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Protein

Myotonin-protein kinase

Gene

DMPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G-protein second messengers.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei100ATP1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei195Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi77 – 85ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5578775 Ion homeostasis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q09013

SIGNOR Signaling Network Open Resource

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SIGNORi
Q09013

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotonin-protein kinase (EC:2.7.11.1)
Short name:
MT-PK
Alternative name(s):
DM-kinase
Short name:
DMK
DM1 protein kinase
DMPK
Myotonic dystrophy protein kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMPK
Synonyms:DM1PK, MDPK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000104936.17

Human Gene Nomenclature Database

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HGNCi
HGNC:2933 DMPK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605377 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q09013

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 590CytoplasmicSequence analysisAdd BLAST590
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei591 – 611Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini612 – 629LumenalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystrophia myotonica 1 (DM1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.2 Publications
Disease descriptionA muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias.
See also OMIM:160900

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100K → A: Loss of kinase activity. 1 Publication1

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...
DisGeNETi
1760

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DMPK

MalaCards human disease database

More...
MalaCardsi
DMPK
MIMi160900 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000104936

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
273 Steinert myotonic dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27380

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5320

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1505

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DMPK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
363548519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859241 – 629Myotonin-protein kinaseAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei216Phosphoserine; by autocatalysisBy similarity1
Modified residuei228Phosphoserine; by autocatalysisBy similarity1
Modified residuei234Phosphothreonine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK.1 Publication
Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q09013

PeptideAtlas

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PeptideAtlasi
Q09013

PRoteomics IDEntifications database

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PRIDEi
Q09013

ProteomicsDB human proteome resource

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ProteomicsDBi
58699
58700 [Q09013-1]
58701 [Q09013-10]
58702 [Q09013-11]
58703 [Q09013-12]
58704 [Q09013-15]
58705 [Q09013-16]
58706 [Q09013-2]
58707 [Q09013-5]
58708 [Q09013-6]
58709 [Q09013-7]
58710 [Q09013-8]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q09013-11 [Q09013-11]

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
Q09013

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q09013

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q09013

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000104936 Expressed in 193 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

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CleanExi
HS_DMPK

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q09013 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q09013 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007164
HPA008905

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerization stimulates the kinase activity. Interacts with HSPB2; may enhance DMPK kinase activity. Interacts with PLN; phosphorylates PLN. May interact with RAC1; may regulate DMPK kinase activity. Interacts with LMNA; may regulate nuclear envelope stability.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PLNP266784EBI-692774,EBI-692836

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108100, 15 interactors

Protein interaction database and analysis system

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IntActi
Q09013, 15 interactors

Molecular INTeraction database

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MINTi
Q09013

STRING: functional protein association networks

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STRINGi
9606.ENSP00000345997

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q09013

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1629
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q09013

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q09013

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q09013

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 339Protein kinasePROSITE-ProRule annotationAdd BLAST269
Domaini340 – 415AGC-kinase C-terminalAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili457 – 5362 PublicationsAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil domain is required for homodimerization and regulates the enzymatic activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IT50 Eukaryota
ENOG410YFQZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233033

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107817

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q09013

KEGG Orthology (KO)

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KOi
K08788

Identification of Orthologs from Complete Genome Data

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OMAi
ITELHYA

Database of Orthologous Groups

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OrthoDBi
EOG091G09EX

TreeFam database of animal gene trees

More...
TreeFami
TF105337

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR014930 Myotonic_dystrophy_kinase_coil
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08826 DMPK_coil, 1 hit
PF00069 Pkinase, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD011252 Myotonic_dystrophy_kinase_coil, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q09013-9) [UniParc]FASTAAdd to basket
Also known as: DMPK A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF
60 70 80 90 100
LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK
110 120 130 140 150
IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY
160 170 180 190 200
YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN
210 220 230 240 250
ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP
260 270 280 290 300
GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP
310 320 330 340 350
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS
360 370 380 390 400
VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF
410 420 430 440 450
VGYSYSCMAL RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE
460 470 480 490 500
VAVPAAVPAA EAEAEVTLRE LQEALEEEVL TRQSLSREME AIRTDNQNFA
510 520 530 540 550
SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS PRATDPPSHL
560 570 580 590 600
DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR
610 620
AAALGCIGLV AHAGQLTAVW RRPGAARAP
Length:629
Mass (Da):69,385
Last modified:December 14, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46783ED4AE65B493
GO
Isoform 2 (identifier: Q09013-11) [UniParc]FASTAAdd to basket
Also known as: DMPK B

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.

