q09147

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis, expression is seen in mesoderm, endodermal precursor cells, CNS midline cells and trachea and salivary duct ectodermal cells.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

All stages of development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0005592 Expressed in 29 organ(s), highest expression level in tracheal primordium (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q09147 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q09147 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
64900, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q09147, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0075520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q09147

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q09147

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 117Ig-like C2-type 1Add BLAST95
Domaini124 – 230Ig-like C2-type 2Add BLAST107
Domaini240 – 340Ig-like C2-type 3Add BLAST101
Domaini393 – 478Ig-like C2-type 4Add BLAST86
Domaini487 – 585Ig-like C2-type 5Add BLAST99
Domaini712 – 1000Protein kinasePROSITE-ProRule annotationAdd BLAST289

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0200 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000167157

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q09147

KEGG Orthology (KO)

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KOi
K05093

Identification of Orthologs from Complete Genome Data

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OMAi
YPEKMEK

Database of Orthologous Groups

More...
OrthoDBi
220433at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q09147

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q09147-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVPITLVM IIAIVSAAAD LGCDYGHHRC YIDVTVENSP RQRHLLSDMD
60 70 80 90 100
ITLQCVRPMA KWFYEDKFQL RATLLRLERA QSGNSGNYGC LDSQNRWYNI
110 120 130 140 150
SLVVGHKEPV GNDIASFVKL EDAPALPESD LFFQPLNESR SLKLLQPLPK
160 170 180 190 200
TVQRTAGGLF QLNCSPMDPD AKGVNISWLH NDTQILGGRG RIKLKRWSLT
210 220 230 240 250
VGQLQPEDAG SYHCELCVEQ DCQRSNPTQL EVISRKHTVP MLKPGYPRNT
260 270 280 290 300
SIALGDNVSI ECLLEDSALE PKITWLHKGN ADNIDDLLQR LREQSQLPVD
310 320 330 340 350
VTRLITRMDE PQVLRLGNVL MEDGGWYICI AENQVGRTVA ASYVDLYSPS
360 370 380 390 400
DTTTVRTTTT TTVASPIPTA STGEDNDDDV ENPAAEASGG VGPPVFRKEL
410 420 430 440 450
KRLQHSLSGN TVNLACPVYG KANITWTKDK KPLNRELGVY VQKNWTLRFV
460 470 480 490 500
EATSEDSGLY NCKVCNAWGC IQFDFSVQIN DRTRSAPIIV VPQNQTVKVN
510 520 530 540 550
GSLVMKCTVY SDLHPTVSWK RVVLKNASLD GLKSVEIQNL NFTVTNDSVV
560 570 580 590 600
LTLRNVTFDQ EGWYTCLASS GLGRSNSSVY LRVVSPLPPL EIYALLHAHP
610 620 630 640 650
LGFTLAAITI VALFLLGSAF ITFMLRRLRR EKLLKLRIET VHQWTKKVII
660 670 680 690 700
YRPGGEEGSG CSSGDLQMPV IRIEKQRTTV STTGTGGTDP AQGFNEYEFP
710 720 730 740 750
LDSNWEIPRQ QLSLGSILGE GAFGRVVMAE AEGLPRSPQL AETIVAVKMV
760 770 780 790 800
KEEHTDTDMA SLVREMEVMK MIGKHINIIN LLGCCSQGGP LWVIVEYAPH
810 820 830 840 850
GNLKDFLKQN RPGAPQRRSD SDGYLDDKPL ISTQHLGEKE LTKFAFQIAR
860 870 880 890 900
GMEYLASRRC IHRDLAARNV LVSDGYVMKI ADFGLARDIQ DTEYYRKNTN
910 920 930 940 950
GRLPIKWMAP ESLQEKKYDS QSDVWSYGVL LWEIMTYGDQ PYPHILSAEE
960 970 980 990 1000
LYSYLITGQR MEKPAKCSLN IYVVMRQCWH FESCARPTFA ELVESFDGIL
1010 1020 1030 1040 1050
QQASSNPNDA YLDLSMPMLE TPPSSGDEDD GSDTETFRET SPLRYQYTYK

FN
Length:1,052
Mass (Da):117,813
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74FBB9A5A2154D55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104V → I in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti104V → I in CAA51340 (PubMed:1325393).Curated1
Sequence conflicti126L → I in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti126L → I in CAA51340 (PubMed:1325393).Curated1
Sequence conflicti181N → I in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti287L → F in CAA40912 (PubMed:1849109).Curated1
Sequence conflicti293E → D in CAA40912 (PubMed:1849109).Curated1
Sequence conflicti386E → D in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti386E → D in CAA40912 (PubMed:1849109).Curated1
Sequence conflicti480 – 481ND → KH in CAA40912 (PubMed:1849109).Curated2
Sequence conflicti533K → Q in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti533K → Q in CAA40912 (PubMed:1849109).Curated1
Sequence conflicti565T → S in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti845A → P in CAA52190 (PubMed:8330538).Curated1
Sequence conflicti911 – 921ESLQEKKYDSQ → SRCRRRSTTH in CAA40912 (PubMed:1849109).CuratedAdd BLAST11
Sequence conflicti982E → Q in CAA40912 (PubMed:1849109).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X74031 mRNA Translation: CAA52190.1
AE014296 Genomic DNA Translation: AAF49759.1
AE014296 Genomic DNA Translation: AAX52746.1
X72830 Genomic DNA Translation: CAA51340.1
X57746 mRNA Translation: CAA40912.1
S55971 Genomic DNA Translation: AAB19904.1
AJ002918 Genomic DNA Translation: CAA05753.1

