UniProtKB - Q09028 (RBBP4_HUMAN)
Histone-binding protein RBBP4
RBBP4
Functioni
GO - Molecular functioni
- histone binding Source: BHF-UCL
- histone deacetylase binding Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- ATP-dependent chromatin remodeling Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- CENP-A containing nucleosome assembly Source: Reactome
- chromatin assembly Source: UniProtKB
- chromatin remodeling Source: HGNC-UCL
- DNA replication Source: UniProtKB-KW
- DNA replication-dependent nucleosome assembly Source: UniProtKB
- DNA replication-independent nucleosome assembly Source: UniProtKB
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of G0 to G1 transition Source: Reactome
- negative regulation of gene expression, epigenetic Source: Reactome
- regulation of cell cycle Source: Reactome
- regulation of signal transduction by p53 class mediator Source: Reactome
- response to growth hormone Source: Ensembl
- viral life cycle Source: Reactome
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Cell cycle, DNA replication, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q09028 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133, G0 and Early G1 R-HSA-156711, Polo-like kinase mediated events R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214841, PKMTs methylate histone lysines R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-8953750, Transcriptional Regulation by E2F6 R-HSA-9609690, HCMV Early Events R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q09028 |
SIGNORi | Q09028 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-binding protein RBBP4Alternative name(s): Chromatin assembly factor 1 subunit C Short name: CAF-1 subunit C Chromatin assembly factor I p48 subunit Short name: CAF-I 48 kDa subunit Short name: CAF-I p48 Nucleosome-remodeling factor subunit RBAP48 Retinoblastoma-binding protein 4 Short name: RBBP-4 Retinoblastoma-binding protein p48 |
Gene namesi | Name:RBBP4 Synonyms:RBAP48 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9887, RBBP4 |
MIMi | 602923, gene |
neXtProti | NX_Q09028 |
VEuPathDBi | HostDB:ENSG00000162521.18 |
Subcellular locationi
Nucleus
- Nucleus 5 Publications
Note: Localizes to chromatin as part of the PRC2 complex.1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- ESC/E(Z) complex Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: HGNC-UCL
- NuRD complex Source: UniProtKB
- NURF complex Source: UniProtKB
- Sin3 complex Source: BHF-UCL
Other locations
- CAF-1 complex Source: UniProtKB
- chromatin Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5928 |
OpenTargetsi | ENSG00000162521 |
PharmGKBi | PA34251 |
Miscellaneous databases
Pharosi | Q09028, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3137287 CHEMBL3301388 |
Genetic variation databases
BioMutai | RBBP4 |
DMDMi | 1172846 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000051186 | 2 – 425 | Histone-binding protein RBBP4Add BLAST | 424 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 4 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | ||
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 160 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 160 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 355 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q09028 |
jPOSTi | Q09028 |
MassIVEi | Q09028 |
MaxQBi | Q09028 |
PaxDbi | Q09028 |
PeptideAtlasi | Q09028 |
PRIDEi | Q09028 |
ProteomicsDBi | 58712 [Q09028-1] 58713 [Q09028-2] 58714 [Q09028-3] 58715 [Q09028-4] |
PTM databases
GlyGeni | Q09028, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q09028 |
PhosphoSitePlusi | Q09028 |
SwissPalmi | Q09028 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162521, Expressed in subventricular zone (outer) (primate) and 225 other tissues |
ExpressionAtlasi | Q09028, baseline and differential |
Genevisiblei | Q09028, HS |
Organism-specific databases
HPAi | ENSG00000162521, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SUV39H1 and HDAC7 (By similarity). Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (PubMed:8858152, PubMed:9427644). Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A (PubMed:8858152). Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7 (PubMed:9150135). The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex (PubMed:9150135, PubMed:9651585, PubMed:11118440, PubMed:11784859). The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex) (PubMed:9790534, PubMed:10444591, PubMed:11102443). The NuRD complex may also interact with MBD3L1 and MBD3L2 (PubMed:15456747, PubMed:15701600).