Show »
Length:624
Mass (Da):69,028
Checksum:i7ECA31ED9A84E7E1
GO
Isoform 3 (identifier: Q09013-16) [UniParc]FASTAAdd to basket
Also known as: DMPK C

The sequence of this isoform differs from the canonical sequence as follows:
     550-629: LDGPPAVAVG...WRRPGAARAP → MAPRPWLWAS...AQEPPALPEP

Note: No experimental confirmation available.
Show »
Length:630
Mass (Da):69,950
Checksum:i52B2B388CD99AA2F
GO
Isoform 4 (identifier: Q09013-15) [UniParc]FASTAAdd to basket
Also known as: DMPK D

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     550-629: LDGPPAVAVG...WRRPGAARAP → MAPRPWLWAS...AQEPPALPEP

Show »
Length:625
Mass (Da):69,592
Checksum:i10EA0187F4AD4B7C
GO
Isoform 5 (identifier: Q09013-10) [UniParc]FASTAAdd to basket
Also known as: DMPK E

The sequence of this isoform differs from the canonical sequence as follows:
     534-535: AV → GP
     536-629: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):59,804
Checksum:i9A08CEA02FAE8828
GO
Isoform 6 (identifier: Q09013-12) [UniParc]FASTAAdd to basket
Also known as: DMPK F

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     534-535: AV → GP
     536-629: Missing.

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):59,446
Checksum:i5E41498FDA6C22D4
GO
Isoform 7 (identifier: Q09013-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP

Show »
Length:639
Mass (Da):70,371
Checksum:i69A831604F7F8D38
GO
Isoform 8 (identifier: Q09013-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:540
Mass (Da):59,334
Checksum:iA7BB715CB845055C
GO
Isoform 9 (identifier: Q09013-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     226-275: Missing.

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):65,076
Checksum:i2558F658CFA1FCE1
GO
Isoform 10 (identifier: Q09013-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     378-382: Missing.

