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Protein

Zinc finger protein 543

Gene

ZNF543

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 543
Gene namesi
Name:ZNF543
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178229.7
HGNCiHGNC:25281 ZNF543
MIMi616847 gene
neXtProtiNX_Q08ER8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914064

Polymorphism and mutation databases

BioMutaiZNF543
DMDMi313104258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868091 – 600Zinc finger protein 543Add BLAST600

Proteomic databases

EPDiQ08ER8
MaxQBiQ08ER8
PaxDbiQ08ER8
PeptideAtlasiQ08ER8
PRIDEiQ08ER8
ProteomicsDBi58695

PTM databases

iPTMnetiQ08ER8
PhosphoSitePlusiQ08ER8

Expressioni

Gene expression databases

BgeeiENSG00000178229
CleanExiHS_ZNF543

Organism-specific databases

HPAiHPA029736
HPA057665

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10226133,EBI-10172290

Protein-protein interaction databases

BioGridi125934, 2 interactors
IntActiQ08ER8, 3 interactors
STRINGi9606.ENSP00000322545

Structurei

3D structure databases

ProteinModelPortaliQ08ER8
SMRiQ08ER8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 80KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00750000117699
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ08ER8
KOiK09228
OMAiSLGCPLF
OrthoDBiEOG091G02KC
PhylomeDBiQ08ER8
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q08ER8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAQVSVT FEDVAVTFTQ EEWGQLDAAQ RTLYQEVMLE TCGLLMSLGC
60 70 80 90 100
PLFKPELIYQ LDHRQELWMA TKDLSQSSYP GDNTKPKTTE PTFSHLALPE
110 120 130 140 150
EVLLQEQLTQ GASKNSQLGQ SKDQDGPSEM QEVHLKIGIG PQRGKLLEKM
160 170 180 190 200
SSERDGLGSD DGVCTKITQK QVSTEGDLYE CDSHGPVTDA LIREEKNSYK
210 220 230 240 250
CEECGKVFKK NALLVQHERI HTQVKPYECT ECGKTFSKST HLLQHLIIHT
260 270 280 290 300
GEKPYKCMEC GKAFNRRSHL TRHQRIHSGE KPYKCSECGK AFTHRSTFVL
310 320 330 340 350
HHRSHTGEKP FVCKECGKAF RDRPGFIRHY IIHTGEKPYE CIECGKAFNR
360 370 380 390 400
RSYLTWHQQI HTGVKPFECN ECGKAFCESA DLIQHYIIHT GEKPYKCMEC
410 420 430 440 450
GKAFNRRSHL KQHQRIHTGE KPYECSECGK AFTHCSTFVL HKRTHTGEKP
460 470 480 490 500
YECKECGKAF SDRADLIRHF SIHTGEKPYE CVECGKAFNR SSHLTRHQQI
510 520 530 540 550
HTGEKPYECI QCGKAFCRSA NLIRHSIIHT GEKPYECSEC GKAFNRGSSL
560 570 580 590 600
THHQRIHTGR NPTIVTDVGR PFMTAQTSVN IQELLLGKEF LNITTEENLW
Length:600
Mass (Da):68,404
Last modified:November 30, 2010 - v3
Checksum:iEB79C2956B980DED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti470F → L in BAD18681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03217155P → A2 PublicationsCorresponds to variant dbSNP:rs6510057Ensembl.1
Natural variantiVAR_032172107Q → R2 PublicationsCorresponds to variant dbSNP:rs8100491Ensembl.1
Natural variantiVAR_032173246L → H2 PublicationsCorresponds to variant dbSNP:rs1968090Ensembl.1
Natural variantiVAR_032174287E → V1 PublicationCorresponds to variant dbSNP:rs35238720Ensembl.1
Natural variantiVAR_032175439V → D. Corresponds to variant dbSNP:rs10411486Ensembl.1
Natural variantiVAR_032176573M → V. Corresponds to variant dbSNP:rs10410649Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131547 mRNA Translation: BAD18681.1
AC005261 Genomic DNA No translation available.
BC101012 mRNA Translation: AAI01013.1
BC101013 mRNA Translation: AAI01014.1
BC101014 mRNA Translation: AAI01015.1
BC101015 mRNA Translation: AAI01016.1
AL834534 mRNA Translation: CAD39190.1
CCDSiCCDS33130.1
RefSeqiNP_998763.2, NM_213598.3
UniGeneiHs.202544

Genome annotation databases

EnsembliENST00000321545; ENSP00000322545; ENSG00000178229
GeneIDi125919
KEGGihsa:125919
UCSCiuc002qoi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN543_HUMAN
AccessioniPrimary (citable) accession number: Q08ER8
Secondary accession number(s): Q495U9
, Q495V0, Q6ZMP4, Q8NCX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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