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Protein

Myotonin-protein kinase

Gene

DMPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.6 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Activity regulationi

Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G-protein second messengers.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100ATP1
Active sitei195Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 85ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-5578775 Ion homeostasis
SignaLinkiQ09013
SIGNORiQ09013

Names & Taxonomyi

Protein namesi
Recommended name:
Myotonin-protein kinase (EC:2.7.11.1)
Short name:
MT-PK
Alternative name(s):
DM-kinase
Short name:
DMK
DM1 protein kinase
DMPK
Myotonic dystrophy protein kinase
Gene namesi
Name:DMPK
Synonyms:DM1PK, MDPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104936.17
HGNCiHGNC:2933 DMPK
MIMi605377 gene
neXtProtiNX_Q09013

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 590CytoplasmicSequence analysisAdd BLAST590
Transmembranei591 – 611Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini612 – 629LumenalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Dystrophia myotonica 1 (DM1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.2 Publications
Disease descriptionA muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias.
See also OMIM:160900

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi100K → A: Loss of kinase activity. 1 Publication1

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNETi1760
GeneReviewsiDMPK
MalaCardsiDMPK
MIMi160900 phenotype
OpenTargetsiENSG00000104936
Orphaneti273 Steinert myotonic dystrophy
PharmGKBiPA27380

Chemistry databases

ChEMBLiCHEMBL5320
GuidetoPHARMACOLOGYi1505

Polymorphism and mutation databases

BioMutaiDMPK
DMDMi363548519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859241 – 629Myotonin-protein kinaseAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216Phosphoserine; by autocatalysisBy similarity1
Modified residuei228Phosphoserine; by autocatalysisBy similarity1
Modified residuei234Phosphothreonine; by autocatalysisBy similarity1

Post-translational modificationi

Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK.1 Publication
Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ09013
PeptideAtlasiQ09013
PRIDEiQ09013
ProteomicsDBi58699
58700 [Q09013-1]
58701 [Q09013-10]
58702 [Q09013-11]
58703 [Q09013-12]
58704 [Q09013-15]
58705 [Q09013-16]
58706 [Q09013-2]
58707 [Q09013-5]
58708 [Q09013-6]
58709 [Q09013-7]
58710 [Q09013-8]
TopDownProteomicsiQ09013-11 [Q09013-11]

2D gel databases

REPRODUCTION-2DPAGEiQ09013

PTM databases

iPTMnetiQ09013
PhosphoSitePlusiQ09013

Expressioni

Tissue specificityi

Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.1 Publication

Gene expression databases

BgeeiENSG00000104936 Expressed in 193 organ(s), highest expression level in heart left ventricle
CleanExiHS_DMPK
ExpressionAtlasiQ09013 baseline and differential
GenevisibleiQ09013 HS

Organism-specific databases

HPAiHPA007164
HPA008905

Interactioni

Subunit structurei

Homodimer; homodimerization stimulates the kinase activity. Interacts with HSPB2; may enhance DMPK kinase activity. Interacts with PLN; phosphorylates PLN. May interact with RAC1; may regulate DMPK kinase activity. Interacts with LMNA; may regulate nuclear envelope stability.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PLNP266784EBI-692774,EBI-692836

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108100, 15 interactors
IntActiQ09013, 15 interactors
MINTiQ09013
STRINGi9606.ENSP00000345997

Chemistry databases

BindingDBiQ09013

Structurei

Secondary structure

1629
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ09013
SMRiQ09013
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09013

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 339Protein kinasePROSITE-ProRule annotationAdd BLAST269
Domaini340 – 415AGC-kinase C-terminalAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili457 – 5362 PublicationsAdd BLAST80

Domaini

The coiled coil domain is required for homodimerization and regulates the enzymatic activity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT50 Eukaryota
ENOG410YFQZ LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000233033
HOVERGENiHBG107817
InParanoidiQ09013
KOiK08788
OMAiFLQWVEP
OrthoDBiEOG091G09EX
TreeFamiTF105337

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR014930 Myotonic_dystrophy_kinase_coil
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF08826 DMPK_coil, 1 hit
PF00069 Pkinase, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011252 Myotonic_dystrophy_kinase_coil, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (12+)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q09013-9) [UniParc]FASTAAdd to basket
Also known as: DMPK A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF
60 70 80 90 100
LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK
110 120 130 140 150
IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY
160 170 180 190 200
YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN
210 220 230 240 250
ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP
260 270 280 290 300
GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP
310 320 330 340 350
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS
360 370 380 390 400
VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF
410 420 430 440 450
VGYSYSCMAL RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE
460 470 480 490 500
VAVPAAVPAA EAEAEVTLRE LQEALEEEVL TRQSLSREME AIRTDNQNFA
510 520 530 540 550
SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS PRATDPPSHL
560 570 580 590 600
DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR
610 620
AAALGCIGLV AHAGQLTAVW RRPGAARAP
Length:629
Mass (Da):69,385
Last modified:December 14, 2011 - v3
Checksum:i46783ED4AE65B493
GO
Isoform 2 (identifier: Q09013-11) [UniParc]FASTAAdd to basket
Also known as: DMPK B

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.