Note: No experimental confirmation available.
Show »
Length:634
Mass (Da):70,014
Checksum:i94F39ADE9A8F4AFC
GO
Isoform 11 (identifier: Q09013-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     550-579: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):67,263
Checksum:i58A97059F9590719
GO
Isoform 12 (identifier: Q09013-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAEVRLRRL...DKYVADFLQW → MGGHFWPPEP...PRFFSPTTPP
     534-535: AV → GP
     536-629: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):60,790
Checksum:iEF016FDBE3933553
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R333M0R333_HUMAN
Myotonin-protein kinase
DMPK
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1F3M0R1F3_HUMAN
Myotonin-protein kinase
DMPK
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ00M0QZ00_HUMAN
Myotonin-protein kinase
DMPK
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXJ9M0QXJ9_HUMAN
Myotonin-protein kinase
DMPK
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQX1K7EQX1_HUMAN
Myotonin-protein kinase
DMPK
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA64884 differs from that shown. Reason: Frameshift at positions 56, 555 and 568.Curated
The sequence AAA87583 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti474A → P in AAB31800 (PubMed:8076686).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058334423L → V4 PublicationsCorresponds to variant dbSNP:rs527221EnsemblClinVar.1
Natural variantiVAR_040452428L → V in a lung small cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0420981 – 89Missing in isoform 8. CuratedAdd BLAST89
Alternative sequenceiVSP_0420991 – 53MSAEV…DFLQW → MGGHFWPPEPYTVFMWGSPW EADSPRVKLRGREKGRQTEG GAFPLVSSALSGDPRFFSPT TPP in isoform 7, isoform 9, isoform 10, isoform 11 and isoform 12. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_042100226 – 275Missing in isoform 9. CuratedAdd BLAST50
Alternative sequenceiVSP_042101378 – 382Missing in isoform 2, isoform 4, isoform 6 and isoform 10. 3 Publications5
Alternative sequenceiVSP_042102534 – 535AV → GP in isoform 5, isoform 6 and isoform 12. Curated2
Alternative sequenceiVSP_042103536 – 629Missing in isoform 5, isoform 6 and isoform 12. CuratedAdd BLAST94
Alternative sequenceiVSP_042104550 – 629LDGPP…AARAP → MAPRPWLWASARWWGQAPCT AATCCSLPGSLGLAYRRRFP CSCSPLFCLVPPPWAALGWW PTPANSPQSGAAQEPPALPE P in isoform 3 and isoform 4. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_042105550 – 579Missing in isoform 11. CuratedAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M87312 mRNA No translation available.
L19268 mRNA Translation: AAA36206.1
L19266 Genomic DNA Translation: AAA36205.1
L08835 Genomic DNA Translation: AAC14449.1
L08835 Genomic DNA Translation: AAC14451.1
L08835 Genomic DNA Translation: AAC14448.1
L08835 Genomic DNA Translation: AAC14450.1
L00727 Genomic DNA Translation: AAA75235.1
L00727 Genomic DNA Translation: AAA75236.1
L00727 Genomic DNA Translation: AAA75237.1
L00727 Genomic DNA Translation: AAA75238.1
L00727 Genomic DNA Translation: AAA75239.1
L00727 Genomic DNA Translation: AAA75240.1
S72883 mRNA Translation: AAB31800.1
HQ205626 Genomic DNA Translation: ADP91337.1
HQ205627 Genomic DNA Translation: ADP91341.1
HQ205628 Genomic DNA Translation: ADP91345.1
HQ205629 Genomic DNA Translation: ADP91349.1
HQ205630 Genomic DNA Translation: ADP91353.1
HQ205631 Genomic DNA Translation: ADP91357.1
HQ205632 Genomic DNA Translation: ADP91361.1
HQ205633 Genomic DNA Translation: ADP91365.1
HQ205634 Genomic DNA Translation: ADP91369.1
HQ205635 Genomic DNA Translation: ADP91373.1
HQ205636 Genomic DNA Translation: ADP91377.1
HQ205637 Genomic DNA Translation: ADP91381.1
HQ205638 Genomic DNA Translation: ADP91385.1
HQ205639 Genomic DNA Translation: ADP91389.1
HQ205640 Genomic DNA Translation: ADP91393.1
HQ205641 Genomic DNA Translation: ADP91397.1
HQ205642 Genomic DNA Translation: ADP91401.1
HQ205643 Genomic DNA Translation: ADP91405.1
HQ205644 Genomic DNA Translation: ADP91409.1
HQ205645 Genomic DNA Translation: ADP91413.1
HQ205646 Genomic DNA Translation: ADP91417.1
HQ205647 Genomic DNA Translation: ADP91421.1
HQ205648 Genomic DNA Translation: ADP91425.1
HQ205649 Genomic DNA Translation: ADP91429.1
HQ205650 Genomic DNA Translation: ADP91433.1
HQ205651 Genomic DNA Translation: ADP91437.1
HQ205652 Genomic DNA Translation: ADP91441.1
HQ205653 Genomic DNA Translation: ADP91445.1
HQ205654 Genomic DNA Translation: ADP91449.1
HQ205655 Genomic DNA Translation: ADP91453.1
HQ205656 Genomic DNA Translation: ADP91457.1
HQ205657 Genomic DNA Translation: ADP91461.1
HQ205658 Genomic DNA Translation: ADP91465.1
HQ205659 Genomic DNA Translation: ADP91469.1
HQ205660 Genomic DNA Translation: ADP91473.1
HQ205661 Genomic DNA Translation: ADP91477.1
HQ205662 Genomic DNA Translation: ADP91481.1
HQ205663 Genomic DNA Translation: ADP91485.1
HQ205664 Genomic DNA Translation: ADP91489.1
HQ205665 Genomic DNA Translation: ADP91493.1
KJ534827 mRNA Translation: AHW56467.1
CH471126 Genomic DNA Translation: EAW57380.1
CH471126 Genomic DNA Translation: EAW57382.1
BC062553 mRNA Translation: AAH62553.1
M94203 mRNA Translation: AAA64884.1 Frameshift.
U46546 mRNA Translation: AAA87583.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12674.1 [Q09013-9]
CCDS46117.1 [Q09013-15]
CCDS46118.1 [Q09013-11]
CCDS46119.1 [Q09013-1]
CCDS74400.1 [Q09013-12]