Interacts with MTA1 (PubMed:12920132).
Component of the PRC2 complex, which consists of the core subunits EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:12435631, PubMed:12351676, PubMed:29499137, PubMed:31959557).
Forms a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (PubMed:29499137).
Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19; PHF19 stabilizes the dimeric structure which enhances PRC2 interaction with chromatin (PubMed:31959557). Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7 (PubMed:14609955).
Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10734134).
Interacts with SPEN/MINT (PubMed:11331609).
Interacts with BRCA1 (PubMed:10220405).
Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP (PubMed:10866654).
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (PubMed:17671431, PubMed:17531812). The complex exists in quiescent cells where it represses cell cycle-dependent genes (PubMed:17671431, PubMed:17531812). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (PubMed:17671431, PubMed:17531812).
Interacts with PHF6 (PubMed:24554700).
Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity).
Interacts with ERCC6 (PubMed:26030138).
By similarity26 PublicationsBinary interactionsi
Hide detailsQ09028
GO - Molecular functioni
- histone binding Source: BHF-UCL
- histone deacetylase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111863, 296 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant CPX-569, Chromatin assembly factor 1 complex CPX-688, NuRF chromatin remodelling complex CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q09028 |
DIPi | DIP-33495N |
IntActi | Q09028, 167 interactors |
MINTi | Q09028 |
STRINGi | 9606.ENSP00000362592 |
Chemistry databases
BindingDBi | Q09028 |
Miscellaneous databases
RNActi | Q09028, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q09028 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q09028 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 122 – 155 | WD 1Add BLAST | 34 | |
Repeati | 175 – 206 | WD 2Add BLAST | 32 | |
Repeati | 225 – 256 | WD 3Add BLAST | 32 | |
Repeati | 271 – 302 | WD 4Add BLAST | 32 | |
Repeati | 315 – 346 | WD 5Add BLAST | 32 | |
Repeati | 372 – 403 | WD 6Add BLAST | 32 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0264, Eukaryota |
GeneTreei | ENSGT00940000153375 |
HOGENOMi | CLU_020445_3_1_1 |
InParanoidi | Q09028 |
OMAi | HLADFSW |
OrthoDBi | 831322at2759 |
PhylomeDBi | Q09028 |
TreeFami | TF106485 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
IDEALi | IID00317 |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR022052, Histone-bd_RBBP4_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12265, CAF1C_H4-bd, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL
60 70 80 90 100
PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS
110 120 130 140 150
EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL
160 170 180 190 200
VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH
210 220 230 240 250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ
260 270 280 290 300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
310 320 330 340 350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI
360 370 380 390 400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ
410 420
VWQMAENIYN DEDPEGSVDP EGQGS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YDK2 | H0YDK2_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 262 | Annotation score: | ||
H0YF10 | H0YF10_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 207 | Annotation score: | ||
H0YEU5 | H0YEU5_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 167 | Annotation score: | ||
