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UniProtKB - Q09028 (RBBP4_HUMAN)

Entry version 227 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Histone-binding protein RBBP4

Gene

RBBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processCell cycle, DNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q09028

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133, G0 and Early G1
R-HSA-156711, Polo-like kinase mediated events
R-HSA-212300, PRC2 methylates histones and DNA
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-3214815, HDACs deacetylate histones
R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69205, G1/S-Specific Transcription
R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-8953750, Transcriptional Regulation by E2F6
R-HSA-9609690, HCMV Early Events
R-HSA-9679191, Potential therapeutics for SARS
R-HSA-9710421, Defective pyroptosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q09028

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q09028

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-binding protein RBBP4
Alternative name(s):
Chromatin assembly factor 1 subunit C
Short name:
CAF-1 subunit C
Chromatin assembly factor I p48 subunit
Short name:
CAF-I 48 kDa subunit
Short name:
CAF-I p48
Nucleosome-remodeling factor subunit RBAP48
Retinoblastoma-binding protein 4
Short name:
RBBP-4
Retinoblastoma-binding protein p48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBBP4
Synonyms:RBAP48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9887, RBBP4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602923, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q09028

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000162521

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5928

Open Targets

More...OpenTargetsi		ENSG00000162521

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34251

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q09028, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3137287
CHEMBL3301388

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBBP4

Domain mapping of disease mutations (DMDM)

More...DMDMi		1172846

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000511862 – 425Histone-binding protein RBBP4Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei4N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residuei110PhosphoserineCombined sources1
Modified residuei160N6-acetyllysine; alternateBy similarity1
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q09028

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q09028

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q09028

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q09028

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q09028

PeptideAtlas

More...PeptideAtlasi		Q09028

PRoteomics IDEntifications database

More...PRIDEi		Q09028

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58712 [Q09028-1]
58713 [Q09028-2]
58714 [Q09028-3]
58715 [Q09028-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q09028, 1 site, 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q09028

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q09028

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q09028

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162521, Expressed in subventricular zone (outer) (primate) and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q09028, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q09028, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162521, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SUV39H1 and HDAC7 (By similarity). Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (PubMed:8858152, PubMed:9427644). Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A (PubMed:8858152). Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7 (PubMed:9150135). The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex (PubMed:9150135, PubMed:9651585, PubMed:11118440, PubMed:11784859). The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex) (PubMed:9790534, PubMed:10444591, PubMed:11102443). The NuRD complex may also interact with MBD3L1 and MBD3L2 (PubMed:15456747, PubMed:15701600).

Interacts with MTA1 (PubMed:12920132).

Component of the PRC2 complex, which consists of the core subunits EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:12435631, PubMed:12351676, PubMed:29499137, PubMed:31959557).

Forms a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (PubMed:29499137).

Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19; PHF19 stabilizes the dimeric structure which enhances PRC2 interaction with chromatin (PubMed:31959557).

Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1 (isoform 2), BPTF, RBBP4 and RBBP7 (PubMed:14609955, PubMed:15310751). Within the complex interacts with isoform 2 of SMARCA1 (PubMed:14609955, PubMed:15310751).

Component of the BPFT-SMARCA1 complex at least composed of SMARCA1 (isoform 1), BPFT, RBBP4 and RBBP7; the complex is catalytically inactive and does not remodel chromatin (PubMed:15310751). Within the complex interacts with isoform 1 of SMARCA1 (PubMed:15310751).

Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (PubMed:12198550).

Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10734134).

Interacts with SPEN/MINT (PubMed:11331609).

Interacts with BRCA1 (PubMed:10220405).

Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP (PubMed:10866654).

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (PubMed:17671431, PubMed:17531812). The complex exists in quiescent cells where it represses cell cycle-dependent genes (PubMed:17671431, PubMed:17531812). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (PubMed:17671431, PubMed:17531812).

Interacts with PHF6 (PubMed:24554700).

Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity).

Interacts with ERCC6 (PubMed:26030138).

By similarity28 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111863, 317 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3321, SIN3A histone deacetylase complex
CPX-3322, SIN3B histone deacetylase complex
CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant
CPX-569, Chromatin assembly factor 1 complex
CPX-688, NuRF chromatin remodeling complex
CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q09028

Database of interacting proteins

More...DIPi		DIP-33495N

Protein interaction database and analysis system

More...IntActi		Q09028, 170 interactors

Molecular INTeraction database

More...MINTi		Q09028

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362592

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q09028

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q09028, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q09028

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q09028

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati122 – 155WD 1Add BLAST34
Repeati175 – 206WD 2Add BLAST32
Repeati225 – 256WD 3Add BLAST32
Repeati271 – 302WD 4Add BLAST32
Repeati315 – 346WD 5Add BLAST32
Repeati372 – 403WD 6Add BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0264, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153375

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020445_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q09028

Identification of Orthologs from Complete Genome Data

More...OMAi		HLADFSW

Database of Orthologous Groups

More...OrthoDBi		831322at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q09028

