RBBP4

Functionⁱ

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.1 Publication

GO - Molecular functionⁱ

histone binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 17827154
histone deacetylase activity Source: Reactome
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17827154

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP-dependent chromatin remodeling
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 16217013
cell cycle Source: UniProtKB-KW
CENP-A containing nucleosome assembly Source: Reactome
chromatin assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 8858152
chromatin remodeling
Source: HGNC
Inferred from direct assayⁱ
- 14609955
DNA replication Source: UniProtKB-KW
DNA replication-dependent nucleosome assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 14718166
DNA replication-independent nucleosome assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 14718166
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8350924
negative regulation of G0 to G1 transition Source: Reactome
negative regulation of gene expression, epigenetic Source: Reactome
regulation of cell cycle Source: Reactome
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Repressor
Biological process	Cell cycle, DNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133 G0 and Early G1 R-HSA-156711 Polo-like kinase mediated events R-HSA-212300 PRC2 methylates histones and DNA R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-3214815 HDACs deacetylate histones R-HSA-3214841 PKMTs methylate histone lysines R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-6804758 Regulation of TP53 Activity through Acetylation R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-8943724 Regulation of PTEN gene transcription R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkⁱ	Q09028
SIGNORⁱ	Q09028

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone-binding protein RBBP4 Alternative name(s): Chromatin assembly factor 1 subunit C Short name: CAF-1 subunit C Chromatin assembly factor I p48 subunit Short name: CAF-I 48 kDa subunit Short name: CAF-I p48 Nucleosome-remodeling factor subunit RBAP48 Retinoblastoma-binding protein 4 Short name: RBBP-4 Retinoblastoma-binding protein p48
Gene namesⁱ	Name:RBBP4 Synonyms:RBAP48
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162521.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9887 RBBP4
MIMⁱ	602923 gene
neXtProtⁱ	NX_Q09028

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5928
Open Targets More...OpenTargetsⁱ	ENSG00000162521
PharmGKBⁱ	PA34251

Chemistry databases

ChEMBLⁱ	CHEMBL3137287

ChEMBLⁱ

CHEMBL3137287

Polymorphism and mutation databases

BioMutaⁱ	RBBP4
DMDMⁱ	1172846

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000051186	2 – 425	Histone-binding protein RBBP4Add BLAST		424

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	4	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	4	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	4	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residueⁱ	110	PhosphoserineCombined sources	1
Modified residueⁱ	160	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	160	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	355	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q09028
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q09028
PaxDbⁱ	Q09028
PeptideAtlas More...PeptideAtlasⁱ	Q09028
PRIDEⁱ	Q09028
ProteomicsDBⁱ	58712 58713 [Q09028-2] 58714 [Q09028-3] 58715 [Q09028-4]

PTM databases

iPTMnetⁱ	Q09028
PhosphoSitePlusⁱ	Q09028
SwissPalmⁱ	Q09028

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162521 Expressed in 209 organ(s), highest expression level in lung
CleanExⁱ	HS_RBBP4
ExpressionAtlasⁱ	Q09028 baseline and differential
Genevisibleⁱ	Q09028 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006264 HPA060710 HPA060724

HPAⁱ

CAB006264
HPA060710
HPA060724

Interactionⁱ

Subunit structureⁱ

Interacts with SUV39H1 and HDAC7 (By similarity). Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with SPEN/MINT. Interacts with BRCA1. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with PHF6 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity).By similarity25 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	Q9BRL8	3	EBI-620823,EBI-10297046
HAT1	O14929	3	EBI-620823,EBI-2339359
HDAC1	Q13547	7	EBI-620823,EBI-301834
MTA1	Q13330	8	EBI-620823,EBI-714236
ZFPM1	Q8IX07	4	EBI-620823,EBI-3942619

GO - Molecular functionⁱ

histone binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 17827154
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17827154

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111863, 198 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant CPX-569 Chromatin assembly factor 1 complex CPX-688 NuRF chromatin remodelling complex CPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMⁱ	Q09028
Database of interacting proteins More...DIPⁱ	DIP-33495N
IntActⁱ	Q09028, 123 interactors
Molecular INTeraction database More...MINTⁱ	Q09028
STRINGⁱ	9606.ENSP00000362592

