UniProtKB - Q09143 (SL7A1_MOUSE)
Protein
High affinity cationic amino acid transporter 1
Gene
Slc7a1
Organism
Mus musculus (Mouse)
Status
Functioni
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.1 Publication
(Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: MGI
- arginine transmembrane transporter activity Source: MGI
- basic amino acid transmembrane transporter activity Source: MGI
- L-arginine transmembrane transporter activity Source: MGI
- L-histidine transmembrane transporter activity Source: MGI
- L-lysine transmembrane transporter activity Source: GO_Central
- L-ornithine transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amino acid import across plasma membrane Source: MGI
- amino acid transport Source: GO_Central
- arginine transmembrane transport Source: MGI
- arginine transport Source: MGI
- basic amino acid transmembrane transport Source: MGI
- L-amino acid transport Source: MGI
- L-arginine import across plasma membrane Source: MGI
- L-histidine import across plasma membrane Source: MGI
- L-ornithine transmembrane transport Source: GO_Central
- lysine transport Source: MGI
- ornithine transport Source: MGI
- positive regulation of T cell proliferation Source: MGI
- regulation of TOR signaling Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-352230, Amino acid transport across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.3.3.1, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: High affinity cationic amino acid transporter 1Short name: CAT-1By similarity Short name: CAT1 Alternative name(s): Ecotropic retroviral leukemia receptor Ecotropic retrovirus receptor1 Publication Short name: ERR Solute carrier family 7 member 1Imported System Y+ basic amino acid transporter |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88117, Slc7a1 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Note: In the absence of SCO1 in cardiomyocytes a mislocalization to the cytoplasm is seen.1 Publication
Plasma Membrane
- apical plasma membrane Source: MGI
- basal plasma membrane Source: MGI
- basolateral plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: MGI
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 57 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 58 – 61 | ExtracellularSequence analysis | 4 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 83 – 102 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 162 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 191 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 239 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 280 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 281 – 300 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 301 – 330 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 352 – 377 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 378 – 398 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 399 – 401 | ExtracellularSequence analysis | 3 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 485 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 486 – 506 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 507 – 519 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 520 – 544 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 545 – 552 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 553 – 573 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 574 – 577 | ExtracellularSequence analysis | 4 | |
Transmembranei | 578 – 598 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 599 – 622 | CytoplasmicSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054262 | 1 – 622 | High affinity cationic amino acid transporter 1Add BLAST | 622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 223 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 616 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q09143 |
PaxDbi | Q09143 |
PeptideAtlasi | Q09143 |
PRIDEi | Q09143 |
PTM databases
GlyGeni | Q09143, 2 sites |
iPTMneti | Q09143 |
PhosphoSitePlusi | Q09143 |
SwissPalmi | Q09143 |
Expressioni
Tissue specificityi
Highest levels found in the testis and bone marrow. Not found in the liver.
Gene expression databases
Bgeei | ENSMUSG00000041313, Expressed in brain blood vessel and 269 other tissues |
Genevisiblei | Q09143, MM |
Interactioni
Subunit structurei
Interacts with TM4SF5; the interaction is negatively regulated by arginine.
By similarityProtein-protein interaction databases
IntActi | Q09143, 1 interactor |
STRINGi | 10090.ENSMUSP00000046714 |
Miscellaneous databases
RNActi | Q09143, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000155349 |
InParanoidi | Q09143 |
OrthoDBi | 439017at2759 |
PhylomeDBi | Q09143 |
TreeFami | TF315212 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q09143-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ
160 170 180 190 200
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF MPFGFSGVLS
260 270 280 290 300
GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA
310 320 330 340 350
LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP
360 370 380 390 400
MPRVIYAMAE DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD
410 420 430 440 450
LVDLMSIGTL LAYSLVAACV LVLRYQPEQP NLVYQMARTT EELDRVDQNE
460 470 480 490 500
LVSASESQTG FLPVAEKFSL KSILSPKNVE PSKFSGLIVN ISAGLLAALI
510 520 530 540 550
ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW RQPESKTKLS
560 570 580 590 600
FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH
610 620
SEEASLAAGQ AKTPDSNLDQ CK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q3N1 | E9Q3N1_MOUSE | High affinity cationic amino acid t... | Slc7a1 | 542 | Annotation score: | ||
A0A0J9YU45 | A0A0J9YU45_MOUSE | High affinity cationic amino acid t... | Slc7a1 | 142 | Annotation score: | ||
D3Z161 | D3Z161_MOUSE | High affinity cationic amino acid t... | Slc7a1 | 94 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26687 mRNA Translation: AAA37574.1 |
CCDSi | CCDS19882.1 |
PIRi | A32742 |
RefSeqi | NP_001288353.1, NM_001301424.1 NP_031539.3, NM_007513.4 XP_006504859.1, XM_006504796.1 |
Genome annotation databases
Ensembli | ENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313 |
GeneIDi | 11987 |
KEGGi | mmu:11987 |
UCSCi | uc009aos.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26687 mRNA Translation: AAA37574.1 |
CCDSi | CCDS19882.1 |
PIRi | A32742 |
RefSeqi | NP_001288353.1, NM_001301424.1 NP_031539.3, NM_007513.4 XP_006504859.1, XM_006504796.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q09143, 1 interactor |
STRINGi | 10090.ENSMUSP00000046714 |
Protein family/group databases
TCDBi | 2.A.3.3.1, the amino acid-polyamine-organocation (apc) family |
PTM databases
GlyGeni | Q09143, 2 sites |
iPTMneti | Q09143 |
PhosphoSitePlusi | Q09143 |
SwissPalmi | Q09143 |
Proteomic databases
EPDi | Q09143 |
PaxDbi | Q09143 |
PeptideAtlasi | Q09143 |
PRIDEi | Q09143 |
Protocols and materials databases
Antibodypediai | 22734, 195 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313 |
GeneIDi | 11987 |
KEGGi | mmu:11987 |
UCSCi | uc009aos.2, mouse |
Organism-specific databases
CTDi | 6541 |
MGIi | MGI:88117, Slc7a1 |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000155349 |
InParanoidi | Q09143 |
OrthoDBi | 439017at2759 |
PhylomeDBi | Q09143 |
TreeFami | TF315212 |
Enzyme and pathway databases
Reactomei | R-MMU-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 11987, 1 hit in 18 CRISPR screens |
ChiTaRSi | Slc7a1, mouse |
PROi | PR:Q09143 |
RNActi | Q09143, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041313, Expressed in brain blood vessel and 269 other tissues |
Genevisiblei | Q09143, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SL7A1_MOUSE | |
Accessioni | Q09143Primary (citable) accession number: Q09143 Secondary accession number(s): P30824 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families