TreeFam database of animal gene trees

More...TreeFami		TF106485

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00317

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020472, G-protein_beta_WD-40_rep
IPR022052, Histone-bd_RBBP4_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12265, CAF1C_H4-bd, 1 hit
PF00400, WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00320, GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00678, WD_REPEATS_1, 3 hits
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q09028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL 
        60         70         80         90        100
PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS 
       110        120        130        140        150
EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL 
       160        170        180        190        200
VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH 
       210        220        230        240        250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ 
       260        270        280        290        300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL 
       310        320        330        340        350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI 
       360        370        380        390        400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ 
       410        420 
VWQMAENIYN DEDPEGSVDP EGQGS
Length:425
Mass (Da):47,656
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB71E2D55A444C360
GO
Isoform 2 (identifier: Q09028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: Missing.

Show »
Length:424
Mass (Da):47,585
Checksum:i52055B5C74BCF3D8
GO
Isoform 3 (identifier: Q09028-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-425: AENIYNDEDPEGSVDPEGQGS → ELVLDH

Show »
Length:410
Mass (Da):46,158
Checksum:i59B630D6055A70B2
GO
Isoform 4 (identifier: Q09028-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:390
Mass (Da):43,482
Checksum:iA61A43F6AC30C8CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDK2H0YDK2_HUMAN
Histone-binding protein RBBP4
RBBP4
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEU5H0YEU5_HUMAN
Histone-binding protein RBBP4
RBBP4
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF10H0YF10_HUMAN
Histone-binding protein RBBP4
RBBP4
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCT5H0YCT5_HUMAN
Histone-binding protein RBBP4
RBBP4
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPP3C9JPP3_HUMAN
Histone-binding protein RBBP4
RBBP4
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PND5E9PND5_HUMAN
Histone-binding protein RBBP4
RBBP4
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIC4E9PIC4_HUMAN
Histone-binding protein RBBP4
RBBP4
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNS2E9PNS2_HUMAN
Histone-binding protein RBBP4
RBBP4
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNS6E9PNS6_HUMAN
Histone-binding protein RBBP4
RBBP4
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61F → G in AAH15123 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0400871 – 35Missing in isoform 4. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0400887Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_040089405 – 425AENIY…EGQGS → ELVLDH in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X74262 mRNA Translation: CAA52321.1
X71810 mRNA Translation: CAA50685.1
BT007309 mRNA Translation: AAP35973.1
AK299251 mRNA Translation: BAG61282.1
AK312571 mRNA Translation: BAG35466.1
AK222779 mRNA Translation: BAD96499.1
AC114489 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07513.1
CH471059 Genomic DNA Translation: EAX07514.1
BC003092 mRNA Translation: AAH03092.1
BC015123 mRNA Translation: AAH15123.1
BC053904 mRNA Translation: AAH53904.1
BC075836 mRNA Translation: AAH75836.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS366.1 [Q09028-1]
CCDS44105.1 [Q09028-2]
CCDS44106.1 [Q09028-4]

Protein sequence database of the Protein Information Resource

More...PIRi		S36112

NCBI Reference Sequences

More...RefSeqi		NP_001128727.1, NM_001135255.1 [Q09028-2]
NP_001128728.1, NM_001135256.1 [Q09028-4]
NP_005601.1, NM_005610.2 [Q09028-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373485; ENSP00000362584; ENSG00000162521 [Q09028-3]
ENST00000373493; ENSP00000362592; ENSG00000162521 [Q09028-1]
ENST00000414241; ENSP00000398242; ENSG00000162521 [Q09028-2]
ENST00000458695; ENSP00000396057; ENSG00000162521 [Q09028-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5928