Chemistry databases

BindingDBⁱ

Q09028

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 11	Combined sources	4
Turnⁱ	12 – 14	Combined sources	3
Helixⁱ	16 – 31	Combined sources	16
Beta strandⁱ	32 – 39	Combined sources	8
Beta strandⁱ	47 – 54	Combined sources	8
Beta strandⁱ	60 – 69	Combined sources	10
Beta strandⁱ	73 – 75	Combined sources	3
Beta strandⁱ	77 – 87	Combined sources	11
Helixⁱ	95 – 98	Combined sources	4
Turnⁱ	100 – 103	Combined sources	4
Beta strandⁱ	115 – 125	Combined sources	11
Beta strandⁱ	128 – 133	Combined sources	6
Beta strandⁱ	136 – 143	Combined sources	8
Beta strandⁱ	145 – 147	Combined sources	3
Beta strandⁱ	149 – 153	Combined sources	5
Helixⁱ	154 – 156	Combined sources	3
Beta strandⁱ	170 – 174	Combined sources	5
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	192 – 196	Combined sources	5
Beta strandⁱ	197 – 200	Combined sources	4
Beta strandⁱ	202 – 206	Combined sources	5
Helixⁱ	207 – 209	Combined sources	3
Helixⁱ	211 – 213	Combined sources	3
Beta strandⁱ	216 – 218	Combined sources	3
Beta strandⁱ	220 – 223	Combined sources	4
Beta strandⁱ	230 – 235	Combined sources	6
Beta strandⁱ	242 – 247	Combined sources	6
Beta strandⁱ	250 – 256	Combined sources	7
Beta strandⁱ	262 – 264	Combined sources	3
Beta strandⁱ	266 – 270	Combined sources	5
Beta strandⁱ	276 – 281	Combined sources	6
Beta strandⁱ	288 – 293	Combined sources	6
Beta strandⁱ	296 – 302	Combined sources	7
Helixⁱ	303 – 305	Combined sources	3
Beta strandⁱ	306 – 308	Combined sources	3
Beta strandⁱ	310 – 314	Combined sources	5
Beta strandⁱ	320 – 325	Combined sources	6
Beta strandⁱ	332 – 337	Combined sources	6
Beta strandⁱ	342 – 346	Combined sources	5
Helixⁱ	347 – 349	Combined sources	3
Helixⁱ	358 – 360	Combined sources	3
Beta strandⁱ	366 – 370	Combined sources	5
Beta strandⁱ	377 – 382	Combined sources	6
Beta strandⁱ	384 – 386	Combined sources	3
Beta strandⁱ	389 – 394	Combined sources	6
Beta strandⁱ	397 – 404	Combined sources	8
Helixⁱ	406 – 409	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q09028
SMRⁱ	Q09028
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q09028

EvolutionaryTraceⁱ

Q09028

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	122 – 155	WD 1Add BLAST	34
Repeatⁱ	175 – 206	WD 2Add BLAST	32
Repeatⁱ	225 – 256	WD 3Add BLAST	32
Repeatⁱ	271 – 302	WD 4Add BLAST	32
Repeatⁱ	315 – 346	WD 5Add BLAST	32
Repeatⁱ	372 – 403	WD 6Add BLAST	32

Sequence similaritiesⁱ

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0264 Eukaryota ENOG410XNU9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00570000079069
HOVERGENⁱ	HBG053236
InParanoidⁱ	Q09028
KEGG Orthology (KO) More...KOⁱ	K10752
OMAⁱ	TNHLADF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A20
PhylomeDBⁱ	Q09028
TreeFamⁱ	TF106485

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR022052 Histone-bd_RBBP4_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12265 CAF1C_H4-bd, 1 hit PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 6 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q09028-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL 
        60         70         80         90        100
PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS 
       110        120        130        140        150
EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL 
       160        170        180        190        200
VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH 
       210        220        230        240        250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ 
       260        270        280        290        300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL 
       310        320        330        340        350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI 
       360        370        380        390        400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ 
       410        420 
VWQMAENIYN DEDPEGSVDP EGQGS

Length:425

Mass (Da):47,656

Last modified:January 23, 2007 - v3

Checksum:ⁱB71E2D55A444C360

GO

Isoform 2 (identifier: Q09028-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
7-7: Missing.

