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Protein

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Gene

WFIKKN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei138 – 139Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.954

Names & Taxonomyi

Protein namesi
Recommended name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Gene namesi
Name:WFIKKN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
ChainiPRO_000030781933 – 574WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 77By similarity
Disulfide bondi60 ↔ 81By similarity
Disulfide bondi64 ↔ 76By similarity
Disulfide bondi70 ↔ 86By similarity
Disulfide bondi132 ↔ 162By similarity
Disulfide bondi136 ↔ 155By similarity
Disulfide bondi144 ↔ 173By similarity
Disulfide bondi229 ↔ 285By similarity
Disulfide bondi326 ↔ 376By similarity
Disulfide bondi335 ↔ 359By similarity
Disulfide bondi351 ↔ 372By similarity
Disulfide bondi384 ↔ 434By similarity
Disulfide bondi393 ↔ 417By similarity
Disulfide bondi409 ↔ 430By similarity
Disulfide bondi443 ↔ 513By similarity
Disulfide bondi446 ↔ 515By similarity
Disulfide bondi457 ↔ 564By similarity
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08E66
PRIDEiQ08E66

Interactioni

Subunit structurei

Interacts with both mature and propeptide myostatin/MSTN.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000973

Structurei

3D structure databases

ProteinModelPortaliQ08E66
SMRiQ08E66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 90WAPPROSITE-ProRule annotationAdd BLAST54
Domaini124 – 175Kazal-likePROSITE-ProRule annotationAdd BLAST52
Domaini208 – 301Ig-like C2-typeAdd BLAST94
Domaini326 – 376BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini384 – 434BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini443 – 564NTRPROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Belongs to the WFIKKN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410ITYX Eukaryota
ENOG410XRTD LUCA
HOGENOMiHOG000154855
HOVERGENiHBG108676
InParanoidiQ08E66

Family and domain databases

CDDicd00109 KU, 2 hits
Gene3Di2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR020901 Prtase_inh_Kunz-CS
IPR008993 TIMP-like_OB-fold
IPR008197 WAP_dom
IPR033639 WFIKKN2
PANTHERiPTHR10083:SF87 PTHR10083:SF87, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00014 Kunitz_BPTI, 2 hits
PF01759 NTR, 1 hit
PF00095 WAP, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00131 KU, 2 hits
SM00217 WAP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF50242 SSF50242, 1 hit
SSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS51465 KAZAL_2, 1 hit
PS50189 NTR, 1 hit
PS51390 WAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q08E66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWALRGCRSG SRWGQGAALL LLLLGVPPRG LALPPLRYSH AGICPNDMNP
60 70 80 90 100
NLWVDAQSTC KRECETDQEC ETYEKCCPNV CGTKSCVAAR YMDVKGKKGP
110 120 130 140 150
VGMPKEATCD HFMCLQQGSE CDIWDGQPVC KCRDRCEKEP SFTCASDGLT
160 170 180 190 200
YYNRCYMDAE ACSKGITLAV VTCRYHFTWP NTSPSPPETT VHPTTAPPET
210 220 230 240 250
PGLDATAPAL LNHPAHQSVT VGETVSFLCD VVGRPRPEIT WEKQLEDREN
260 270 280 290 300
VVMRPNHVRG NVVVTNIAQL VIYNAQPQDA GIYTCTARNA AGVLRADFPL
310 320 330 340 350
SVVSGGQASA TAESSPNGTA LPAAECLKPP DSDDCGEEQT RWYFDAQANN
360 370 380 390 400
CLTFTFGHCH RNRNHFETYE ACMLACMSGS LAMCSLPALQ GPCKAYVPRW
410 420 430 440 450
AYNSQTGQCQ SFVYGGCEGN GNNFESREDC EESCPFPRGN QRCRACKPRQ
460 470 480 490 500
KLVTSFCRSD FVILGRISEL TEEPDSGRAL VTVDEVLKDE KMGLKFLGQE
510 520 530 540 550
PLEVTLLHMD WTCPCPNVTV GEAPLIIMGE VDGGMAVLRP DSFVGASSTR
560 570
RARKLREVMH KKTCDVLKDF PGLQ
Length:574
Mass (Da):62,994
Last modified:October 31, 2006 - v1
Checksum:i3CB4E9EE3AC08CCC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MRR8F1MRR8_BOVIN
WAP, Kazal, immunoglobulin, Kunitz ...
WFIKKN2
574Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123391 mRNA Translation: AAI23392.1
RefSeqiNP_001070353.1, NM_001076885.1
UniGeneiBt.31782

Genome annotation databases

GeneIDi531979
KEGGibta:531979

Entry informationi

Entry nameiWFKN2_BOVIN
AccessioniPrimary (citable) accession number: Q08E66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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