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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila madeirensis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila madeirensis (Fruit fly)
Taxonomic identifieri30013 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012466 Dmad\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544732 – 254Alcohol dehydrogenaseAdd BLAST253

Proteomic databases

PRIDEiQ09010

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ09010
SMRiQ09010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09010-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTNKNVVF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTVPVAE TTKLLKTIFA QIKTIDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNYTG LVNTTTAILD FWDKRKGGPG GIICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWKLDLGT LESITWTKHW

DSGI
Length:254
Mass (Da):27,608
Last modified:January 23, 2007 - v2
Checksum:i709705963BC10D28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60112 Genomic DNA Translation: CAA42709.1
PIRiC40731

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60112 Genomic DNA Translation: CAA42709.1
PIRiC40731

3D structure databases

ProteinModelPortaliQ09010
SMRiQ09010
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ09010

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012466 Dmad\Adh

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROMD
AccessioniPrimary (citable) accession number: Q09010
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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