Protein sequence database of the Protein Information Resource

More...
PIRi
B49364

NCBI Reference Sequences

More...
RefSeqi
NP_001075029.1, NM_001081560.2 [Q09013-11]
NP_001075031.1, NM_001081562.2 [Q09013-15]
NP_001075032.1, NM_001081563.2 [Q09013-1]
NP_001275694.1, NM_001288765.1
NP_004400.4, NM_004409.4 [Q09013-9]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.631596

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291270; ENSP00000291270; ENSG00000104936 [Q09013-9]
ENST00000343373; ENSP00000345997; ENSG00000104936 [Q09013-1]
ENST00000354227; ENSP00000346168; ENSG00000104936 [Q09013-12]
ENST00000447742; ENSP00000413417; ENSG00000104936 [Q09013-11]
ENST00000458663; ENSP00000401753; ENSG00000104936 [Q09013-15]
ENST00000618091; ENSP00000482746; ENSG00000104936 [Q09013-15]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1760

UCSC genome browser

More...
UCSCi
uc002pdd.3 human [Q09013-9]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87312 mRNA No translation available.
L19268 mRNA Translation: AAA36206.1
L19266 Genomic DNA Translation: AAA36205.1
L08835 Genomic DNA Translation: AAC14449.1
L08835 Genomic DNA Translation: AAC14451.1
L08835 Genomic DNA Translation: AAC14448.1
L08835 Genomic DNA Translation: AAC14450.1
L00727 Genomic DNA Translation: AAA75235.1
L00727 Genomic DNA Translation: AAA75236.1
L00727 Genomic DNA Translation: AAA75237.1
L00727 Genomic DNA Translation: AAA75238.1
L00727 Genomic DNA Translation: AAA75239.1
L00727 Genomic DNA Translation: AAA75240.1
S72883 mRNA Translation: AAB31800.1
HQ205626 Genomic DNA Translation: ADP91337.1
HQ205627 Genomic DNA Translation: ADP91341.1
HQ205628 Genomic DNA Translation: ADP91345.1
HQ205629 Genomic DNA Translation: ADP91349.1
HQ205630 Genomic DNA Translation: ADP91353.1
HQ205631 Genomic DNA Translation: ADP91357.1
HQ205632 Genomic DNA Translation: ADP91361.1
HQ205633 Genomic DNA Translation: ADP91365.1
HQ205634 Genomic DNA Translation: ADP91369.1
HQ205635 Genomic DNA Translation: ADP91373.1
HQ205636 Genomic DNA Translation: ADP91377.1
HQ205637 Genomic DNA Translation: ADP91381.1
HQ205638 Genomic DNA Translation: ADP91385.1
HQ205639 Genomic DNA Translation: ADP91389.1
HQ205640 Genomic DNA Translation: ADP91393.1
HQ205641 Genomic DNA Translation: ADP91397.1
HQ205642 Genomic DNA Translation: ADP91401.1
HQ205643 Genomic DNA Translation: ADP91405.1
HQ205644 Genomic DNA Translation: ADP91409.1
HQ205645 Genomic DNA Translation: ADP91413.1
HQ205646 Genomic DNA Translation: ADP91417.1
HQ205647 Genomic DNA Translation: ADP91421.1
HQ205648 Genomic DNA Translation: ADP91425.1
HQ205649 Genomic DNA Translation: ADP91429.1
HQ205650 Genomic DNA Translation: ADP91433.1
HQ205651 Genomic DNA Translation: ADP91437.1
HQ205652 Genomic DNA Translation: ADP91441.1
HQ205653 Genomic DNA Translation: ADP91445.1
HQ205654 Genomic DNA Translation: ADP91449.1
HQ205655 Genomic DNA Translation: ADP91453.1
HQ205656 Genomic DNA Translation: ADP91457.1
HQ205657 Genomic DNA Translation: ADP91461.1
HQ205658 Genomic DNA Translation: ADP91465.1
HQ205659 Genomic DNA Translation: ADP91469.1
HQ205660 Genomic DNA Translation: ADP91473.1
HQ205661 Genomic DNA Translation: ADP91477.1
HQ205662 Genomic DNA Translation: ADP91481.1
HQ205663 Genomic DNA Translation: ADP91485.1
HQ205664 Genomic DNA Translation: ADP91489.1
HQ205665 Genomic DNA Translation: ADP91493.1
KJ534827 mRNA Translation: AHW56467.1
CH471126 Genomic DNA Translation: EAW57380.1
CH471126 Genomic DNA Translation: EAW57382.1
BC062553 mRNA Translation: AAH62553.1
M94203 mRNA Translation: AAA64884.1 Frameshift.
U46546 mRNA Translation: AAA87583.1 Sequence problems.
CCDSiCCDS12674.1 [Q09013-9]
CCDS46117.1 [Q09013-15]
CCDS46118.1 [Q09013-11]
CCDS46119.1 [Q09013-1]
CCDS74400.1 [Q09013-12]
PIRiB49364
RefSeqiNP_001075029.1, NM_001081560.2 [Q09013-11]
NP_001075031.1, NM_001081562.2 [Q09013-15]
NP_001075032.1, NM_001081563.2 [Q09013-1]
NP_001275694.1, NM_001288765.1
NP_004400.4, NM_004409.4 [Q09013-9]
UniGeneiHs.631596