« Hide

        10         20         30         40         50
MADKEAFDDA VEERVINEEY KIWKKNTPFL YDLVMTHALE WPSLTAQWLP 
        60         70         80         90        100
DVTRPEGKDF SIHRLVLGTH TSDEQNHLVI ASVQLPNDDA QFDASHYDSE 
       110        120        130        140        150
KGEFGGFGSV SGKIEIEIKI NHEGEVNRAR YMPQNPCIIA TKTPSSDVLV 
       160        170        180        190        200
FDYTKHPSKP DPSGECNPDL RLRGHQKEGY GLSWNPNLSG HLLSASDDHT 
       210        220        230        240        250
ICLWDISAVP KEGKVVDAKT IFTGHTAVVE DVSWHLLHES LFGSVADDQK 
       260        270        280        290        300
LMIWDTRSNN TSKPSHSVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW 
       310        320        330        340        350
DLRNLKLKLH SFESHKDEIF QVQWSPHNET ILASSGTDRR LNVWDLSKIG 
       360        370        380        390        400
EEQSPEDAED GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQV 
       410        420 
WQMAENIYND EDPEGSVDPE GQGS

Note: No experimental confirmation available.

Show »

Length:424

Mass (Da):47,585

Checksum:ⁱ52055B5C74BCF3D8

GO

Isoform 3 (identifier: Q09028-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
405-425: AENIYNDEDPEGSVDPEGQGS → ELVLDH

« Hide

        10         20         30         40         50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL 
        60         70         80         90        100
PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS 
       110        120        130        140        150
EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL 
       160        170        180        190        200
VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH 
       210        220        230        240        250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ 
       260        270        280        290        300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL 
       310        320        330        340        350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI 
       360        370        380        390        400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ 
       410
VWQMELVLDH

Note: No experimental confirmation available.

Show »

Length:410

Mass (Da):46,158

Checksum:ⁱ59B630D6055A70B2

GO

Isoform 4 (identifier: Q09028-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-35: Missing.

« Hide

        10         20         30         40         50
MTHALEWPSL TAQWLPDVTR PEGKDFSIHR LVLGTHTSDE QNHLVIASVQ 
        60         70         80         90        100
LPNDDAQFDA SHYDSEKGEF GGFGSVSGKI EIEIKINHEG EVNRARYMPQ 
       110        120        130        140        150
NPCIIATKTP SSDVLVFDYT KHPSKPDPSG ECNPDLRLRG HQKEGYGLSW 
       160        170        180        190        200
NPNLSGHLLS ASDDHTICLW DISAVPKEGK VVDAKTIFTG HTAVVEDVSW 
       210        220        230        240        250
HLLHESLFGS VADDQKLMIW DTRSNNTSKP SHSVDAHTAE VNCLSFNPYS 
       260        270        280        290        300
EFILATGSAD KTVALWDLRN LKLKLHSFES HKDEIFQVQW SPHNETILAS 
       310        320        330        340        350
SGTDRRLNVW DLSKIGEEQS PEDAEDGPPE LLFIHGGHTA KISDFSWNPN 
       360        370        380        390
EPWVICSVSE DNIMQVWQMA ENIYNDEDPE GSVDPEGQGS

Note: No experimental confirmation available.

Show »

Length:390

Mass (Da):43,482

Checksum:ⁱA61A43F6AC30C8CE

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YDK2	H0YDK2_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	262	Annotation score:
H0YEU5	H0YEU5_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	167	Annotation score:
H0YF10	H0YF10_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	207	Annotation score:
H0YCT5	H0YCT5_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	180	Annotation score:
C9JPP3	C9JPP3_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	87	Annotation score:
E9PNS2	E9PNS2_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	62	Annotation score:
E9PNS6	E9PNS6_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	104	Annotation score:
E9PIC4	E9PIC4_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	87	Annotation score:
E9PND5	E9PND5_HUMAN	Histone-binding protein RBBP4 Histone-binding protein RBBP4	RBBP4	68	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	61	F → G in AAH15123 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040087	1 – 35	Missing in isoform 4. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_040088	7	Missing in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_040089	405 – 425	AENIY…EGQGS → ELVLDH in isoform 3. 1 PublicationAdd BLAST	21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X74262 mRNA Translation: CAA52321.1 X71810 mRNA Translation: CAA50685.1 BT007309 mRNA Translation: AAP35973.1 AK299251 mRNA Translation: BAG61282.1 AK312571 mRNA Translation: BAG35466.1 AK222779 mRNA Translation: BAD96499.1 AC114489 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07513.1 CH471059 Genomic DNA Translation: EAX07514.1 BC003092 mRNA Translation: AAH03092.1 BC015123 mRNA Translation: AAH15123.1 BC053904 mRNA Translation: AAH53904.1 BC075836 mRNA Translation: AAH75836.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS366.1 [Q09028-1] CCDS44105.1 [Q09028-2] CCDS44106.1 [Q09028-4]
PIRⁱ	S36112
NCBI Reference Sequences More...RefSeqⁱ	NP_001128727.1, NM_001135255.1 [Q09028-2] NP_001128728.1, NM_001135256.1 [Q09028-4] NP_005601.1, NM_005610.2 [Q09028-1]
UniGeneⁱ	Hs.16003

