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UniProtKB - Q08FX8 (DPV22_DPV83)
Protein
Apoptosis regulator DPV022
Gene
DPV022
Organism
Deerpox virus (strain Mule deer/United States/W-848-83/1983) (DPV)
Status
Functioni
Plays a role in the inhibition of host apoptosis by sequestering and inactivating several proapoptotic BCL-2 proteins, including BAK1 and BAX. Prevents the conformational activation of both of them.
1 PublicationGO - Biological processi
- suppression by virus of host apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Inhibition of host apoptosis by viral BCL2-like protein, Modulation of host cell apoptosis by virus |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis regulator DPV022 |
Gene namesi | Name:DPV022 |
Organismi | Deerpox virus (strain Mule deer/United States/W-848-83/1983) (DPV)Imported |
Taxonomic identifieri | 305674 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Cervidpoxvirus › |
Virus hosti | Odocoileus hemionus (Mule deer) (Cervus hemionus) [TaxID: 9872] |
Proteomesi |
|
Subcellular locationi
- Host mitochondrion 1 Publication
- Host membrane Sequence analysis; Single-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 148 – 170 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Host membrane, Host mitochondrion, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000443231 | 1 – 179 | Apoptosis regulator DPV022Add BLAST | 179 |
Interactioni
Subunit structurei
Interacts with host BAX and BAK1.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q08FX8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR036834, Bcl-2-like_sf IPR021119, Poxvirus_F1/C10 |
Pfami | View protein in Pfam PF11099, M11L, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08FX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAAIEFDEI VKKLLNIYIN DICTMGEKRL LNNYEKSILD RIYKSCEYIK
60 70 80 90 100
KNYELDFNSM YNQININDIT TSDIKSKIIE SLLIDSRPSV KLATLSFISL
110 120 130 140 150
IAEKWGEKNR TKIMEILSNE IVEKISNNGK DFIDFIDRDD DDIVDDYVLI
160 170
TNYLKITIFG AILGITAYYI CKYLLKSIF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY689436 Genomic DNA Translation: ABI99179.1 |
RefSeqi | YP_227399.1, NC_006966.1 |
Genome annotation databases
GeneIDi | 3346328 |
KEGGi | vg:3346328 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY689436 Genomic DNA Translation: ABI99179.1 |
RefSeqi | YP_227399.1, NC_006966.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UF1 | X-ray | 2.30 | A | 1-155 | [»] | |
4UF2 | X-ray | 3.00 | A | 1-155 | [»] | |
4UF3 | X-ray | 2.70 | A | 1-155 | [»] | |
SMRi | Q08FX8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 3346328 |
KEGGi | vg:3346328 |
Family and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR036834, Bcl-2-like_sf IPR021119, Poxvirus_F1/C10 |
Pfami | View protein in Pfam PF11099, M11L, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPV22_DPV83 | |
Accessioni | Q08FX8Primary (citable) accession number: Q08FX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2018 |
Last sequence update: | October 31, 2006 | |
Last modified: | September 29, 2021 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references