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WT6X-ray1.60A/B/D460-537[»]
2VD5X-ray2.80A/B11-420[»]
ProteinModelPortaliQ09013
SMRiQ09013
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108100, 15 interactors
IntActiQ09013, 15 interactors
MINTiQ09013
STRINGi9606.ENSP00000345997

Chemistry databases

BindingDBiQ09013
ChEMBLiCHEMBL5320
GuidetoPHARMACOLOGYi1505

PTM databases

iPTMnetiQ09013
PhosphoSitePlusiQ09013

Polymorphism and mutation databases

BioMutaiDMPK
DMDMi363548519

2D gel databases

REPRODUCTION-2DPAGEiQ09013

Proteomic databases

PaxDbiQ09013
PeptideAtlasiQ09013
PRIDEiQ09013
ProteomicsDBi58699
58700 [Q09013-1]
58701 [Q09013-10]
58702 [Q09013-11]
58703 [Q09013-12]
58704 [Q09013-15]
58705 [Q09013-16]
58706 [Q09013-2]
58707 [Q09013-5]
58708 [Q09013-6]
58709 [Q09013-7]
58710 [Q09013-8]
TopDownProteomicsiQ09013-11 [Q09013-11]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291270; ENSP00000291270; ENSG00000104936 [Q09013-9]
ENST00000343373; ENSP00000345997; ENSG00000104936 [Q09013-1]
ENST00000354227; ENSP00000346168; ENSG00000104936 [Q09013-12]
ENST00000447742; ENSP00000413417; ENSG00000104936 [Q09013-11]
ENST00000458663; ENSP00000401753; ENSG00000104936 [Q09013-15]
ENST00000618091; ENSP00000482746; ENSG00000104936 [Q09013-15]
GeneIDi1760
KEGGihsa:1760
UCSCiuc002pdd.3 human [Q09013-9]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1760
DisGeNETi1760
EuPathDBiHostDB:ENSG00000104936.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DMPK
GeneReviewsiDMPK

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0137522
HGNCiHGNC:2933 DMPK
HPAiHPA007164
HPA008905
MalaCardsiDMPK
MIMi160900 phenotype
605377 gene
neXtProtiNX_Q09013
OpenTargetsiENSG00000104936
Orphaneti273 Steinert myotonic dystrophy
PharmGKBiPA27380

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IT50 Eukaryota
ENOG410YFQZ LUCA
GeneTreeiENSGT00940000162019
HOGENOMiHOG000233033
HOVERGENiHBG107817
InParanoidiQ09013
KOiK08788
OMAiITELHYA
OrthoDBiEOG091G09EX
TreeFamiTF105337

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-5578775 Ion homeostasis
SignaLinkiQ09013
SIGNORiQ09013

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DMPK human
EvolutionaryTraceiQ09013

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Myotonin-protein_kinase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1760

Protein Ontology

More...
PROi
PR:Q09013

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104936 Expressed in 193 organ(s), highest expression level in heart left ventricle
CleanExiHS_DMPK
ExpressionAtlasiQ09013 baseline and differential
GenevisibleiQ09013 HS

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR014930 Myotonic_dystrophy_kinase_coil
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF08826 DMPK_coil, 1 hit
PF00069 Pkinase, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011252 Myotonic_dystrophy_kinase_coil, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMPK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q09013
Secondary accession number(s): E5KR08, Q16205, Q6P5Z6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 14, 2011
Last modified: December 5, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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