Genome annotation databases

Ensemblⁱ	ENST00000373485; ENSP00000362584; ENSG00000162521 [Q09028-3] ENST00000373493; ENSP00000362592; ENSG00000162521 [Q09028-1] ENST00000414241; ENSP00000398242; ENSG00000162521 [Q09028-2] ENST00000458695; ENSP00000396057; ENSG00000162521 [Q09028-4]
GeneIDⁱ	5928
KEGGⁱ	hsa:5928
UCSC genome browser More...UCSCⁱ	uc001bvr.3 human [Q09028-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q09028	Histone-binding protein RBBP4		BOVIN		425	UniRef100_Q09028
Histone-binding protein RBBP4		MOUSE		425
Uncharacterized protein		MACMU		103
Uncharacterized protein		MANLE		419
Uncharacterized protein		MACFA		103
+82
Q09028-2	Uncharacterized protein		MACMU		424	UniRef100_A0A1D5RC03
histone-binding protein RBBP4 isoform X2		ERIEU		424
histone-binding protein RBBP4 isoform X2		Enhydra lutris kenyoni		424
RBBP4 isoform 6		PONAB		424
RBBP4 isoform 1		PANTR		424
+2
Q09028-3	Uncharacterized protein		MACMU		410	UniRef100_F6RJL6
Uncharacterized protein		CALJA		410
RBBP4 isoform 2		PONAB		410
RBBP4 isoform 10		PANTR		410
Uncharacterized protein		AOTNA		410
+6

Protein	Similar proteins		Species	Score	Length	Source
Q09028	Histone-binding protein RBBP4		BOVIN		425	UniRef90_Q09028
Histone-binding protein RBBP4		MOUSE		425
Uncharacterized protein		MACMU		103
Uncharacterized protein		MANLE		419
Uncharacterized protein		MACFA		103
+150
Q09028-3	Histone-binding protein RBBP7		XENTR		425	UniRef90_Q6P315
Histone-binding protein RBBP7		XENLA		425
Histone-binding protein RBBP4-like (Fragment)		Asian bonytongue		448
Histone-binding protein RBBP7		CALMI		443
Histone-binding protein RBBP4 (Fragment)		OPHHA		437
+97

Protein	Similar proteins		Species	Score	Length	Source
Q09028	Histone-binding protein RBBP4		BOVIN		425	UniRef50_Q09028
Histone-binding protein RBBP4		MOUSE		425
Histone-binding protein RBBP7		DANRE		426
Histone-binding protein RBBP7		XENTR		425
Histone-binding protein RBBP7		XENLA		425
+351

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X74262 mRNA Translation: CAA52321.1 X71810 mRNA Translation: CAA50685.1 BT007309 mRNA Translation: AAP35973.1 AK299251 mRNA Translation: BAG61282.1 AK312571 mRNA Translation: BAG35466.1 AK222779 mRNA Translation: BAD96499.1 AC114489 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07513.1 CH471059 Genomic DNA Translation: EAX07514.1 BC003092 mRNA Translation: AAH03092.1 BC015123 mRNA Translation: AAH15123.1 BC053904 mRNA Translation: AAH53904.1 BC075836 mRNA Translation: AAH75836.1
CCDSⁱ	CCDS366.1 [Q09028-1] CCDS44105.1 [Q09028-2] CCDS44106.1 [Q09028-4]
PIRⁱ	S36112
RefSeqⁱ	NP_001128727.1, NM_001135255.1 [Q09028-2] NP_001128728.1, NM_001135256.1 [Q09028-4] NP_005601.1, NM_005610.2 [Q09028-1]
UniGeneⁱ	Hs.16003