Protein sequence database of the Protein Information Resource

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PIRi
A39627
A44065
B49120

NCBI Reference Sequences

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RefSeqi
NP_001014583.1, NM_001014583.2
NP_729956.1, NM_168577.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.10724

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0075778; FBpp0075520; FBgn0285896
FBtr0100676; FBpp0100143; FBgn0285896

Database of genes from NCBI RefSeq genomes

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GeneIDi
39564

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG32134

UCSC genome browser

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UCSCi
CG32134-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74031 mRNA Translation: CAA52190.1
AE014296 Genomic DNA Translation: AAF49759.1
AE014296 Genomic DNA Translation: AAX52746.1
X72830 Genomic DNA Translation: CAA51340.1
X57746 mRNA Translation: CAA40912.1
S55971 Genomic DNA Translation: AAB19904.1
AJ002918 Genomic DNA Translation: CAA05753.1
PIRiA39627
A44065
B49120
RefSeqiNP_001014583.1, NM_001014583.2
NP_729956.1, NM_168577.3
UniGeneiDm.10724

3D structure databases

ProteinModelPortaliQ09147
SMRiQ09147
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64900, 26 interactors
IntActiQ09147, 6 interactors
STRINGi7227.FBpp0075520

Proteomic databases

PaxDbiQ09147
PRIDEiQ09147

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075778; FBpp0075520; FBgn0285896
FBtr0100676; FBpp0100143; FBgn0285896
GeneIDi39564
KEGGidme:Dmel_CG32134
UCSCiCG32134-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
39564
FlyBaseiFBgn0285896 btl

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000167157
InParanoidiQ09147
KOiK05093
OMAiYPEKMEK
OrthoDBi220433at2759
PhylomeDBiQ09147

Enzyme and pathway databases

BRENDAi2.7.10.1 1994
ReactomeiR-DME-109704 PI3K Cascade
R-DME-1257604 PIP3 activates AKT signaling
R-DME-190322 FGFR4 ligand binding and activation
R-DME-190370 FGFR1b ligand binding and activation
R-DME-190371 FGFR3b ligand binding and activation
R-DME-190372 FGFR3c ligand binding and activation
R-DME-190373 FGFR1c ligand binding and activation
R-DME-190375 FGFR2c ligand binding and activation
R-DME-190377 FGFR2b ligand binding and activation
R-DME-445144 Signal transduction by L1
R-DME-5654219 Phospholipase C-mediated cascade: FGFR1
R-DME-5654221 Phospholipase C-mediated cascade, FGFR2
R-DME-5654227 Phospholipase C-mediated cascade, FGFR3
R-DME-5654228 Phospholipase C-mediated cascade, FGFR4
R-DME-5654688 SHC-mediated cascade:FGFR1
R-DME-5654689 PI-3K cascade:FGFR1
R-DME-5654693 FRS-mediated FGFR1 signaling
R-DME-5654695 PI-3K cascade:FGFR2
R-DME-5654699 SHC-mediated cascade:FGFR2
R-DME-5654700 FRS-mediated FGFR2 signaling
R-DME-5654704 SHC-mediated cascade:FGFR3
R-DME-5654706 FRS-mediated FGFR3 signaling
R-DME-5654710 PI-3K cascade:FGFR3
R-DME-5654712 FRS-mediated FGFR4 signaling
R-DME-5654719 SHC-mediated cascade:FGFR4
R-DME-5654720 PI-3K cascade:FGFR4
R-DME-5654726 Negative regulation of FGFR1 signaling
R-DME-5654727 Negative regulation of FGFR2 signaling
R-DME-5654732 Negative regulation of FGFR3 signaling
R-DME-5654733 Negative regulation of FGFR4 signaling
R-DME-5673001 RAF/MAP kinase cascade
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiQ09147

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
39564

Protein Ontology

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PROi
PR:Q09147

Gene expression databases

BgeeiFBgn0005592 Expressed in 29 organ(s), highest expression level in tracheal primordium (Drosophila)
ExpressionAtlasiQ09147 differential
GenevisibleiQ09147 DM

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGFR2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09147
Secondary accession number(s): A4V1Y3, Q712V2, Q9VUC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 2, 2008
Last modified: January 16, 2019
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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