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Protein

Copine-1

Gene

CPNE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-1483206 Glycerophospholipid biosynthesis
R-BTA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-1Curated
Alternative name(s):
Copine IBy similarity
Gene namesi
Name:CPNE1By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:27658 CPNE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004345591 – 537Copine-1Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ08DB4

Expressioni

Tissue specificityi

Expressed in liver, spleen, muscle, testis, adrenal (at protein level) (PubMed:11123945).1 Publication

Gene expression databases

BgeeiENSBTAG00000006955 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Homodimer; homodimerizes via its C2 domains. Interacts with p65/RELA (via N-terminus); this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity. Interacts (via VWFA domain) with ACTB, CCDC22, MYCBP2, PPP5C, RDX and UBE2O.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009138

Structurei

3D structure databases

ProteinModelPortaliQ08DB4
SMRiQ08DB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 98C2 1PROSITE-ProRule annotationAdd BLAST98
Domaini144 – 228C2 2PROSITE-ProRule annotationAdd BLAST85
Domaini285 – 505VWFAPROSITE-ProRule annotationAdd BLAST221

Domaini

C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner.By similarity

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
OMAiPYCQGIQ
OrthoDBiEOG091G05IT
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

Q08DB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHCVTLVQL SVSCDHLIDK DIGSKSDPLC VLLQDVGGGN WTELGRTERV
60 70 80 90 100
QNCSSPEFSK TLQLEYHFET VQKLRFGIYD IDNKTPELGD DDFLGGAECS
110 120 130 140 150
LGQIVSSRML TLPLMLKPGK PAGRGTITVS AQELKDNRVV TMEVEARNLD
160 170 180 190 200
KKDFLGKSDP FLEFFRQGDG KWHLAYRSEV IKNNLNPTWK RFSVPLQHFC
210 220 230 240 250
GGDASTPIQV RCSDYDSDGS HDLIGTFHTS LAQLQAAPAE FECIHPEKQQ
260 270 280 290 300
KKKSYKNSGT ICVKMCQVET EHSFLDYVMG GCQINFTVGV DFTGSNGDPS
310 320 330 340 350
SPDSLHYLSP TGVNEYLTAL WSVGSVVQDY DSDKLFPAFG FGAQVPPDWQ
360 370 380 390 400
VSHEFALNFN PSNPFCAGIQ GIVDAYRQAL PQVRLFGPTN FAPIINHVAR
410 420 430 440 450
FAAQAANQRN ASQYFVLLLL TDGAVTDVEA TREAVVRASY LPMSVIIVGV
460 470 480 490 500
GCADFEAMEQ LDADGGPLHT RSGEAAARDI VQFVPYRRFQ NAPREALAQT
510 520 530
VLAEVPTQLV SYFRAQGWAP FKPPPPAAKG PAQAPQA
Length:537
Mass (Da):58,923
Last modified:October 31, 2006 - v1
Checksum:iBE9B50220A6E9CB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02036525 Genomic DNA No translation available.
BC123845 mRNA Translation: AAI23846.1
RefSeqiNP_001070408.1, NM_001076940.1
UniGeneiBt.91136

Genome annotation databases

EnsembliENSBTAT00000009138; ENSBTAP00000009138; ENSBTAG00000006955
GeneIDi615677
KEGGibta:615677

Similar proteinsi

Entry informationi

Entry nameiCPNE1_BOVIN
AccessioniPrimary (citable) accession number: Q08DB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 31, 2006
Last modified: September 12, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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