Wilms tumor 1b

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• animal organ regeneration Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish."
    Sanz-Morejon A., Garcia-Redondo A.B., Reuter H., Marques I.J., Bates T., Galardi-Castilla M., Grosse A., Manig S., Langa X., Ernst A., Piragyte I., Botos M.A., Gonzalez-Rosa J.M., Ruiz-Ortega M., Briones A.M., Salaices M., Englert C., Mercader N.
    Cell Rep 28:1296-1306.e6(2019) [PubMed] [Europe PMC] [Abstract]
• fin regeneration Source: ZFINInferred from mutant phenotypeⁱ
  • "Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish."
    Sanz-Morejon A., Garcia-Redondo A.B., Reuter H., Marques I.J., Bates T., Galardi-Castilla M., Grosse A., Manig S., Langa X., Ernst A., Piragyte I., Botos M.A., Gonzalez-Rosa J.M., Ruiz-Ortega M., Briones A.M., Salaices M., Englert C., Mercader N.
    Cell Rep 28:1296-1306.e6(2019) [PubMed] [Europe PMC] [Abstract]
• glomerular visceral epithelial cell differentiation Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "osr1 is required for podocyte development downstream of wt1a."
    Tomar R., Mudumana S.P., Pathak N., Hukriede N.A., Drummond I.A.
    J Am Soc Nephrol 25:2539-2545(2014) [PubMed] [Europe PMC] [Abstract]
• macrophage chemotaxis Source: ZFINInferred from mutant phenotypeⁱ
  • "Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish."
    Sanz-Morejon A., Garcia-Redondo A.B., Reuter H., Marques I.J., Bates T., Galardi-Castilla M., Grosse A., Manig S., Langa X., Ernst A., Piragyte I., Botos M.A., Gonzalez-Rosa J.M., Ruiz-Ortega M., Briones A.M., Salaices M., Englert C., Mercader N.
    Cell Rep 28:1296-1306.e6(2019) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pronephros development Source: ZFINInferred from mutant phenotypeⁱ
  • "The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros."
    Perner B., Englert C., Bollig F.
    Dev Biol 309:87-96(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGSDVRDLSA LLPAVPTLPV GNSNSLPVGE ASQWGPMLDF HPASPYGSLP 
        60         70         80         90        100
SHSFVKQEPG WGPPDPYEDP HCGLGAFTVH FSGQLTGMHG PFADPPSSQS 
       110        120        130        140        150
RMFSNGPYLP GCMESPPAPR NQGYGTVAVD GVPSYGHTPT QHTPPFPNDT 
       160        170        180        190        200
FKHEDPMSPQ STMGEQQFSV PPPVYGCHSP PDQTLLLRNS FNSDNLYQMR 
       210        220        230        240        250
SQLECVAWNP VSSLTPSIKS SSYETEASSG APPLVYSCST QYHIHTHGLF 
       260        270        280        290        300
RGLQDVRRVP GIPSSGKSSS DSSEKRPFVC SYPGCSKRYF KLSHLQMHGR 
       310        320        330        340        350
KHTGEKPYQC DYTGCGRRFS RSDQLKRHQR RHTGVKPFQC ETCQRKFSRS 
       360        370        380        390        400
DHLKTHTRTH TGKTSEKPFT CRWPSCLKKF ARSDELVRHH SMHQRNMSKL 

QSTV                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