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UniProtKB - Q08DP0 (PGM1_BOVIN)
Protein
Phosphoglucomutase-1
Gene
PGM1
Organism
Bos taurus (Bovine)
Status
Functioni
This enzyme participates in both the breakdown and synthesis of glucose.
By similarityCatalytic activityi
- EC:5.4.2.2By similarity
Cofactori
Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 19 | SubstrateBy similarity | 1 | |
Binding sitei | 23 | SubstrateBy similarity | 1 | |
Active sitei | 117 | Phosphoserine intermediateBy similarity | 1 | |
Metal bindingi | 117 | Magnesium; via phosphate groupBy similarity | 1 | |
Binding sitei | 130 | SubstrateBy similarity | 1 | |
Metal bindingi | 288 | MagnesiumBy similarity | 1 | |
Metal bindingi | 290 | MagnesiumBy similarity | 1 | |
Metal bindingi | 292 | MagnesiumBy similarity | 1 | |
Binding sitei | 357 | SubstrateBy similarity | 1 | |
Binding sitei | 389 | SubstrateBy similarity | 1 | |
Binding sitei | 515 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- phosphoglucomutase activity Source: AgBase
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- glucose metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoglucomutase-1 (EC:5.4.2.2By similarity)Short name: PGM 1 Alternative name(s): Glucose phosphomutase 1 |
Gene namesi | Name:PGM1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343708 | 1 – 562 | Phosphoglucomutase-1Add BLAST | 562 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 16 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 115 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 117 | PhosphoserineBy similarity | 1 | |
Modified residuei | 134 | PhosphoserineBy similarity | 1 | |
Modified residuei | 185 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 213 | PhosphoserineBy similarity | 1 | |
Modified residuei | 349 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 353 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 369 | PhosphoserineBy similarity | 1 | |
Modified residuei | 378 | PhosphoserineBy similarity | 1 | |
Modified residuei | 419 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 467 | Phosphothreonine; by PAK1By similarity | 1 | |
Modified residuei | 477 | PhosphoserineBy similarity | 1 | |
Modified residuei | 485 | PhosphoserineBy similarity | 1 | |
Modified residuei | 505 | PhosphoserineBy similarity | 1 | |
Modified residuei | 507 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 509 | PhosphoserineBy similarity | 1 | |
Modified residuei | 541 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PeptideAtlasi | Q08DP0 |
PRIDEi | Q08DP0 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000019011, Expressed in semitendinosus and 98 other tissues |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000025308 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 117 – 118 | Substrate bindingBy similarity | 2 | |
Regioni | 292 – 293 | Substrate bindingBy similarity | 2 | |
Regioni | 376 – 378 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the phosphohexose mutase family.Curated
Phylogenomic databases
eggNOGi | KOG0625, Eukaryota |
HOGENOMi | CLU_009330_0_1_1 |
InParanoidi | Q08DP0 |
OrthoDBi | 555015at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR005841, Alpha-D-phosphohexomutase_SF IPR045244, PGM |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit |
PRINTSi | PR00509, PGMPMM |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08DP0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKIVTVKTK AYQDQKPGTS GLRKRVKVFQ SSSNYAENFI QSIISTVEPA
60 70 80 90 100
QRQEATLVVG GDGRFYMKEA IQLIVRIAAA NGIGRLVIGQ NGILSTPAVS
110 120 130 140 150
CIIRKIKAIG GIILTASHNP GGPNGDFGIK FNISNGGPAP EAITDKIFQI
160 170 180 190 200
SKTIEEYAIC PDLHVDLGVL GKQQFDLENK FKPFTVEIVD SVEAYATMLR
210 220 230 240 250
NIFDFNALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE LGAPANSAVN
260 270 280 290 300
CVPLEDFGGH HPDPNLTYAA DLVETMKTGE HDFGAAFDGD GDRNMILGKH
310 320 330 340 350
GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVANATKI
360 370 380 390 400
ALYETPTGWK FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS
410 420 430 440 450
ILATRKQSVE DILKDHWQKY GRNFFTRYDY EEVEAEGANK MMKELEALIS
460 470 480 490 500
DRSFVGKQFP VGDKVYTVEK IDNFEYSDPV DGSISRNQGL RLLFADGSRI
510 520 530 540 550
IFRLSGTGSA GATIRLYIDS YEKDLAKIYQ DPQVMLAPLI SIALKVSQLQ
560
EKTGRTAPTV IT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC123640 mRNA Translation: AAI23641.1 |
RefSeqi | NP_001070371.1, NM_001076903.1 |
Genome annotation databases
GeneIDi | 534402 |
KEGGi | bta:534402 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC123640 mRNA Translation: AAI23641.1 |
RefSeqi | NP_001070371.1, NM_001076903.1 |
3D structure databases
SMRi | Q08DP0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000025308 |
Proteomic databases
PeptideAtlasi | Q08DP0 |
PRIDEi | Q08DP0 |
Genome annotation databases
GeneIDi | 534402 |
KEGGi | bta:534402 |
Organism-specific databases
CTDi | 5236 |
Phylogenomic databases
eggNOGi | KOG0625, Eukaryota |
HOGENOMi | CLU_009330_0_1_1 |
InParanoidi | Q08DP0 |
OrthoDBi | 555015at2759 |
Gene expression databases
Bgeei | ENSBTAG00000019011, Expressed in semitendinosus and 98 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR005841, Alpha-D-phosphohexomutase_SF IPR045244, PGM |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit |
PRINTSi | PR00509, PGMPMM |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGM1_BOVIN | |
Accessioni | Q08DP0Primary (citable) accession number: Q08DP0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 23, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families