UniProtKB - Q08E53 (NR4A2_BOVIN)
Protein
Nuclear receptor subfamily 4 group A member 2
Gene
NR4A2
Organism
Bos taurus (Bovine)
Status
Functioni
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 260 – 335 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 263 – 283 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 299 – 318 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- glucocorticoid receptor binding Source: GO_Central
- nuclear receptor activity Source: InterPro
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
- cellular response to extracellular stimulus Source: Ensembl
- cellular response to oxidative stress Source: Ensembl
- central nervous system neuron differentiation Source: GO_Central
- central nervous system projection neuron axonogenesis Source: Ensembl
- dopamine biosynthetic process Source: Ensembl
- dopaminergic neuron differentiation Source: UniProtKB
- fat cell differentiation Source: UniProtKB
- general adaptation syndrome Source: Ensembl
- habenula development Source: Ensembl
- negative regulation of apoptotic signaling pathway Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron maturation Source: Ensembl
- neuron migration Source: Ensembl
- positive regulation of catalytic activity Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- post-embryonic development Source: Ensembl
- regulation of dopamine metabolic process Source: Ensembl
- regulation of respiratory gaseous exchange Source: Ensembl
- response to amphetamine Source: Ensembl
- response to hypoxia Source: Ensembl
- transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-BTA-383280, Nuclear Receptor transcription pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 4 group A member 2 |
Gene namesi | Name:NR4A2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:32246, NR4A2 |
Subcellular locationi
Nucleus
- nuclear speck Source: Ensembl
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326151 | 1 – 598 | Nuclear receptor subfamily 4 group A member 2Add BLAST | 598 |
Proteomic databases
PaxDbi | Q08E53 |
PRIDEi | Q08E53 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000003650, Expressed in spermatid and 17 other tissues |
Interactioni
Subunit structurei
Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3.
Interacts with PER2 (By similarity).
By similarityGO - Molecular functioni
- glucocorticoid receptor binding Source: GO_Central
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000004758 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 360 – 595 | NR LBDPROSITE-ProRule annotationAdd BLAST | 236 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 287 – 314 | Bipartite nuclear localization signal (NLS1)By similarityAdd BLAST | 28 | |
Motifi | 338 – 350 | Nuclear localization signal (NLS1)By similarityAdd BLAST | 13 | |
Motifi | 443 – 452 | nuclear export sequence (NES1)By similarity | 10 | |
Motifi | 568 – 577 | nuclear export sequence (NES2)By similarity | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 80 – 138 | Gln-richAdd BLAST | 59 | |
Compositional biasi | 127 – 233 | Pro-richAdd BLAST | 107 | |
Compositional biasi | 346 – 391 | Pro-richAdd BLAST | 46 |
Domaini
the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (By similarity).By similarity
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 263 – 283 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 299 – 318 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4217, Eukaryota |
GeneTreei | ENSGT00950000183038 |
HOGENOMi | CLU_007368_14_2_1 |
InParanoidi | Q08E53 |
OMAi | VQMHSYH |
OrthoDBi | 454476at2759 |
TreeFami | TF315430 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR003070, Nuc_orph_rcpt IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003073, NURR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01284, NUCLEARECPTR PR01287, NURRNUCRCPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08E53-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY
110 120 130 140 150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH
160 170 180 190 200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV
210 220 230 240 250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS
260 270 280 290 300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
310 320 330 340 350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK
360 370 380 390 400
SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT
410 420 430 440 450
QHIQQFYDLL TGSMEIIRGW AEKIPGFTDL PKADQDLLFE SAFLELFVLR
460 470 480 490 500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI
510 520 530 540 550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN
560 570 580 590
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC123415 mRNA Translation: AAI23416.1 |
RefSeqi | NP_001069676.1, NM_001076208.1 XP_005202534.1, XM_005202477.2 XP_005202535.1, XM_005202478.3 XP_005202536.1, XM_005202479.3 XP_010800315.1, XM_010802013.2 XP_015330896.1, XM_015475410.1 |
Genome annotation databases
Ensembli | ENSBTAT00000004758; ENSBTAP00000004758; ENSBTAG00000003650 |
GeneIDi | 540245 |
KEGGi | bta:540245 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC123415 mRNA Translation: AAI23416.1 |
RefSeqi | NP_001069676.1, NM_001076208.1 XP_005202534.1, XM_005202477.2 XP_005202535.1, XM_005202478.3 XP_005202536.1, XM_005202479.3 XP_010800315.1, XM_010802013.2 XP_015330896.1, XM_015475410.1 |
3D structure databases
BMRBi | Q08E53 |
SMRi | Q08E53 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000004758 |
Proteomic databases
PaxDbi | Q08E53 |
PRIDEi | Q08E53 |
Genome annotation databases
Ensembli | ENSBTAT00000004758; ENSBTAP00000004758; ENSBTAG00000003650 |
GeneIDi | 540245 |
KEGGi | bta:540245 |
Organism-specific databases
CTDi | 4929 |
VGNCi | VGNC:32246, NR4A2 |
Phylogenomic databases
eggNOGi | KOG4217, Eukaryota |
GeneTreei | ENSGT00950000183038 |
HOGENOMi | CLU_007368_14_2_1 |
InParanoidi | Q08E53 |
OMAi | VQMHSYH |
OrthoDBi | 454476at2759 |
TreeFami | TF315430 |
Enzyme and pathway databases
Reactomei | R-BTA-383280, Nuclear Receptor transcription pathway |
Gene expression databases
Bgeei | ENSBTAG00000003650, Expressed in spermatid and 17 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR003070, Nuc_orph_rcpt IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003073, NURR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01284, NUCLEARECPTR PR01287, NURRNUCRCPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NR4A2_BOVIN | |
Accessioni | Q08E53Primary (citable) accession number: Q08E53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 31, 2006 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families