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2XU7	X-ray	1.90	A/B	1-425	[»]
	3GFC	X-ray	2.30	A	1-425	[»]
	4PBY	X-ray	2.50	A/B	1-425	[»]
	4PBZ	X-ray	2.15	A	1-425	[»]
	4PC0	X-ray	2.50	A/B	1-425	[»]
	4R7A	X-ray	1.85	B	1-425	[»]
	5FXY	X-ray	3.20	A/C/E/G	1-425	[»]
	5VTB	X-ray	2.40	A	1-425	[»]
	5WAI	X-ray	2.90	A/E	1-425	[»]
	5WAK	X-ray	3.20	A	1-425	[»]
	5XWR	X-ray	2.69	A/B	1-425	[»]
	5XXQ	X-ray	1.90	A/B	1-425	[»]
	5Y1U	X-ray	2.14	A/B	1-425	[»]
	6BW3	X-ray	2.20	A/C	1-425	[»]
	6BW4	X-ray	2.00	A/C	1-425	[»]
	6C23	electron microscopy	3.90	N	1-425	[»]
	6C24	electron microscopy	3.50	N	1-425	[»]
	6G16	X-ray	2.80	A/C/E/G	1-425	[»]
ProteinModelPortalⁱ	Q09028
SMRⁱ	Q09028
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111863, 198 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant CPX-569 Chromatin assembly factor 1 complex CPX-688 NuRF chromatin remodelling complex CPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMⁱ	Q09028
DIPⁱ	DIP-33495N
IntActⁱ	Q09028, 123 interactors
MINTⁱ	Q09028
STRINGⁱ	9606.ENSP00000362592

Chemistry databases

BindingDBⁱ	Q09028
ChEMBLⁱ	CHEMBL3137287

PTM databases

iPTMnetⁱ	Q09028
PhosphoSitePlusⁱ	Q09028
SwissPalmⁱ	Q09028

Polymorphism and mutation databases

BioMutaⁱ	RBBP4
DMDMⁱ	1172846

Proteomic databases

EPDⁱ	Q09028
MaxQBⁱ	Q09028
PaxDbⁱ	Q09028
PeptideAtlasⁱ	Q09028
PRIDEⁱ	Q09028
ProteomicsDBⁱ	58712 58713 [Q09028-2] 58714 [Q09028-3] 58715 [Q09028-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5928
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373485; ENSP00000362584; ENSG00000162521 [Q09028-3] ENST00000373493; ENSP00000362592; ENSG00000162521 [Q09028-1] ENST00000414241; ENSP00000398242; ENSG00000162521 [Q09028-2] ENST00000458695; ENSP00000396057; ENSG00000162521 [Q09028-4]
GeneIDⁱ	5928
KEGGⁱ	hsa:5928
UCSCⁱ	uc001bvr.3 human [Q09028-1]

Organism-specific databases

CTDⁱ	5928
DisGeNETⁱ	5928
EuPathDBⁱ	HostDB:ENSG00000162521.18
GeneCardsⁱ	RBBP4
HGNCⁱ	HGNC:9887 RBBP4
HPAⁱ	CAB006264 HPA060710 HPA060724
MIMⁱ	602923 gene
neXtProtⁱ	NX_Q09028
OpenTargetsⁱ	ENSG00000162521
PharmGKBⁱ	PA34251
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0264 Eukaryota ENOG410XNU9 LUCA
GeneTreeⁱ	ENSGT00570000079069
HOVERGENⁱ	HBG053236
InParanoidⁱ	Q09028
KOⁱ	K10752
OMAⁱ	TNHLADF
OrthoDBⁱ	EOG091G0A20
PhylomeDBⁱ	Q09028
TreeFamⁱ	TF106485

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133 G0 and Early G1 R-HSA-156711 Polo-like kinase mediated events R-HSA-212300 PRC2 methylates histones and DNA R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-3214815 HDACs deacetylate histones R-HSA-3214841 PKMTs methylate histone lysines R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-6804758 Regulation of TP53 Activity through Acetylation R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-8943724 Regulation of PTEN gene transcription R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkⁱ	Q09028
SIGNORⁱ	Q09028

Miscellaneous databases

ChiTaRSⁱ	RBBP4 human
EvolutionaryTraceⁱ	Q09028
GeneWikiⁱ	RBBP4
GenomeRNAiⁱ	5928
Protein Ontology More...PROⁱ	PR:Q09028
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162521 Expressed in 209 organ(s), highest expression level in lung
CleanExⁱ	HS_RBBP4
ExpressionAtlasⁱ	Q09028 baseline and differential
Genevisibleⁱ	Q09028 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR022052 Histone-bd_RBBP4_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF12265 CAF1C_H4-bd, 1 hit PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 6 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBBP4_HUMAN
Accessionⁱ	Q09028Primary (citable) accession number: Q09028 Secondary accession number(s): B2R6G9 , B4DRH0, D3DPQ3, P31149, Q53H02, Q96BV9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 205 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q09028 (RBBP4_HUMAN)

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Histone-binding protein RBBP4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

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Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Keywords - Technical termⁱ