H0YCT5 | H0YCT5_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 180 | Annotation score: | ||
C9JPP3 | C9JPP3_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 87 | Annotation score: | ||
E9PND5 | E9PND5_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 68 | Annotation score: | ||
E9PNS2 | E9PNS2_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 62 | Annotation score: | ||
E9PNS6 | E9PNS6_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 104 | Annotation score: | ||
E9PIC4 | E9PIC4_HUMAN | Histone-binding protein RBBP4 | RBBP4 | 87 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | F → G in AAH15123 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040087 | 1 – 35 | Missing in isoform 4. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_040088 | 7 | Missing in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_040089 | 405 – 425 | AENIY…EGQGS → ELVLDH in isoform 3. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74262 mRNA Translation: CAA52321.1 X71810 mRNA Translation: CAA50685.1 BT007309 mRNA Translation: AAP35973.1 AK299251 mRNA Translation: BAG61282.1 AK312571 mRNA Translation: BAG35466.1 AK222779 mRNA Translation: BAD96499.1 AC114489 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07513.1 CH471059 Genomic DNA Translation: EAX07514.1 BC003092 mRNA Translation: AAH03092.1 BC015123 mRNA Translation: AAH15123.1 BC053904 mRNA Translation: AAH53904.1 BC075836 mRNA Translation: AAH75836.1 |
CCDSi | CCDS366.1 [Q09028-1] CCDS44105.1 [Q09028-2] CCDS44106.1 [Q09028-4] |
PIRi | S36112 |
RefSeqi | NP_001128727.1, NM_001135255.1 [Q09028-2] NP_001128728.1, NM_001135256.1 [Q09028-4] NP_005601.1, NM_005610.2 [Q09028-1] |
Genome annotation databases
Ensembli | ENST00000373485; ENSP00000362584; ENSG00000162521 [Q09028-3] ENST00000373493; ENSP00000362592; ENSG00000162521 [Q09028-1] ENST00000414241; ENSP00000398242; ENSG00000162521 [Q09028-2] ENST00000458695; ENSP00000396057; ENSG00000162521 [Q09028-4] |
GeneIDi | 5928 |
KEGGi | hsa:5928 |
UCSCi | uc001bvr.3, human [Q09028-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74262 mRNA Translation: CAA52321.1 X71810 mRNA Translation: CAA50685.1 BT007309 mRNA Translation: AAP35973.1 AK299251 mRNA Translation: BAG61282.1 AK312571 mRNA Translation: BAG35466.1 AK222779 mRNA Translation: BAD96499.1 AC114489 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07513.1 CH471059 Genomic DNA Translation: EAX07514.1 BC003092 mRNA Translation: AAH03092.1 BC015123 mRNA Translation: AAH15123.1 BC053904 mRNA Translation: AAH53904.1 BC075836 mRNA Translation: AAH75836.1 |
CCDSi | CCDS366.1 [Q09028-1] CCDS44105.1 [Q09028-2] CCDS44106.1 [Q09028-4] |
PIRi | S36112 |
RefSeqi | NP_001128727.1, NM_001135255.1 [Q09028-2] NP_001128728.1, NM_001135256.1 [Q09028-4] NP_005601.1, NM_005610.2 [Q09028-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XU7 | X-ray | 1.90 | A/B | 1-425 | [»] | |
3GFC | X-ray | 2.30 | A | 1-425 | [»] | |
4PBY | X-ray | 2.50 | A/B | 1-425 | [»] | |
4PBZ | X-ray | 2.15 | A | 1-425 | [»] | |
4PC0 | X-ray | 2.50 | A/B | 1-425 | [»] | |
4R7A | X-ray | 1.85 | B | 1-425 | [»] | |
5FXY | X-ray | 3.20 | A/C/E/G | 1-425 | [»] | |
5VTB | X-ray | 2.40 | A | 1-425 | [»] | |
5WAI | X-ray | 2.90 | A/E | 1-425 | [»] | |
5WAK | X-ray | 3.20 | A | 1-425 | [»] | |
5XWR | X-ray | 2.69 | A/B | 1-425 | [»] | |
5XXQ | X-ray | 1.90 | A/B | 1-425 | [»] | |
5Y1U | X-ray | 2.14 | A/B | 1-425 | [»] | |
6BW3 | X-ray | 2.20 | A/C | 1-425 | [»] | |
6BW4 | X-ray | 2.00 | A/C | 1-425 | [»] | |
6C23 | electron microscopy | 3.90 | N | 1-425 | [»] | |
6C24 | electron microscopy | 3.50 | N | 1-425 | [»] | |