UCSC genome browser

More...UCSCi		uc001bvr.3, human [Q09028-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74262 mRNA Translation: CAA52321.1
X71810 mRNA Translation: CAA50685.1
BT007309 mRNA Translation: AAP35973.1
AK299251 mRNA Translation: BAG61282.1
AK312571 mRNA Translation: BAG35466.1
AK222779 mRNA Translation: BAD96499.1
AC114489 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07513.1
CH471059 Genomic DNA Translation: EAX07514.1
BC003092 mRNA Translation: AAH03092.1
BC015123 mRNA Translation: AAH15123.1
BC053904 mRNA Translation: AAH53904.1
BC075836 mRNA Translation: AAH75836.1
CCDSiCCDS366.1 [Q09028-1]
CCDS44105.1 [Q09028-2]
CCDS44106.1 [Q09028-4]
PIRiS36112
RefSeqiNP_001128727.1, NM_001135255.1 [Q09028-2]
NP_001128728.1, NM_001135256.1 [Q09028-4]
NP_005601.1, NM_005610.2 [Q09028-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XU7X-ray1.90A/B1-425[»]
3GFCX-ray2.30A1-425[»]
4PBYX-ray2.50A/B1-425[»]
4PBZX-ray2.15A1-425[»]
4PC0X-ray2.50A/B1-425[»]
4R7AX-ray1.85B1-425[»]
5FXYX-ray3.20A/C/E/G1-425[»]
5VTBX-ray2.40A1-425[»]
5WAIX-ray2.90A/E1-425[»]
5WAKX-ray3.20A1-425[»]
5XWRX-ray2.69A/B1-425[»]
5XXQX-ray1.90A/B1-425[»]
5Y1UX-ray2.14A/B1-425[»]
6BW3X-ray2.20A/C1-425[»]
6BW4X-ray2.00A/C1-425[»]
6C23electron microscopy3.90N1-425[»]
6C24electron microscopy3.50N1-425[»]
6G16X-ray2.80A/C/E/G1-425[»]
6NQ3X-ray2.89A/E1-425[»]
6WKRelectron microscopy3.50N1-425[»]
6ZRCX-ray2.60A/B1-425[»]
6ZRDX-ray2.50A/B1-425[»]
7AOAelectron microscopy19.40F/G1-425[»]
7KSOelectron microscopy3.90D1-425[»]
7KSRelectron microscopy4.10D1-425[»]
7KTPelectron microscopy4.80D1-425[»]
7M40X-ray1.88A/B1-425[»]
SMRiQ09028
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111863, 317 interactors
ComplexPortaliCPX-3321, SIN3A histone deacetylase complex
CPX-3322, SIN3B histone deacetylase complex
CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant
CPX-569, Chromatin assembly factor 1 complex
CPX-688, NuRF chromatin remodeling complex
CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ09028
DIPiDIP-33495N
IntActiQ09028, 170 interactors
MINTiQ09028
STRINGi9606.ENSP00000362592

Chemistry databases

BindingDBiQ09028
ChEMBLiCHEMBL3137287
CHEMBL3301388

PTM databases

GlyGeniQ09028, 1 site, 2 O-linked glycans (1 site)
iPTMnetiQ09028
PhosphoSitePlusiQ09028
SwissPalmiQ09028

Genetic variation databases

BioMutaiRBBP4
DMDMi1172846

Proteomic databases

EPDiQ09028
jPOSTiQ09028
MassIVEiQ09028
MaxQBiQ09028
PaxDbiQ09028
PeptideAtlasiQ09028
PRIDEiQ09028
ProteomicsDBi58712 [Q09028-1]
58713 [Q09028-2]
58714 [Q09028-3]
58715 [Q09028-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3343, 478 antibodies

The DNASU plasmid repository

More...DNASUi		5928

Genome annotation databases

EnsembliENST00000373485; ENSP00000362584; ENSG00000162521 [Q09028-3]
ENST00000373493; ENSP00000362592; ENSG00000162521 [Q09028-1]
ENST00000414241; ENSP00000398242; ENSG00000162521 [Q09028-2]
ENST00000458695; ENSP00000396057; ENSG00000162521 [Q09028-4]
GeneIDi5928
KEGGihsa:5928
UCSCiuc001bvr.3, human [Q09028-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5928
DisGeNETi5928

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBBP4
HGNCiHGNC:9887, RBBP4
HPAiENSG00000162521, Low tissue specificity
MIMi602923, gene
neXtProtiNX_Q09028
OpenTargetsiENSG00000162521
PharmGKBiPA34251
VEuPathDBiHostDB:ENSG00000162521

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0264, Eukaryota
GeneTreeiENSGT00940000153375
HOGENOMiCLU_020445_3_1_1
InParanoidiQ09028
OMAiHLADFSW
OrthoDBi831322at2759
PhylomeDBiQ09028
TreeFamiTF106485

Enzyme and pathway databases

PathwayCommonsiQ09028
ReactomeiR-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133, G0 and Early G1
R-HSA-156711, Polo-like kinase mediated events
R-HSA-212300, PRC2 methylates histones and DNA
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-3214815, HDACs deacetylate histones
R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69205, G1/S-Specific Transcription
R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-8953750, Transcriptional Regulation by E2F6
R-HSA-9609690, HCMV Early Events
R-HSA-9679191, Potential therapeutics for SARS
R-HSA-9710421, Defective pyroptosis
SignaLinkiQ09028
SIGNORiQ09028

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5928, 737 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBBP4, human
EvolutionaryTraceiQ09028

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RBBP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5928
PharosiQ09028, Tbio

Protein Ontology

More...PROi		PR:Q09028
RNActiQ09028, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162521, Expressed in subventricular zone (outer) (primate) and 225 other tissues
ExpressionAtlasiQ09028, baseline and differential
GenevisibleiQ09028, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
IDEALiIID00317
InterProiView protein in InterPro
IPR020472, G-protein_beta_WD-40_rep
IPR022052, Histone-bd_RBBP4_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265, CAF1C_H4-bd, 1 hit
PF00400, WD40, 5 hits
PRINTSiPR00320, GPROTEINBRPT
SMARTiView protein in SMART
SM00320, WD40, 6 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 3 hits
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBBP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09028
Secondary accession number(s): B2R6G9
, B4DRH0, D3DPQ3, P31149, Q53H02, Q96BV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 227 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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