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UniProtKB - Q09050 (Q09050_ECOLX)

Entry version 93 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Site-specific DNA-methyltransferase (adenine-specific)

Gene

hsdM

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, MethyltransferaseImportedARBA annotation, Transferase
Biological processRestriction systemARBA annotation
LigandS-adenosyl-L-methionineARBA annotation

Protein family/group databases

Restriction enzymes and methylases database

More...REBASEi		101720, M.Eco789ORF48080P
228511, M.Eco029ORF21875P
308147, M.Eco9285ORF21860P
3381, M.EcoBI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Site-specific DNA-methyltransferase (adenine-specific)ARBA annotation (EC:2.1.1.72ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hsdMImported
ORF Names:AC789_1c48080Imported, BMA87_20365Imported, BON76_09875Imported, CR538_21875Imported, D9H10_01350Imported, DJ503_21070Imported, DU309_07335Imported, GKF89_12715Imported, GQE93_11055Imported, NCTC9045_04999Imported, PGD_03579Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000434851 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000431028 Componenti: Unassembled WGS sequence
  • UP000272416 Componenti: Unassembled WGS sequence
  • UP000373733 Componenti: Unassembled WGS sequence
  • UP000298067 Componenti: Unassembled WGS sequence
  • UP000346445 Componenti: Unassembled WGS sequence
  • UP000254503 Componenti: Unassembled WGS sequence
  • UP000324175 Componenti: Unassembled WGS sequence
  • UP000234238 Componenti: Chromosome
  • UP000031522 Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.

ARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 108HsdM_NInterPro annotationAdd BLAST103
Domaini123 – 449N6_MtaseInterPro annotationAdd BLAST327

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili486 – 506Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1260.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022749, D12N6_MeTrfase_N
IPR038333, D12N6_MeTrfase_N_sf
IPR003356, DNA_methylase_A-5
IPR002052, DNA_methylase_N6_adenine_CS
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12161, HsdM_N, 1 hit
PF02384, N6_Mtase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00092, N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q09050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNNDLVAKL WKLCDNLRDG GVSYQNYVNE LASLLFLKMC KETGQEAEYL 
        60         70         80         90        100
PEGYRWDDLK SRIGQEQLQF YRNLLVHLGA DNQKLVQAVF QNVNTTITQP 
       110        120        130        140        150
KQLTELVSNM DSLDWYNGAH GKSRDDFGDM YEGLLQKNAN ETKSGAGQYF 
       160        170        180        190        200
TPRPLIKTII HLLKPQPREV VQDPAAGTAG FLIEADRYVK SQTNDLDDLD 
       210        220        230        240        250
GDTQDFQIHR AFIGLELVPG TRRLALMNCL LHDIEGNLDH GGAIRLGNTL 
       260        270        280        290        300
GSDGENLPKA HIVATNPPFG SAAGTNITRT FVHPTSNKQL CFMQHIIETL 
       310        320        330        340        350
HPGGRAAVVV PDNVLFEGGK GTDIRRDLMD KCHLHTILRL PTGIFYAQGV 
       360        370        380        390        400
KTNVLFFTKG TVANPHQDKN CTDDVWVYDL RTNMPSFGKR TPFTDEHLQP 
       410        420        430        440        450
FERVYGEDPH GLSPRSEGEW SFNAEETEVA DSEENKNTDQ HLATSRWRKF 
       460        470        480        490        500
TREWIRTTKS DSLDISWLKD KDSIDADNLP EPDVLAAEAM GELVQALGEL 
       510        520 
DALIRELGAS DEADAQRQLL EEAFGGVKE
Length:529
Mass (Da):59,280
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41CB97DCE038375A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L02508 Genomic DNA Translation: AAA23985.1
CP010315 Genomic DNA Translation: AJE58957.1
CP024141 Genomic DNA Translation: AUK02848.1
HG976958 Genomic DNA Translation: CDU40550.1
AAAFMF010000051 Genomic DNA Translation: EAB6863779.1
AAAHEK010000001 Genomic DNA Translation: EAC1930267.1
WKXE01000019 Genomic DNA Translation: MSD74777.1
WSUW01000010 Genomic DNA Translation: MWD13412.1
RRVS01000003 Genomic DNA Translation: RRM14548.1
UGDD01000002 Genomic DNA Translation: STJ56991.1
MTXJ01000052 Genomic DNA Translation: TEZ69638.1
QFTU01000051 Genomic DNA Translation: TYD96157.1

NCBI Reference Sequences

More...RefSeqi		WP_001063206.1, NZ_WSVT01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AJE58957; AJE58957; AC789_1c48080
CDU40550; CDU40550; PGD_03579

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|562.6997.peg.3489

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02508 Genomic DNA Translation: AAA23985.1
CP010315 Genomic DNA Translation: AJE58957.1
CP024141 Genomic DNA Translation: AUK02848.1
HG976958 Genomic DNA Translation: CDU40550.1
AAAFMF010000051 Genomic DNA Translation: EAB6863779.1
AAAHEK010000001 Genomic DNA Translation: EAC1930267.1
WKXE01000019 Genomic DNA Translation: MSD74777.1
WSUW01000010 Genomic DNA Translation: MWD13412.1
RRVS01000003 Genomic DNA Translation: RRM14548.1
UGDD01000002 Genomic DNA Translation: STJ56991.1
MTXJ01000052 Genomic DNA Translation: TEZ69638.1
QFTU01000051 Genomic DNA Translation: TYD96157.1
RefSeqiWP_001063206.1, NZ_WSVT01000001.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

REBASEi101720, M.Eco789ORF48080P
228511, M.Eco029ORF21875P
308147, M.Eco9285ORF21860P
3381, M.EcoBI

Genome annotation databases

EnsemblBacteriaiAJE58957; AJE58957; AC789_1c48080
CDU40550; CDU40550; PGD_03579
PATRICifig|562.6997.peg.3489

Family and domain databases

Gene3Di1.20.1260.30, 1 hit
InterProiView protein in InterPro
IPR022749, D12N6_MeTrfase_N
IPR038333, D12N6_MeTrfase_N_sf
IPR003356, DNA_methylase_A-5
IPR002052, DNA_methylase_N6_adenine_CS
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF12161, HsdM_N, 1 hit
PF02384, N6_Mtase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092, N6_MTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ09050_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09050
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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