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Protein

Mothers against decapentaplegic homolog

Gene

SMAD2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-1181150 Signaling by NODAL
R-BTA-1502540 Signaling by Activin
R-BTA-2173788 Downregulation of TGF-beta receptor signaling
R-BTA-2173789 TGF-beta receptor signaling activates SMADs
R-BTA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-BTA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-BTA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:SMAD2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:34975 SMAD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000039916 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiQ08DE0 baseline and differential

Structurei

3D structure databases

SMRiQ08DE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 146MH1InterPro annotationAdd BLAST137
Domaini244 – 437MH2InterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119091
HOGENOMiHOG000286018
HOVERGENiHBG053353

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q08DE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK
60 70 80 90 100
KLKKTGRLDE LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR
110 120 130 140 150
LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV
160 170 180 190 200
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG
210 220 230 240 250
ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY
260 270 280 290 300
ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR
310 320 330 340 350
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC
360 370 380 390 400
NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT
410 420 430
VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS
Length:437
Mass (Da):48,956
Last modified:October 31, 2006 - v1
Checksum:i0E2FF38B009D2F9E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1BE92E1BE92_BOVIN
Mothers against decapentaplegic hom...
SMAD2
467Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02056966 Genomic DNA No translation available.
BC123801 mRNA Translation: AAI23802.1
RefSeqiXP_005224229.1, XM_005224172.3
UniGeneiBt.88605

Genome annotation databases

EnsembliENSBTAT00000036594; ENSBTAP00000036451; ENSBTAG00000039916

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02056966 Genomic DNA No translation available.
BC123801 mRNA Translation: AAI23802.1
RefSeqiXP_005224229.1, XM_005224172.3
UniGeneiBt.88605

3D structure databases

SMRiQ08DE0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000036594; ENSBTAP00000036451; ENSBTAG00000039916

Organism-specific databases

CTDi4087
VGNCiVGNC:34975 SMAD2

Phylogenomic databases

GeneTreeiENSGT00760000119091
HOGENOMiHOG000286018
HOVERGENiHBG053353

Enzyme and pathway databases

ReactomeiR-BTA-1181150 Signaling by NODAL
R-BTA-1502540 Signaling by Activin
R-BTA-2173788 Downregulation of TGF-beta receptor signaling
R-BTA-2173789 TGF-beta receptor signaling activates SMADs
R-BTA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-BTA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-BTA-5689880 Ub-specific processing proteases

Gene expression databases

BgeeiENSBTAG00000039916 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiQ08DE0 baseline and differential

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ08DE0_BOVIN
AccessioniPrimary (citable) accession number: Q08DE0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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