6G16 | X-ray | 2.80 | A/C/E/G | 1-425 | [»] | |
6NQ3 | X-ray | 2.89 | A/E | 1-425 | [»] | |
6ZRC | X-ray | 2.60 | A/B | 1-425 | [»] | |
6ZRD | X-ray | 2.50 | A/B | 1-425 | [»] | |
7AOA | electron microscopy | 19.40 | F/G | 1-425 | [»] | |
SMRi | Q09028 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111863, 296 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant CPX-569, Chromatin assembly factor 1 complex CPX-688, NuRF chromatin remodelling complex CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q09028 |
DIPi | DIP-33495N |
IntActi | Q09028, 167 interactors |
MINTi | Q09028 |
STRINGi | 9606.ENSP00000362592 |
Chemistry databases
BindingDBi | Q09028 |
ChEMBLi | CHEMBL3137287 CHEMBL3301388 |
PTM databases
GlyGeni | Q09028, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q09028 |
PhosphoSitePlusi | Q09028 |
SwissPalmi | Q09028 |
Genetic variation databases
BioMutai | RBBP4 |
DMDMi | 1172846 |
Proteomic databases
EPDi | Q09028 |
jPOSTi | Q09028 |
MassIVEi | Q09028 |
MaxQBi | Q09028 |
PaxDbi | Q09028 |
PeptideAtlasi | Q09028 |
PRIDEi | Q09028 |
ProteomicsDBi | 58712 [Q09028-1] 58713 [Q09028-2] 58714 [Q09028-3] 58715 [Q09028-4] |
Protocols and materials databases
Antibodypediai | 3343, 471 antibodies |
DNASUi | 5928 |
Genome annotation databases
Ensembli | ENST00000373485; ENSP00000362584; ENSG00000162521 [Q09028-3] ENST00000373493; ENSP00000362592; ENSG00000162521 [Q09028-1] ENST00000414241; ENSP00000398242; ENSG00000162521 [Q09028-2] ENST00000458695; ENSP00000396057; ENSG00000162521 [Q09028-4] |
GeneIDi | 5928 |
KEGGi | hsa:5928 |
UCSCi | uc001bvr.3, human [Q09028-1] |
Organism-specific databases
CTDi | 5928 |
DisGeNETi | 5928 |
GeneCardsi | RBBP4 |
HGNCi | HGNC:9887, RBBP4 |
HPAi | ENSG00000162521, Low tissue specificity |
MIMi | 602923, gene |
neXtProti | NX_Q09028 |
OpenTargetsi | ENSG00000162521 |
PharmGKBi | PA34251 |
VEuPathDBi | HostDB:ENSG00000162521.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0264, Eukaryota |
GeneTreei | ENSGT00940000153375 |
HOGENOMi | CLU_020445_3_1_1 |
InParanoidi | Q09028 |
OMAi | HLADFSW |
OrthoDBi | 831322at2759 |
PhylomeDBi | Q09028 |
TreeFami | TF106485 |
Enzyme and pathway databases
PathwayCommonsi | Q09028 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133, G0 and Early G1 R-HSA-156711, Polo-like kinase mediated events R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214841, PKMTs methylate histone lysines R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-8953750, Transcriptional Regulation by E2F6 R-HSA-9609690, HCMV Early Events R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q09028 |
SIGNORi | Q09028 |
Miscellaneous databases
BioGRID-ORCSi | 5928, 733 hits in 1013 CRISPR screens |
ChiTaRSi | RBBP4, human |
EvolutionaryTracei | Q09028 |
GeneWikii | RBBP4 |
GenomeRNAii | 5928 |
Pharosi | Q09028, Tbio |
PROi | PR:Q09028 |
RNActi | Q09028, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162521, Expressed in subventricular zone (outer) (primate) and 225 other tissues |
ExpressionAtlasi | Q09028, baseline and differential |
Genevisiblei | Q09028, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
IDEALi | IID00317 |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR022052, Histone-bd_RBBP4_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12265, CAF1C_H4-bd, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBBP4_HUMAN | |
Accessioni | Q09028Primary (citable) accession number: Q09028 Secondary accession number(s): B2R6G9 Q96BV9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 225 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families