Show »
Length:624
Mass (Da):69,028
Checksum:i7ECA31ED9A84E7E1
GO
Isoform 3 (identifier: Q09013-16) [UniParc]FASTAAdd to basket
Also known as: DMPK C

The sequence of this isoform differs from the canonical sequence as follows:
     550-629: LDGPPAVAVG...WRRPGAARAP → MAPRPWLWAS...AQEPPALPEP

Note: No experimental confirmation available.
Show »
Length:630
Mass (Da):69,950
Checksum:i52B2B388CD99AA2F
GO
Isoform 4 (identifier: Q09013-15) [UniParc]FASTAAdd to basket
Also known as: DMPK D

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     550-629: LDGPPAVAVG...WRRPGAARAP → MAPRPWLWAS...AQEPPALPEP

Show »
Length:625
Mass (Da):69,592
Checksum:i10EA0187F4AD4B7C
GO
Isoform 5 (identifier: Q09013-10) [UniParc]FASTAAdd to basket
Also known as: DMPK E

The sequence of this isoform differs from the canonical sequence as follows:
     534-535: AV → GP
     536-629: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):59,804
Checksum:i9A08CEA02FAE8828
GO
Isoform 6 (identifier: Q09013-12) [UniParc]FASTAAdd to basket
Also known as: DMPK F

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     534-535: AV → GP
     536-629: Missing.

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):59,446
Checksum:i5E41498FDA6C22D4
GO
Isoform 7 (identifier: Q09013-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP

Show »
Length:639
Mass (Da):70,371
Checksum:i69A831604F7F8D38
GO
Isoform 8 (identifier: Q09013-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:540
Mass (Da):59,334
Checksum:iA7BB715CB845055C
GO
Isoform 9 (identifier: Q09013-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     226-275: Missing.

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):65,076
Checksum:i2558F658CFA1FCE1
GO
Isoform 10 (identifier: Q09013-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     378-382: Missing.

Note: No experimental confirmation available.
Show »
Length:634
Mass (Da):70,014
Checksum:i94F39ADE9A8F4AFC
GO
Isoform 11 (identifier: Q09013-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     550-579: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):67,263
Checksum:i58A97059F9590719
GO
Isoform 12 (identifier: Q09013-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     534-535: AV → GP
     536-629: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):60,790
Checksum:iEF016FDBE3933553
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R333M0R333_HUMAN
Myotonin-protein kinase
DMPK
635Annotation score:
M0R1F3M0R1F3_HUMAN
Myotonin-protein kinase
DMPK
188Annotation score:
M0QZ00M0QZ00_HUMAN
Myotonin-protein kinase
DMPK
125Annotation score:
M0QXJ9M0QXJ9_HUMAN
Myotonin-protein kinase
DMPK
183Annotation score:
K7EQX1K7EQX1_HUMAN
Myotonin-protein kinase
DMPK
78Annotation score:

Sequence cautioni

The sequence AAA64884 differs from that shown. Reason: Frameshift at positions 56, 555 and 568.Curated
The sequence AAA87583 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti474A → P in AAB31800 (PubMed:8076686).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058334423L → V4 PublicationsCorresponds to variant dbSNP:rs527221EnsemblClinVar.1
Natural variantiVAR_040452428L → V in a lung small cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0420981 – 89Missing in isoform 8. CuratedAdd BLAST89
Alternative sequenceiVSP_0420991 – 53MSAEV…DFLQW → MGGHFWPPEPYTVFMWGSPW EADSPRVKLRGREKGRQTEG GAFPLVSSALSGDPRFFSPT TPP in isoform 7, isoform 9, isoform 10, isoform 11 and isoform 12. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_042100226 – 275Missing in isoform 9. CuratedAdd BLAST50
Alternative sequenceiVSP_042101378 – 382Missing in isoform 2, isoform 4, isoform 6 and isoform 10. 3 Publications5
Alternative sequenceiVSP_042102534 – 535AV → GP in isoform 5, isoform 6 and isoform 12. Curated2
Alternative sequenceiVSP_042103536 – 629Missing in isoform 5, isoform 6 and isoform 12. CuratedAdd BLAST94
Alternative sequenceiVSP_042104550 – 629LDGPP…AARAP → MAPRPWLWASARWWGQAPCT AATCCSLPGSLGLAYRRRFP CSCSPLFCLVPPPWAALGWW PTPANSPQSGAAQEPPALPE P in isoform 3 and isoform 4. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_042105550 – 579Missing in isoform 11. CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87312 mRNA No translation available.
L19268 mRNA Translation: AAA36206.1
L19266 Genomic DNA Translation: AAA36205.1
L08835 Genomic DNA Translation: AAC14449.1
L08835 Genomic DNA Translation: AAC14451.1
L08835 Genomic DNA Translation: AAC14448.1
L08835 Genomic DNA Translation: AAC14450.1
L00727 Genomic DNA Translation: AAA75235.1
L00727 Genomic DNA Translation: AAA75236.1
L00727 Genomic DNA Translation: AAA75237.1
L00727 Genomic DNA Translation: AAA75238.1
L00727 Genomic DNA Translation: AAA75239.1
L00727 Genomic DNA Translation: AAA75240.1
S72883 mRNA Translation: AAB31800.1
HQ205626 Genomic DNA Translation: ADP91337.1
HQ205627 Genomic DNA Translation: ADP91341.1
HQ205628 Genomic DNA Translation: ADP91345.1
HQ205629 Genomic DNA Translation: ADP91349.1
HQ205630 Genomic DNA Translation: ADP91353.1
HQ205631 Genomic DNA Translation: ADP91357.1
HQ205632 Genomic DNA Translation: ADP91361.1
HQ205633 Genomic DNA Translation: ADP91365.1
HQ205634 Genomic DNA Translation: ADP91369.1
HQ205635 Genomic DNA Translation: ADP91373.1
HQ205636 Genomic DNA Translation: ADP91377.1
HQ205637 Genomic DNA Translation: ADP91381.1
HQ205638 Genomic DNA Translation: ADP91385.1
HQ205639 Genomic DNA Translation: ADP91389.1
HQ205640 Genomic DNA Translation: ADP91393.1
HQ205641 Genomic DNA Translation: ADP91397.1
HQ205642 Genomic DNA Translation: ADP91401.1
HQ205643 Genomic DNA Translation: ADP91405.1
HQ205644 Genomic DNA Translation: ADP91409.1
HQ205645 Genomic DNA Translation: ADP91413.1
HQ205646 Genomic DNA Translation: ADP91417.1
HQ205647 Genomic DNA Translation: ADP91421.1
HQ205648 Genomic DNA Translation: ADP91425.1
HQ205649 Genomic DNA Translation: ADP91429.1
HQ205650 Genomic DNA Translation: ADP91433.1
HQ205651 Genomic DNA Translation: ADP91437.1
HQ205652 Genomic DNA Translation: ADP91441.1
HQ205653 Genomic DNA Translation: ADP91445.1
HQ205654 Genomic DNA Translation: ADP91449.1
HQ205655 Genomic DNA Translation: ADP91453.1
HQ205656 Genomic DNA Translation: ADP91457.1
HQ205657 Genomic DNA Translation: ADP91461.1
HQ205658 Genomic DNA Translation: ADP91465.1
HQ205659 Genomic DNA Translation: ADP91469.1
HQ205660 Genomic DNA Translation: ADP91473.1
HQ205661 Genomic DNA Translation: ADP91477.1
HQ205662 Genomic DNA Translation: ADP91481.1
HQ205663 Genomic DNA Translation: ADP91485.1
HQ205664 Genomic DNA Translation: ADP91489.1
HQ205665 Genomic DNA Translation: ADP91493.1
KJ534827 mRNA Translation: AHW56467.1
CH471126 Genomic DNA Translation: EAW57380.1
CH471126 Genomic DNA Translation: EAW57382.1
BC062553 mRNA Translation: AAH62553.1
M94203 mRNA Translation: AAA64884.1 Frameshift.
U46546 mRNA Translation: AAA87583.1 Sequence problems.
CCDSiCCDS12674.1 [Q09013-9]
CCDS46117.1 [Q09013-15]
CCDS46118.1 [Q09013-11]
CCDS46119.1 [Q09013-1]
CCDS74400.1 [Q09013-12]
PIRiB49364
RefSeqiNP_001075029.1, NM_001081560.2 [Q09013-11]
NP_001075031.1, NM_001081562.2 [Q09013-15]
NP_001075032.1, NM_001081563.2 [Q09013-1]
NP_001275694.1, NM_001288765.1
NP_004400.4, NM_004409.4 [Q09013-9]
UniGeneiHs.631596

Genome annotation databases

EnsembliENST00000291270; ENSP00000291270; ENSG00000104936 [Q09013-9]
ENST00000343373; ENSP00000345997; ENSG00000104936 [Q09013-1]
ENST00000354227; ENSP00000346168; ENSG00000104936 [Q09013-12]
ENST00000447742; ENSP00000413417; ENSG00000104936 [Q09013-11]
ENST00000458663; ENSP00000401753; ENSG00000104936 [Q09013-15]
ENST00000618091; ENSP00000482746; ENSG00000104936 [Q09013-15]
GeneIDi1760
KEGGihsa:1760
UCSCiuc002pdd.3 human [Q09013-9]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDMPK_HUMAN
AccessioniPrimary (citable) accession number: Q09013
Secondary accession number(s): E5KR08, Q16205, Q6P5Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 14, 2011
Last modified: September 12, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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